Pierre Salvy
@psalvy_
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@realLCSB, @MINES_ParisTech and @EPFL (@MSCActions) alumni, I do Computational Biology
Switzerland
Joined June 2010
What if we could... design like nature? At CAMBRIUM, we're the next-generation chemical manufacturer doing just that.
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AI + Synthetic Biology = Supermolecules. Cambrium is building the next generation chemical manufacturer, designing high-performance molecules to replace resource-intensive chemicals in polymers & personal care. This is the future of sustainable chemistry:
cambrium.bio
Cambrium is a next-gen chemical manufacturer creating high-performance, sustainable molecules for personal care, polymers, and future innovations.
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Cambrium 🔬 #TheNewWayToCloud: Designing sustainable protein biomaterials with the help of #AI.
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Did you like our last paper on #transferlearning and #gans for genome-scale kinetic models ? Well, the team carried on and they released this GEM (pun intended) today in #Biorxiv
https://t.co/SqXnaounNN
biorxiv.org
Large omics datasets are nowadays routinely generated to provide insights into cellular processes. Nevertheless, making sense of omics data and determining intracellular metabolic states remains...
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Hello everyone!! We are delighted to showcase, RENAISSANCE, a novel generative ML-based framework to efficiently parameterize kinetic models of metabolism directly from steady-state information. https://t.co/Q6XUQHD195
biorxiv.org
Large omics datasets are nowadays routinely generated to provide insights into cellular processes. Nevertheless, making sense of omics data and determining intracellular metabolic states remains...
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super excited to share that yesterday was my first day as a Visiting Professor @EPFL_en - i will be in Lausanne, Switzerland for six months! @Olympic_Capital
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Open source kinetics for all ! Such a pleasure to see this coming to light some years after the revelation we had over a beer with @realDRWeilandt !
Daniel @realDRWeilandt, Pierre @psalvy_, Maria, Georgios, Robin, Zhaleh, and Vassily @Vassily_13 just published a preprint on SkimPy, a new toolbox for kinetic modeling allowing a broad research community to easily and efficiently build kinetic models:
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Our latest work is online ( https://t.co/VYMhZ3EGZq)! In this study, we used GANs—a deep learning generative model—in metabolic engineering (for kinetic models). Sounds interesting? Thread (1/11)
biorxiv.org
Kinetic models of metabolic networks relate metabolic fluxes, metabolite concentrations, and enzyme levels through well-defined mechanistic relations rendering them an essential tool for systems...
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GANs for kinetic models in biology -- Super happy to see this project finally come to light! A paper I co-authored along with Subham (thanks for the heavy lifting!), Michael, @realDRWeilandt, Misko, and @Vassily_13
https://t.co/iGRKiiInJv
biorxiv.org
Kinetic models of metabolic networks relate metabolic fluxes, metabolite concentrations, and enzyme levels through well-defined mechanistic relations rendering them an essential tool for systems...
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Constants in big-Oh notation are typically like the calorie count in a kouign-amann: there is one; it's better for everyone not to ask about it.
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Big thanks to @pacmen_itn @DDDeCaF @EPFL who funded this research! @EPFL_CHEM_Tweet @epflSB @MSCActions
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My latest paper with @Vassily_13 on dynamic models of gene expression and metabolism (dynamic ME-models) just got published! We explore how the diauxic growth of E. coli emerges from optimal growth under biological constraints! #h2020
pnas.org
Diauxie, or the sequential consumption of carbohydrates in bacteria such as Escherichia coli, has been hypothesized to be an evolutionary strategy ...
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A novel ME model for S. cerevisiae! The latest work from @oftadehomid, @psalvy_, Maria, Maxime, Misko, and @Vassily_13 now available as a preprint: https://t.co/ftM0Tmj928
biorxiv.org
Eukaryotic organisms play an important role in industrial biotechnology, from the production of fuels and commodity chemicals to therapeutic proteins. To optimize these industrial systems, a mathem...
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Happy to share my 1st paper @realLCSB that is the 1st ME-model for a eukaryote! Wonder to know what a ME-model is? A cool tool to model cell expression & metabolism! With big thanks to @Vassily_13, @psalvy_ , Maria, Misko, Maxime. https://t.co/042Nljpx6X
biorxiv.org
Eukaryotic organisms play an important role in industrial biotechnology, from the production of fuels and commodity chemicals to therapeutic proteins. To optimize these industrial systems, a mathem...
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Happy to share this awesome research I contributed to during my PhD! A ME-model for Saccharomyces cerevisiae (a eukaryotic ME-model!), shows off Crabtree effect and its root causes in the cell proteome. https://t.co/XBOLACm7HQ
biorxiv.org
Eukaryotic organisms play an important role in industrial biotechnology, from the production of fuels and commodity chemicals to therapeutic proteins. To optimize these industrial systems, a mathem...
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Wanna know what happens inside E.coli when it has too much to eat ? My preprint on the use of dynamic ME-models to study diauxie in E. coli is out! Big thanks to @Vassily_13 @pacmen_itn @DDDeCaF for the help along the way https://t.co/o7A8VAgb8O
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Congratulations to Maria, Meriç, and Vassily for their latest paper, the first systematic reduction of a human Genome-scale model ! Analysis of human metabolism by reducing the complexity of the genome-scale models using redHUMAN https://t.co/AMiPWNczpT
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Congrats to my flatmate @RoeltjeMaas for her groundbreaking work on immune microenvironment of brain tumors! https://t.co/s2bCcDpbrG
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Avec l'avis d'Olivier Rolland @TWB_Biotech : émission @bleuoccitanie lundi 27 janvier à la minute 33:55
Toulouse : le gouvernement veut faire voler les avions au carburant vert via @bleuoccitanie
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