Stephanie Brumwell
@stephbrumwell
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Scientist at @CultivariumFRO. Non-model microbe enthusiast.
Joined September 2011
🚀 Breakthrough in #DiatomDNA delivery! Check out our newest preprint. Congrats to @ejlwalker @MarkPampuch Garvin Tran. Thank you, @NSERC_CRSNG and taxpayers, for sponsoring this. @SchulichMedDent @westernuBiochem
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🌟 New preprint alert ‼️ Episome delivery to diatoms just got easier. We found that spheroplasting Phaeodactylum tricornutum cells before electroporation increases transformation efficiency > 200-fold... (1/6)
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Introducing SLICER: a breakthrough method for seamless gene deletions in Deinococcus radiodurans, expanding its synthetic biology potential. #MicrobialEngineering #SyntheticBiology Details: https://t.co/G7ZU2POzi7
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Latest pub from Edgell/Gloor labs. Better sgRNA predictions in bacteria with crisprHAL. https://t.co/7Rnn7u5eo0 Huge effort (Dalton Ham @nortnlentivirus @gbgloor @tesseraqtinc). @gbgloor tweetorial ( https://t.co/ihCnk9WBtM). Thanks @CIHR_IRSC @westernuBiochem @SchulichMedDent
nature.com
Nature Communications - Current bacterial sgRNA activity models struggle with accurate predictions and generalizations. Here the authors report crisprHAL, a machine learning architecture that can...
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Congratulations to our very own @stephbrumwell for being awarded a prestigious @NSERC_CRSNG Postdoctoral Fellowship!!
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We’re thrilled to announce our support for the @iGEMAachen #iGEM2023 team! They're harnessing the bioremediation capabilities of Bacillus licheniformis and filamentous fungi to revolutionize recycling of rare earth elements from e-waste. https://t.co/GZB2oSyFDK
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New capability! A scalable framework for high-throughput identification of functional origins of replication in non-model bacteria. https://t.co/9RhGMEQ6mb (1/5)
biorxiv.org
Microbial genetic manipulation requires access to engineerable plasmids that can be programmed to perturb genes, pathways and genomes. The extensive repertoire of plasmids available for model...
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Newest manuscript from @KarasLab Congrats to @stephbrumwell and all authors. SLICER: a seamless gene deletion method for Deinococcus radiodurans | BioDesign Research @westernuBiochem @SchulichMedDent @BioDesignR
https://t.co/legK8Cq1zo
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Are you interested in taking apart and redesigning biological functions in microalgae? We are looking for a #postdoc to join our group and work on an #algae #synbio project funded by @novonordiskfond, in collaboration with @BogumilKaras and @arnspanglab.
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Latest pub from Edgell lab now online at NAR! https://t.co/lM7ZV5Iu0u Awesome work from @GregP_47 & collab with @gbgloor @EmmaAllenVercoe. Thanks to @CIHR @SchulichMedDent @westernuBiochem. Want to link dCas9 activity to a metabolic pathway? Read on!
academic.oup.com
Abstract. The ability to restrict gene expression to a relevant bacterial species in a complex microbiome is an unsolved problem. In the context of the hum
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New preprint from collaboration with @SchildPoulter using TevCas9 to create conditional Ku70 knockouts that implicate non-DNA repair functions of Ku70 as essential for cell survival. Excellent work by Rachel Kelly and Gursimran Parmar!!!
biorxiv.org
The Ku70/80 heterodimer is a key player in non-homologous end-joining DNA repair but has also been involved in other cellular functions like telomere regulation and maintenance, in which Ku’s role is...
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Who else remembers this issue of Nature? To say it was an influence on my decision to do synthetic biology is a bit of an understatement. I literally quit my day job after reading this.
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Congrats to @westernuBiochem Gabe Onea, Dr. Matt Maitland, Xu Wang, Dr. Gilles Lajoie, and Dr. Caroline Schild-Poulter for their publication in J Cell Science: https://t.co/JwzzoEA7er
journals.biologists.com
Summary: The mammalian CTLH complex forms different molecular mass complexes in the nucleus and the cytoplasm and interacts with different proteins in each compartment, and its stability in the...
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A historic moment in K-lab. The first one to graduate. @stephbrumwell Ph.D. thesis lecture "The development of Sinorhizobium meliloti and Deinococcus radiodurans as chassis for synthetic biology applications" is on July 28th @ 12:30 pm EST via Zoom and in-person in MSB 384
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📢New publication from the lab on using #microalgae for #SARS_CoV_2 pandemic diagnostics! With @SamSSlattery, @DanielJGiguere, #EmilyStuckless, @KarasLab @gbgloor and many others🧵👇 https://t.co/cKbqwPE8Be
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Are you looking for a postdoc position? And are you a bioinformatician / computational biologist with an interest in microbiology, metagenomics? Then I may have an opportunity for you @QueensUBio! Application deadline May 1st. @OpenPlastic @CSM_SCM @queensuResearch
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