Tinashe Chikowore
@tchikowore1
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#WellcomeTrust Fellow, Nutritionist, Gene-lifestyle interactions,#H3Africa, GWAS transethnic meta-analysis, nutrient patterns
Joined July 2015
Some 🌞Summer PGS🌞 data for you in our latest release: - BMI-stratified T2D PGS @TakaOjima @okada_yukinori
https://t.co/x2EeaOV54B - Multi-ancestry BMI PGS @tchikowore1
https://t.co/H8UVAtZ3D5 - Liver cirrhosis https://t.co/chS5sVSJGY ... & more @ https://t.co/8miwLLyrkz!
🧬Our PRS paper is out on @NatureGenet 🎯 We evaluated the impact of sample stratification👫 by trait on polygenic prediction🧬🎯 using #BMI and #diabetes ‼️ Huge thanks to all contributors and biobank participants. https://t.co/h6Cltj2vEf
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May in 3 snapshots 📸 1. Completed a lab exchange visit with Dr. @tchikowore1 @harvardmed 🧬👩🏾💻 2. Awarded a @blkwomencompbio travel grant to participate in the @bioinfoedsummit 🌏🧬 3. Co-hosted one of the largest and historic Africa focused conference in Europe🌍🎤 #phdjourney
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Happy to share env-MR-MEGA - first in our suite of environment-adjusted #GWAS methods Use summary-level data to quantify environmental and ancestral heterogeneity Amazing teamwork with @SiruRooney, @SolaOjewunmi, @ab_kamiza, Michele Ramsay, Andrew Morris, @tchikowore1, @SFatumo
Accounting for heterogeneity due to environmental sources in meta-analysis of genome-wide association studies https://t.co/YmvWbbN9lh
#biorxiv_genetic
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The last of our trio of papers on alternative classes of methods for generating PGS for multi-ancestry population @PRSdivsesity using summary statistics data is out! The whole project was possible by incredible team effort and individual leaderships by @JingningZhang35
Our paper on PROSPER, a new multi-ancestry PRS method with penalized regression is out on @NatureComms ! Check here https://t.co/d74kCIr8WB. Thanks to everyone offering help along the way!! @nilanjan10c @AndrewHaoyu @Jin_10ustc @JiananZhan @RuzhangZhao Cheng Ma and @PRSdiversity
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The upcoming @NIH Director's Seminar Series on May 17th will be presented by @genome_gov's Dr. Neil Hanchard. He will discuss his studies of human genetic variation across the African continent. Learn more about the event: https://t.co/CYj1Wj9ITa #NIH_IRP
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Today has started the strategic plan meeting for the @H3Africa v.2.0. PIs and emerging leaders in genomics in #Africa have gathered in #Mauritius and Online for a 2-days meeting aiming to design the future of genomics in Africa
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How the Navy Seal fall asleep within 2 minutes. • No pills. • No cold shower. • No bluelight blocking glasses. The 4-7-8 Method (backed by science):
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Great research at the intersection of genetics and nutrition an innovative perspective to look at malnutrition in Africa.Great work @nhnchrd
Dr. Neil Hanchard at @genome_gov hopes to improve the health of children experiencing #malnutrition by figuring out why some of them develop a life-threatening form of malnutrition called #kwashiorkor while others come down with a less immediately dangerous condition called
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Great work @nilanjan10c and team
The last of our trio of papers on alternative classes of methods for generating PGS for multi-ancestry population @PRSdivsesity using summary statistics data is out! The whole project was possible by incredible team effort and individual leaderships by @JingningZhang35
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Snippets from the past--a Sunday read: I recently revisited this gem of a paper ( https://t.co/wEIHI2qZiB) from Jonathan Cohen, Helen Hobbs and team, who first found that loss of function variants in PCSK9 reduce blood cholesterol, based on a prior work by Catherine Boileau and
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Grateful for the invite @nilanjan10c , looking forward to future collaboration in the PRS x environment interactions space
The JHU statistical genetics @jhubiostat @jhugeneticepi seminar series (online currently) is going strong. Here is a huge thank you to our amazing 2023 speakers and also welcome to our spring 2024 speakers! Kudos @ZiqiaoBiostat for organizng.
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Fresh from @NaturePortfolio great to have been part of this collaborative work, thanks to @DrRonaldMa1 @paulwfranks @NesMathioudakis @AbrarAh84 @LeeLingLim1 and team
Finally🥳📢! As part of an international consortium - the ADA/EASD #PrecisionMedicine in #diabetes Initiative (PMDI), we launched this #groundbreaking systematic review to redefine #cvd risk prediction in #T2D & explore new #biomarkers & #genetics markers https://t.co/LgxU5KUeM9
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Great work @paul_f_oreilly and team🥳🥳
Fantastic work by @clive_hoggart on development of our BridgePRS method for improving PRS prediction across ancestries - just out in Nature Genetics! (thanks to @shing_wan @Juditperala @tadesouaiaia Michael_Preuss too 👌) https://t.co/ARwjEhURyp
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Diabetes will increase the most in LMICs. 145% increase by 2030 in Africa. 67% of people in Africa are living with diabetes without knowing. Treatment coverage is less than 10% in LMICs. How can medicine be made more accessible and precise (accurate) #WorldDiabetesDay
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When I started working on #CRISPR to fight heart disease >10 years ago, I never imagined it might lead to cures for rare inborn errors of metabolism. Here’s how it’s happening! Presented/published today #ASHG23 #ASHG2023 @GeneticsSociety plenary + @AJHGNews + @HGGAdvances 🧵
How to use #CRISPR gene editing to fight heart disease, the #1 killer worldwide: A thread 10+ years in the making. This one starts in 2009 when I was a postdoc in @skathire lab @MassGeneralNews/@broadinstitute studying ❤ risk factors like cholesterol & triglycerides. (thread)
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Delighted to see this out today, coinciding with the #EASD2023 Precision Medicine in Diabetes Session A massive effort from >200 scientists to define gaps and opportunities for the clinical translation of precision diabetes medicine https://t.co/V8o78l8DFQ Key takeaways below:
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Happy to have been part of the fantastic 200 scientists who made this possible...Many thanks to @paulwfranks for the outstanding leadership and unique collaborative spirit. Indeed, tremendous and impactful science is a team sport.
A consensus report on precision diabetes medicine identifies opportunities and challenges for precision diabetes medicine. The report has been led by LUDC researcher Paul Franks @paulwfranks: https://t.co/FJHN6SFXKR
@EASDnews @AmDiabetesAssn @NatureMedicine @novonordiskfond
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@DrLizCash Hello, there is your unroll: Thread by @jenniejlin: "I recently had the privilege of attending @nih_nhlbi’s workshop for K grant awardees. It was fantastic, and in t […]" #KtoR01 #ESI
https://t.co/a9pxfry1fY Talk to you soon. 🤖
threadreaderapp.com
Thread by @jenniejlin: "I recently had the privilege of attending @nih_nhlbi’s workshop for K grant awardees. It was fantastic, and in the sp sharing tidbits I learned about how to get that R01...
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African genomics to the world, great collaboration with @AfSHGenetics
Training model to strengthen African genomics relevant data science skills globally. Thanks to all collaborators. @SeoigheCathal @GenomicsCRT @DeclanBennett5 @SickleInAfrica @AfSHGenetics @SFatumo @scottmwilliams9 @synthymama @GeneMAPOfficial @HumGen_UCT
https://t.co/NqaHFP9u8X
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