Simon Snoeck
@snoeck_simon
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Postdoctoral researcher, Cyril Zipfel's group (IPMB, University of Zurich), Latest story: https://t.co/0NtSqWVFgB
Joined May 2021
Disulfide bond sculpts a peptide fold that mediates phytocytokine recognition https://t.co/hMLN29nTTM
#biorxiv_plants
biorxiv.org
Precise ligand recognition by closely related leucine-rich repeat receptor kinases (LRR-RKs) is essential for plants to coordinate immunity, development, and environmental adaptation. Here, we show...
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Shedding light on the structure-function mechanisms of LRR-RPs. Our research merges #AlphaFold3, years of literature and functional validation to reveal diverse ligand-binding mechanisms and a conserved co-receptor association mechanism. https://t.co/aCb5PEMMg1
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We proudly present: Tomatoes have MIK2, too: However, it does not sense SCOOP peptides but a Fusarium elicitor. Thanks to all collaborators for the support.
biorxiv.org
Plants constantly monitor their environment to adapt to potential threats to their health and fitness. This involves cell-surface receptors that can detect conserved microbe-associated molecular...
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Are you interested in receptor kinase signalling and plant immunity? We have several positions open to join our team at @TheSainsburyLab in Norwich. #plantscience
#mpmi
#plantimmunity
#sciencejobs Please get in touch if you have questions
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Plant pattern recognition receptors: from evolutionary insight to engineering https://t.co/pyr5fL2Yys
#Review by @snoeck_simon, Oliver Johanndrees, @ThorstenNrnber1 & Cyril Zipfel Free to read here:
nature.com
Nature Reviews Genetics - Genomic and pangenomic data are yielding insights into the evolution of plant pattern recognition receptors (PRRs) and their molecular triggers. Recent advances in in...
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In @NatureRevGenet: "Plant pattern recognition receptors: from evolutionary insight to engineering" https://t.co/quEf5PJzIy ...summarizes both established and innovative approaches to () translate resulting evolutionary insights into engineering PRR recognition specificities.
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Intriguing role for N-glycosylation in LRR-RK activation: https://t.co/A37M9tdbcL and https://t.co/YhAZGKC6sD. Glad to see that cryo-EM and crystallography pinpoint the same ligand binding pockets as AF: https://t.co/qQcGfJnG6q
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Reverse engineering of the pattern recognition receptor FLS2 reveals key design principles of broader recognition spectra against ... https://t.co/MVlRyrJoYx
#biorxiv_plants
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Leveraging CZL, coevolutionary insights and AI-based structural modeling to unravel receptor–peptide ligand-binding mechanisms | PNAS
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Ten days left to apply! We will try to make a new generation of selective pesticides based on the natural defense system in plants. #ERC_research #plantscijobs #postdoc #academicjobs. Thx for RT last time, feel free to RT again or notify people that might be interested! 🙏
All I want for Christmas is a new Postdoc🎶🎄. Come join this fantastic team in Uppsala to work on protein engineering and plant-insect interaction! Please RT! #ERC_research @PlantSlu #plantscijobs More info and application via the link https://t.co/3KUr1dVWD2
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"Leveraging co-evolutionary insights and AI-based structural modeling to unravel receptor-peptide ligand-binding mechanisms". We identified 2 MIK2 binding pockets which interact with the conserved SxS SCOOP motif in a relatively quick and inexpensive way. https://t.co/QhIbNSEO9M
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One week left to apply for this postdoc position!
We are hiring a post-doctoral researcher! The 2-y research position focuses on dissecting the molecular mechanisms that cause hybrid defects. We focus on both symbiont- and nuclear-mediated hybrid dysfunction. Apply before April 3. For more info, visit
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It felt like a good time to write down some accumulated insights on RLPs. Basically, the guide I wish I had when I started studying them 3years ago.
New review preprint w @snoeck_simon @anthonygkgarcia Plant Receptor-like proteins (RLPs): Structural features enabling versatile immune recognition We analyze RLPs in light of the exciting new RXEG1 structure. Your feedback would be really appreciated! https://t.co/3BWaSmNL34
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I joined the recently established lab of @ADSteinbrenner 3 years ago, to this day exactly. I guess this is a proper way to celebrate our anniversary? ;) Thanks for the opportunity Adam, I had a blast with this one!!
Our paper with work by @snoeck_simon and @anthonygkgarcia is out today in @eLife ! We describe the evolution of herbivore peptide recognition by a plant immune receptor, and resurrect the sequence of the ancestral gene from ~28 million years ago. https://t.co/yCfN8chnAP
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Last time flying back "home" to Seattle. Glad I got the opportunity to visit both SLU and UZH. Excited to start a new chapter in 2023. Also, both places have affordable and great bakeries :)
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One to remember, so glad I got the opportunity to join and share my work after three years of talking to my computer.
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It sucks to cancel last minute for #PlantBio2022, ran out of luck, COVID finally got me although no symptoms so I should not complain. Still never made it to a plant conference in person...
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It took a while but some of my rare legumes took >6 spidermite generations timewise to just germinate... Excited to share the project which convinced me two years ago to explore the plant immunity side of plant-herbivore interactions.
Our lab’s first data manuscript is live! We describe the gain of a novel immune recognition trait across 55 my of legume evolution using genomic and functional analyses Super proud of @snoeck_simon who pushed this #EvoMPMI vision from idea to reality https://t.co/RXHxOeH2T3
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A good day after all. Seattle bucket list is getting smaller...
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