BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Excited to share the first paper from my lab in @Nature ! We repurposed the widely used research tool, proximity labeling, to demonstrate its therapeutic potential in antigen amplification for immunotherapy using mouse tumor models and patient samples. https://t.co/LISBT6GzXB

As de novo pMHC binders become commodity, the role of the wild type TCR starts to evolve. Both have their place, but lately it feels like all progress was in binders. No longer. Pleased to report that the first AI-TCR against a non-viral epitope has been achieved TCR-TRANSLATE🧵

GPT-5 is here. Rolling out to everyone starting today. https://t.co/rOcZ8J2btI

I tried... 😅

Gemini CLI is our new #OpenSource AI agent that brings the power of Gemini directly into your terminal! Access Gemini 2.5 Pro with 1M token context window, 60 requests/min, and 1,000 requests/day—at no cost with a free Gemini Code Assist license → https://t.co/Fp0wdxfbEW

ChatGPT now can analyze, manipulate, and visualize molecules and chemical information via the RDKit library. Useful for scientific work across health, biology, and chemistry.

Introducing the next generation: Claude Opus 4 and Claude Sonnet 4. Claude Opus 4 is our most powerful model yet, and the world’s best coding model. Claude Sonnet 4 is a significant upgrade from its predecessor, delivering superior coding and reasoning.

Introducing AlphaEvolve: a Gemini-powered coding agent for algorithm discovery. It’s able to: 🔘 Design faster matrix multiplication algorithms 🔘 Find new solutions to open math problems 🔘 Make data centers, chip design and AI training more efficient across @Google. 🧵

Introducing OpenAI o3 and o4-mini—our smartest and most capable models to date. For the first time, our reasoning models can agentically use and combine every tool within ChatGPT, including web search, Python, image analysis, file interpretation, and image generation.

Deep Research in the Gemini App is now powered by Gemini 2.5 Pro, and our early tests show users prefer this 2:1 vs “other products” ;) https://t.co/O3Nv1uXPnK

生体の科学という雑誌で、ゲストエディターとして、「AIにより加速する生体分子デザイン」という特集を企画し、多くの先生方からご寄稿いただきました。生体分子デザインに関する最新の知見を日本語で読むことができますので、ぜひご覧ください! https://t.co/XfkM7nT1l8

Introducing Claude 3.7 Sonnet: our most intelligent model to date. It's a hybrid reasoning model, producing near-instant responses or extended, step-by-step thinking. One model, two ways to think. We’re also releasing an agentic coding tool: Claude Code.

Today we introduce an AI co-scientist system, designed to go beyond deep research tools to aid scientists in generating novel hypotheses & research strategies. Learn more, including how to join the Trusted Tester Program, at https://t.co/1eqmTTZOLr

Today we are launching our next agent capable of doing work for you independently—deep research. Give it a prompt and ChatGPT will find, analyze & synthesize hundreds of online sources to create a comprehensive report in tens of minutes vs what would take a human many hours.

check out how more details here, especially worth noting the performance of high. also, team really delivered on API pricing! https://t.co/TSPTgnzphF

We're thrilled to present ESM3 in @ScienceMagazine. ESM3 is a generative language model that reasons over the three fundamental properties of proteins: sequence, structure, and function. Today we're making ESM3 available free to researchers worldwide via the public beta of an API

Today, we shared evals for an early version of the next model in our o-model reasoning series: OpenAI o3

1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens TRACeR for MHC-I: https://t.co/AGzIC4Ooun TRACeR for MHC-II: https://t.co/U4lRENyrGu @HaotianDu4 @ljjchem @SgourakisLab @StanfordBiosci @UPennAllergyImm @CHOP_Research

Excited to share that TRACeR stories are out🙌