sapun p
@sapunp1
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i like working on your (and my kids') problems; Professing my love for science; what you read is what you get - nothing more and nothing less
Joined March 2020
Ever wonder how forces affect nuclear transport in cells? Check out the latest paper by Nick Scott in @UTBiomedical showing that chemotherapy transport into the nucleus depends on cell mechanics.
www.science.org
Mechanical forces felt by cancer cells tune how small-molecule chemotherapy enters their nuclei.
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Interested in how nutrition tunes metabolism and affects cancer? Check out this work by Mohini Kamra and colleagues attempting to put together the puzzle.
www.biorxiv.org
Although metastasis accounts for the vast majority of cancer-related fatalities, the triggers for the metastatic transformation of breast cancer (BC) cells remain unknown. Recent evidence suggests...
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Nice work by @madison_p1ckett and colleagues showing how ECM architecture can tune metabolic state and EMT in breast cancer.
cancerci.biomedcentral.com
The extracellular matrix (ECM) is a dynamic and complex microenvironment that modulates cell behavior and cell fate. Changes in ECM composition and architecture have been correlated with development,...
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Nice work by Christian Jennings together with the Bayer and Miller (@BGandR_lab) labs using macroscale molecular microscopy showing collagen disorganization and denaturing in a prolapse-like mouse cervix.
www.biorxiv.org
Pelvic organ prolapse (POP) is a gynecological disorder described by the descent of superior pelvic organs into or out of the vagina as a consequence of disrupted muscles and tissue. A thorough...
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Interested in how crowding affects protein structure and aging in phase separation? Check out the paper by @MateuszBrzezi18 , @jaspermichels together with the @LemkeLab.
www.biorxiv.org
Crowding agents, such as polyethylene glycol (PEG, are often used to mimic the cellular cytoplasm in protein assembly studies. Despite the perception that crowding agents have an inert nature, recent...
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A fun and nice collaboration with @StachowiakLab on lipid droplets (which are all over cells) serving as triggers phase for protein separation. Excellent work by our joint student Advika Kamatar. Looking forward to more exciting science together.
www.biorxiv.org
Membrane-associated protein phase separation plays critical roles in cell biology, driving essential cellular phenomena from immune signaling to membrane traffic. Importantly, by restricting diffus...
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Big congrats to Advika Kamatar from @UTBiomedical in our lab for being awarded an NSF Fellowship. Very well deserved for all her hard work!.
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Friends and colleagues in the @BioCondensates. Jasper Michels and I have a joint PD position to study biophysics of nucleoporins using microfluidics and microscopy experiments together with simulations. Please see the ad below!
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Congrats to Yujen Wang (not on twitter) who defended his PhD dissertation on Tuesday to such comments as "this should be the model for what we should expect from a PhD in BME". Much deserved praise and very happy for him!.
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RT @SamratLabMohali: As Program Co-Chairs, Sapun Parekh and I have put together an exciting program for the IDP-subgroup symposium on Feb 1….
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RT @UTBiomedical: Join Mia Markey as she moderates a panel with three current Texas BME grad students. Research presentations from Christia….
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Interested in how structural changes in ECM proteins control bioactivity? Check out our recent paper: Congrats to Sachin, @YuJenWang4 , Hasan, Freddy, and @ManuelKRausch1 for all the hard work!.
www.pnas.org
Fibrin is the fibrous protein network that comprises blood clots; it is uniquely capable of bearing very large tensile strains (up to 200%) due to ...
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Congrats @scheidt_tom; well deserved!!.
#EESPhaseSeparation Great privilege to be awarded a poster prize next to all the other participants. Thanks to the audience and judges for the selection. The conference was great, seeing old friends and colleagues and meeting new people (not only virtually).
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BIG Congrats (like the @buccees_c cup) to @madison_p1ckett, a second-year student @UTBiomedical, on winning the NSF #GRFP award! You are already doing great work in women's health and cancer biophysics. We are super proud of you and excited for what comes next!!!.
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This was totally rad. Thanks to @EllaSugerman from @ManuelKRausch1 lab for leading us on this adventure. Looking forward to the next visit to the @ScienceMill !.
Doing science with youngsters has been a passion of mine for a long time, but seeing these students get excited about a project that means so much to me has been uniquely rewarding. Access to hands-on science early in my childhood was essential in getting to where I am today ❤️.
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RT @EllaSugerman: Doing science with youngsters has been a passion of mine for a long time, but seeing these students get excited about a p….
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Very intersting work by @JeetainMittal and his colleagues showing liquid condensation of SOD1. Great work!
www.biorxiv.org
The toxic gain of function of Cu/Zn superoxide dismutase (SOD1) associated with the neurodegenerative disease - Amyotrophic lateral sclerosis (ALS), is believed to occur via misfolding and/or...
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