Stefan Pöhlmann
@snpoehlm
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Viruses & Proteases, Head of Infection Biology Unit, Deutsches Primatenzentrum @DPZ_eu, Decoding viral entry, Tracking SARS-CoV-2 variants, Views are my own
Göttingen, Deutschland
Joined February 2021
Our starting point
Online Now and #OpenAccess in #Cell: #SARS-CoV-2 infection depends on host cell factors #ACE2 and #TMPRSS2 which can be blocked by clinically proven protease inhibitor #COVID19
https://t.co/MQ4k8Ll8WB
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Diese Woche gehts bei viroLOGISCH um das Norovirus, das ziemlich starke Durchfallerkrankungen auslösen kann, zum Beispiel auf Kreuzfahrtschiffen. ➡️ Spotify: https://t.co/1x9ypm6z8X ➡️ Apple Podcasts: https://t.co/dCQcFeMS5K ➡️ Podigee: https://t.co/XXKZfpy5Xr
virologisch.podigee.io
Virologe und Impfstoffforscher Florian Krammer wirft in viroLOGISCH wöchentlich einen Blick in die Welt der Viren – von historischen Pandemien bis zu aktuellen Entwicklungen. Ein Podcastwerkstatt...
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Concerning
⚠️Mutated H3N2 influenza heads to northern hemisphere, prepare for worst seasonal flu epidemic in decades. ✴️7 mutations appeared in a strain of H3N2 seasonal flu in June 2025. These partially evade prior immunity, and are not fully covered by the current flu jab. ✴️Linked to
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@snpoehlm Here the analysis of the four known BA.3.2 branches circulating https://t.co/lxCPYsBsF5
github.com
BA.3.2.1 Branch 1 BA.3.2.1 > A10978G > C4582T, A8755G, C12073T, N:T296I (C29160T) Query for this branch : A8755G, C12073T, C29160T Samples: 3 First 2025-08-13 Netherlands Zuid-Holland Last 20...
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Worrisome. Outbreak response thrives on genuine global collaboration. https://t.co/xK1RjwySGZ
theguardian.com
Draft template seen by the Guardian has no reference to countries receiving benefits for sharing information, such as guaranteed access to medicines developed as a result
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Tracking SARSCoV2 Lineage BA.3.2* over time Countries reporting BA.3.2*: #Australia, #SouthAfrica, #Netherlands, #USA (traveler seq), #Germany, #Mozambique, #Slovenia, #UK, #Denmark Tracker: https://t.co/NgpKv8TInX
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Breaking News: James Watson, who made one of the biggest breakthroughs in science by helping to discover the structure of DNA, died at 97.
nytimes.com
The breakthrough, with Francis H.C. Crick, made him one of the most important scientists of the 20th century. He went on to write a celebrated memoir and later to ignite an uproar with racist views.
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BA.3.2, the great pumpkin, is touring Europe. 🎃🎃
BA.3.2 has arrived in the UK. One BA.3.2.2, collected October 5, was uploaded from Scotland today. Same branch as recent BA.3.2.2 from Germany & Slovenia. It has a few errors (ins214:ASDT misread & ORF1a:E4388K artifact). Ignoring those, the 1 notable new mutation is N:N126K.
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The volume of wastewater detection of SARS-CoV-2 fell slightly in the latest week. But the share of "BA.3.2.X" detected rebounded to 25% - the highest level reported so far. 🧵
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This is a total outrage and has crippled SARS-CoV-2 variant tracking and evolutionary analysis. Updating a file and giving access to @nextstrain & @GenSpectrum does not require extensive resources. There has to be an ulterior motive here. This can't be allowed to stand.
On Oct 1, 2025, @GISAID informed us that they had ended updates to the flat file of SARS-CoV-2 genomic sequences and associated metadata that we had used to update Nextstrain analyses since Feb 2020. GISAID's stated rationale was that their "resources are limited". 1/5
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Continued surveillance and variant analysis is important, as highlighted by the emergence and spread of BA.3.2. Lack of data sharing by GISAID is bad news.
On Oct 1, 2025, @GISAID informed us that they had ended updates to the flat file of SARS-CoV-2 genomic sequences and associated metadata that we had used to update Nextstrain analyses since Feb 2020. GISAID's stated rationale was that their "resources are limited". 1/5
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A new BA.3.2 sequence. This time from the Netherlands, collected October 25. BA.3.2.1, EPI_ISL_20237246 🎃🎃🎃
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New South Wales (Australia) BA.3.2.2 now on variant graph so we can see the rise (or not) of this new variant.
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Low levels of influenza H5N1 HA and NA antibodies in the human population are boosted by seasonal H1N1 infection but not by H3N2 infection or influenza vaccination | mBio
journals.asm.org
A/H5N1 influenza A viruses continue to pose a pandemic threat to humans. Recent infection of dairy cattle and poultry with A/H5N1 in the USA has magnified that concern. We determined the level of...
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More evidence that some antibodies induced by seasonal influenza A infection or vaccination can cross-react with H5N1 - potentially offering some level of protection.
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Heute gehts bei viroLOGISCH um das MERS Coronavirus, das von Kamelen auf Menschen übertragen wird. ➡️ Spotify: https://t.co/1x9ypm6z8X ➡️ Apple Podcasts: https://t.co/dCQcFeMS5K ➡️ Podigee: https://t.co/XXKZfpy5Xr
virologisch.podigee.io
Virologe und Impfstoffforscher Florian Krammer wirft in viroLOGISCH wöchentlich einen Blick in die Welt der Viren – von historischen Pandemien bis zu aktuellen Entwicklungen. Ein Podcastwerkstatt...
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And a new BA.3.2.2 sequence from Slovenia (EPI_ISL_20236520, collected on November 2) - a first for the country. The Great Pumpkin remains active in different parts of the world...🎃
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COVID-19 remains a significant public health issue - continued surveillance is important. COVID-19 is spreading again — how serious is it and what are the symptoms?
nature.com
Nature - Limited COVID-19 surveillance data are hampering vaccination and health strategies, researchers say.
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The Great Pumpkin, BA.3.2, is back. Two new BA.3.2.2 sequences from Western Australia, collected on October 17: EPI_ISL_20236455 and EPI_ISL_20236456.
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