Shailab Shrestha
@shailabshrestha
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postdoc in the bernhardt lab @harvardmed studying cell envelope biogenesis | phd from @shenlabtufts studying sporulation & division in C. difficile
Boston, MA
Joined September 2015
Really happy to have this officially published! Thanks to @ShenLabTufts, @SGribaldo, and Najwa for their amazing support!. Give it a read if you’re interested in bacterial cell division, spore formation, and the evolution of PG synthases that drive them: .
nature.com
Nature Communications - The enzymes FtsW and FtsI are thought to be essential for the synthesis of septal peptidoglycan (PG) during bacterial cell division. Here, Shrestha et al. show that the...
So excited to finally share this work!!. We found an unexpected repurposing of canonical division enzymes during the evolution of endospore formation and some surprisingly unique aspects of cell division in C. difficile. Check out our preprint:
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RT @foster_lab: We are very excited to announce our latest work on how MRSA conquers antibiotics. We show that high-level resistance to met….
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RT @RamamurthiLab: The cytoplasm is not necessarily chemically uniform, says Delerue, Updegrove, & @Sylvia_Char. Surface of the developing….
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RT @ThomasMBartlett: The Bartlett Lab is open for business at the Wadsworth Center! We study pathogens with "unusual" shapes (balls & corks….
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RT @yisak_w: Officially published! I’m happy to share my first-author paper out @mbiojournal .
journals.asm.org
Bacteria and phages are in a perpetual molecular arms race, with bacteria evolving an extensive arsenal of anti-phage systems and phages evolving mechanisms to overcome these systems. This study...
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RT @BasileBeaud: Happy to share a chapter of my PhD thesis🐣! We review the diversity of the cell envelope in Terrabacteria which tell us a….
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RT @implosian: It's true, cleaned up my bench today after a memorable 6.5 years in the @baym lab! Very excited to start my own lab next mon….
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RT @MoffittLab: So excited to announce our new method for multiplexed RNA imaging in bacterial cells: bacterial-MERFISH! A huge congratulat….
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RT @yisak_w: Excited to share our recent pre-print! The Vibrio cholerae encoded Nezha anti-phage system (SIR2-HerA) restricts virulent vibr….
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RT @sciissue_077: Following up our Cell Reports paper, an avirulent C. difficle clinical isolate out-competes virulent strains in mice via….
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RT @EvolvedBiofilm: Bacillus subtilis uses the SigM signaling pathway to prioritize the use of its lipid carrier for cell wall synthesis. @….
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RT @iduggin: E. coli division machinery drives cocci development inside host cells Amazing imaging, cracking open….
biorxiv.org
We show Uropathogenic E. coli rods dividing to form and proliferate as cocci inside host cells. In these intracellular bacterial communities, the frequency of cell division outpaced the rate of cell...
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RT @SmitsLab: Identification of a new family of peptidoglycan transpeptidases reveals atypical crosslinking is essential for viability in C….
biorxiv.org
Clostridioides difficile , the leading cause of antibiotic-associated diarrhea, relies primarily on 3-3 crosslinks created by L,D-transpeptidases (LDTs) to fortify its peptidoglycan (PG) cell wall....
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RT @JohnWhitneyIIDR: My better half's second biggest accomplishment of the past six months 👶🍼.
nature.com
Nature Microbiology - Peptidoglycan biosynthesis is regulated by a feedback mechanism preventing the pathway from sequestering essential lipid carriers used to assemble and transport surface glycan...
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RT @Cyril_Anjou: It's out! My first PhD paper about the Thioredoxin systems of Clostridia!.
journals.plos.org
Author summary Cells, that are exposed to oxidative stress in their environment, must rapidly adapt and repair their proteins and thiols. The thioredoxin (Trx) system plays a crucial role in the...
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RT @mostly_microbes: Can’t believe this is out!! This is the culmination of >6yr of work to define the mode of action of the compound C10 i….
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RT @NatureComms: Diversification of division mechanisms in endospore-forming #bacteria revealed by analyses of peptidoglycan synthesis in C….
nature.com
Nature Communications - The enzymes FtsW and FtsI are thought to be essential for the synthesis of septal peptidoglycan (PG) during bacterial cell division. Here, Shrestha et al. show that the...
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RT @BostonBacteria: Happy Feb 1st!💞 .Join us burst 💥with excitement like a phage in lysis cuz 😁:. BBM 2024 is now open for registration!. I….
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RT @ItaiYanai: Our paper is out today in @Nature! Imagine getting this plot when studying single-cell data of growing bacteria! Could it be….
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RT @BostonBacteria: BrrRRrr! ❄️☃️It's cold out! Even COOLER news:.SAVE THE DATE 🗓️📢.BBM 2024 will be held June 3-4th, 2024 at the Boston U….
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