The Barr lab
@thebarrlab_aus
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The latest work from our lab answers a question we have been asked many times. Why do mammalian cells uptake bacteriophage? The quick answer - cells are eating the phages! See below for details on this work that was led by our PhD graduate @marion_bichet
Mammalian cells internalize bacteriophages and utilize them as a food source to enhance cellular growth and survival https://t.co/fytpOszkdI
#biorxiv_micrbio
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And to wrap up our lab's contribution to this year's @AUSSOCMIC meeting: @NandoGordillo shared his story on phage-antibiotic synergy against Acinetobacter baumannii. He's doing his best to bring this one to clinical use! #asm2021 #phage
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Second talk from our lab at this year's ASM Meeting @AUSSOCMIC. Wai Hoe @chinhoe589 shared his awesome results on phage adaptation to the mammalian gut mucosa #asm2021
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Congrats to @marion_bichet, who took the (virtual) stage on #2021ASM for her Nancy Millis Award presentation on phage-eukaryotic cell interactions.
First @AUSSOCMIC 2020 #StudentAward winner from VIC: @marion_bichet from @MonashUni presenting on: #Phage adsorption and inactivation by the Eukaryotic cell could have repercussions for the efficacy of phage therapy #2021ASM
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Wai Hoe Chin @chinhoe589 et al published a new preprint showing phage adaptation to a mammalian mucosa reveals a trans–domain evolutionary axis @thebarrlab_aus
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The lab's latest preprint is out! Beautiful work led by @chinhoe589 demonstrates phage evolution directed towards a mammalian mucosa. There's a little bit for everyone: microfluidics, evolutionary and phage biology, glycomics, and more. Go check it out!
Bacteriophage adaptation to a mammalian mucosa reveals a trans-domain evolutionary axis https://t.co/USiNHm0A31
#bioRxiv
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First PhD paper is out on @bioxrivpreprint! We showed that bacteriophages evolve and adapt directly to a mammalian mucosa, suggesting a novel trans-domain evolutionary axis! This took 3 years of coffee, microfluidics, experimental evolution & of course, phages! ⬇️Thread below⬇️🥳
Bacteriophage adaptation to a mammalian mucosa reveals a trans-domain evolutionary axis https://t.co/USiNHm0A31
#bioRxiv
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@NandoGordillo and @thebarrlab_aus found that phage therapy can resensitize superbugs to antibiotics. https://t.co/Rvs0b2Xocb
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New: Screening for Lysogen Activity in Therapeutically Relevant Bacteriophages https://t.co/bbxB6BmoK7 From @NandoGordillo and @JeremyJBarr @Monash_Science
#microbiology #protocol @NatureMicrobiol
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It was great to contribute to this issue of #cobiot x2. Our PhDs Sofia Dahlman and Laura Avellaneda wrote about using phages to shape the gut microbiota https://t.co/h2LBYVv92j and Fernando Gordillo about the importance of phage receptor identification
#review #series in @ElsevierBiotech #CoBiot on #nano #biotechnology - #Phage Therapy ...Done! Big #thanks co-#editor @MartinLoessner & #contributors for an #efficient #collaboration see all 21 #publication : https://t.co/ueaK4YVk91 + our #Editorial : https://t.co/55S1eIocUy
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.@marion_bichet and colleagues @thebarrlab_aus published a new paper showing that phage uptake by mammalian cell layers represents a potential sink that may impact phage therapy
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Last month @marion_bichet from our lab published her 1st paper of her PhD! Using real-time microscopy we demonstrate the uptake of phages by a range of human cells. We suggest cell layers of the body are an un-recognised sink for phages during therapy https://t.co/bfjosvkehj
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After many months of discussion, I am very proud to present the first paper of my thesis: "Bacteriophage uptake by mammalian cell layers represents a potential sink that may impact phage therapy" @iScience_CP @CellPressNews. https://t.co/X60aGEapXK Have a look👩🔬
/!\ NEW INSIGHTS IN PHAGE THERAPY RESEARCH /!\ After two years of research👩🔬, my first PhD paper on interactions between bacteriophages and human cells is finally out on @biorxivpreprint! 😍 #phagetherapy #phageresearch #microbiology #science THREAD ⬇️
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Congratulations to @MonashBiol's @NandoGordillo who has won the Victorian International Education Award for Student of the Year in the Research category. 👏 https://t.co/Jst9z1nKpu
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First PhD thesis from the lab submitted for examination!
Ya está, luego de 3 años y medio; 50,000 palabras y 135 páginas escritas, he enviado para examinación mi tesis de doctorado 😭🥳🤓🔬. And now, we wait...
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Standing ovation for @chinhoe589, who absolutely smashed his Final Review!
Third & final PhD milestone done & dusted (virtually)! The race begins for thesis submission & finishing papers worth 3 years of work! It's been an awesome journey with @JeremyJBarr & @thebarrlab_aus. I've learnt & grown so much & forever grateful to have had this opportunity. 🙏
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A. baumannii is the newest microbe demonstrating potential in phage therapy against the antibiotic resistance crisis. @NandoGordillo @JeremyJBarr @thebarrlab_aus @NatureMicrobiol
https://t.co/D14xq4veSL
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Fernando spoke with @AcademicTimes about our recent @NatureMicrobiol paper. Here's the story:
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.@NandoGordillo and colleagues @thebarrlab_aus show that phage-resistant A. baumannii are resensitized to antimicrobials. Phage-resistant strains had diminished fitness in vivo due to loss-of-function mutations in genes related to capsule biosynthesis
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Really pleased to share ( https://t.co/LCs1W1eMrm) our first foray into Phage experimental evolution with @DuhitaSant @JeremyJBarr and Laura Woods. Duhita has written a really nice blog post here ( https://t.co/iENjNJkrUX) but here is the thread:
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