Significant increases were identified across a range of variables including positive mood, self-efficacy, agreeableness, open-mindedness, spirituality, and satisfaction with relationships. 2/2.Read the full article here: #ayahuasca #ayahuascaresearch.

A recent naturalistic longitudinal study involving Psychae researchers found that ayahuasca consumption in naïve participants is associated with improvements in mental health, relationships, personality structure, and alcohol use with most of these persisting one month later. 1/2.

The findings indicate that classic psychedelics acutely decrease activity in the DMN, while concurrently increasing global connectivity in the brain. This is a potential causal mechanism of the role psychedelics play in ameliorating depression. 2/2 .

Overactivity in the default mode network (DMN) is a hallmark of depression. A systematic review conducted by researchers at Psychae examined the modulatory impact of psychedelics such as ayahuasca on the brain regions comprising the DMN. 1/2 #ayahuasca.

The model proposes five processes as central to ayahuasca’s therapeutic benefits, including somatic effects; introspection and emotional processing; increased Self-connection; increased spiritual connection, and the gaining of insights and new perspectives

In a new article, Psychae researchers propose a novel model of psychotherapeutic and neurobiological processes associated with the consumption of ayahuasca. 1/2 #ayahuascaresearch #ayahuasca.

For patients with depression, acute depressive symptom reduction and positive physiological effects of ayahuasca ingestion appear to be modulated by an improvement in molecular biomarkers. 2/2. #ayahuascaresearch.

A recent study involving Psychae researchers Daniel Perkins and Jerome Sarris investigated the impact of modulatory biomarkers on ayahuasca’s antidepressant action. 1/2 #ayahuascaresearch.

🎄Merry Christmas from the Psychae Team!🎄. Part of the team celebrated the year’s efforts with a delicious Brazilian lunch at Bossa Nova Café. We look forward to continuing our work in 2023, but first - rest! We wish you all a wonderful Holiday Season and New Year 😊 #holidays

Broader wellbeing benefits identified included increased self-efficacy and personal spirituality, modulation of Big Five Inventory personality traits, and reductions in body disassociation and the frequency of substance use. 2/2. #ayahuascaresearch.

New study involving Psychae researchers reports ayahuasca to lead to rapid and large improvements in mental health among naive drinkers. 1/2.#ayahuascaresearch #ayahuasca

For more details regarding the study:

New study involving Psychae researchers reports ayahuasca mental health side effects to be common (55.9%) but generally transient and not severe, and for most an inherent part of ayahuasca’s potent psychotherapeutic experience: #ayahuascaresearch.

Psychae is excited to be working with the CSIRO Botanical Extracts Lab (BEL) via the @CSIRO Kick-Start Program. This work will utilise CSIRO’s research and commercialisation expertise and state-of-the-art facilities to assist Psychae in developing novel psychedelic medicines.

Psychae researchers, together with collaborators around the world, provide a comprehensive overview of the present research into how classical psychedelics modulate the Default Mode Network in this newly published paper.

Access the underlying research at #ayahuasca #ayahuascaresearch.

Psychae's @sgdruffell recently presented his research project to the @Yale Psychedelic Science Group. Simon’s work (with @IcaroScience) focused on a 6-month naturalistic study of traditionally-based use of Ayahuasca and its effects on mental health.

A great conversation featuring our very own @SimonRuffell on the @CannabisMinds podcast discussing some of the considerations for using ayahuasca in clinical settings. You can listen here: #ayahuasca #ayahuascaresearch.

We are excited to announce that Psychae Institute co-founders Jerome Sarris and Daniel Perkins will be presenting at this years Garden States 2022 event run by @EGAPolicy from 2nd-4th December!.You can learn more about the event at

Important considerations for responsible and sustainable use of ayahuasca: including risks of overharvesting and opportunities for ethical cultivation. @Chacruna_Inst #ayahuasca.