Paul Tsang
@paultsang518
Followers
379
Following
11K
Media
1
Statuses
1K
#chem #phy #maths Hello
earth
Joined May 2025
I really enjoyed this Nature Communications article on whether co-folding models are learning the physics of molecular interactions (spoiler: no, or not enough yet).
nature.com
Nature Communications - This study shows that deep-learning-based co-folding models often produce physically unrealistic structures and are unsusceptible in their predictions to significant binding...
0
21
129
Bioinspired Fe3O4@SiO2/L-Tryptophan/rGO Hybrid as a Photocatalyst for the Tandem Photooxidation–Condensation Synthesis of N-Heterocycles
pubs.acs.org
Developing catalysts that simultaneously drive oxidative and reductive steps under ambient conditions remains a formidable challenge in sustainable organic synthesis. Here, we unveil a four-functio...
0
2
4
Atomically Precise PbSe Nanocrystal Protected by Carboxylates | Journal of the American Chemical Society @UF @uflorida
pubs.acs.org
Pb-based semiconductor nanocrystals (NCs) are versatile building blocks for energy and information nanotechnologies. However, atomic-level control of these NCs remains an important challenge. Here we...
0
5
20
Our latest paper is out in Chemistry – An Asian Journal! Water-based aggregation triggers energy transfer—like watching an aurora in your test tube 🌌 Huge thanks to @GoWatanabe_KU & @TsuneakiSakurai. #JST #ASPIRE
https://t.co/ZF0QpPme1p
#OpenAccess
aces.onlinelibrary.wiley.com
Hydrophobic mesogenic self-assembling units induce the aggregation of a structurally distinct dibenzophenazine-cored electronic donor–acceptor–donor organic emitter in aqueous environments. This...
0
10
75
A Mismatch Minimization Strategy for Sorting in [Pd2L2]4+ Macrocycles
pubs.acs.org
Strategies for molecular sorting aim to allow the predictable formation of complex molecules or systems. Here, we report a series of ditopic bis-bidentate ligands, where each bidentate site has one...
0
2
9
Bifunctional Cationic Covalent‐Organic‐Framework for All‐Solid‐State Proton Batteries with High‐Rate and Ultra‐Stable Cyclability
onlinelibrary.wiley.com
Cationic covalent-organic-framework as a bifunctional host enables efficient proton transport and enhanced battery cyclability performance, outperforming the previously reported solid-state proton...
0
1
6
Palladium-Catalyzed Strain-Enabled [2π + 2σ] Cycloadditions of Vinyl Bicyclo[1.1.0]butanes with Methyleneindolinones
pubs.acs.org
A palladium-catalyzed [2π + 2σ] cycloaddition of vinyl bicyclo[1.1.0]butanes with methyleneindolinones has been developed. The reaction enables the construction of spirobicyclo[2.1.1]hexanes bearing...
0
0
9
Lewis Acid-Catalyzed 1,3-Dipolar Cycloaddition of Bicyclobutanes with Isatogens: Access to Tetracyclic 2-Oxa-3-azabicyclo[3.1.1]heptanes
pubs.acs.org
The ’escape from flatland’ concept has gained significant traction in modern drug discovery, emphasizing the importance of three-dimensional molecular architectures, which serve as saturated bioiso...
0
0
0
Enantioselective Synthesis of Tetrahydro-1H-1,3-methanocarbazoles by Formal (3 + 3)-Cycloaddition Using Bicyclo[1.1.0]butanes
pubs.acs.org
Asymmetric synthesis presents many challenges, with the selective formation of chiral bridged polyheterocycles being a notable example. Cycloadditions using bicyclo[1.1.0]butanes (BCB) offer a...
0
1
13
Precise Modulation of BCB Reactive Sites via Lewis/Brønsted Acid Switching for the Synthesis of Spirocycles and Bridged Frameworks
pubs.acs.org
Bicyclo[1.1.0]butanes (BCBs), which possess multiple switchable reactive sites, serve as the most direct modular scaffolds for constructing benzene ring bioisosteres. Herein, we describe the precise...
0
0
9
RNA-targeted strategies continue to reshape Drug Discovery!🧬 From oncology to rare genetic disorders, RNA is driving a new wave of therapeutic innovation. Once considered too complex to drug, it is now at the forefront of pharmaceutical and biotech research. Enamine’s RNA
0
1
7
#ChemBioChem #OnTheCover Poly(ethylene Glycol)-Based Peptidomimetics (Pegtides) of Antimicrobial Peptides (ChemBioChem 21/2025) (Marc Devocelle and co-workers) https://t.co/rfZz66BH1L • https://t.co/MPebjb6FSZ
0
1
3
On the cover of this week's issue: "Mechanistic Insights into the Borane-Mediated Conversion of 5-Carboxylcytosine to Dihydrouracil in DNA Enable an Efficient Labeling Method Using Alkoxyamines" Read it here 🔗 https://t.co/lfpDA3cSaB
0
3
9
Branching beyond bifunctional linkers: synthesis of macrocyclic and trivalent PROTACs https://t.co/EUmpvuCWsE
0
5
9
Highly Functional Allyl-Bicyclo[1.1.1]pentane Synthesis by Radical-Initiated Three-Component Stereoselective Allylation
pubs.acs.org
Rapid access to highly functional allylated BCP synthons can be achieved with good selectivity and yield through a radical, three-component reaction (3CR) regime using various combinations of radical...
0
0
17
Lewis Acid-Catalyzed Asymmetric [2σ + 2π] Cycloaddition Reactions of Bicyclo[1.1.0]butanes and Vinyl Azido/Diazo Compounds
pubs.acs.org
The [2σ + 2π] cycloaddition reaction of bicyclo[1.1.0]butanes (BCBs) and alkenes is a powerful method to construct pharmaceutically valuable bicyclo[2.1.1]hexane (BCH) frameworks. Asymmetric strate...
0
0
2
3-Oxabicyclo[3.1.1]heptanes as Isosteres of meta-Substituted Benzene Rings
pubs.acs.org
Replacement of the aromatic rings in drug candidates with isosteric rigid sp3-rich scaffolds can improve physicochemical properties, increase the chance of progressing the molecule in development,...
0
0
5
Enantioselective Dearomative [2π + 2σ] Photocycloaddition of Naphthalene Derivatives with Bicyclo[1.1.0]butanes Enabled by Gd(III) Catalysis
pubs.acs.org
The cycloaddition reactions of bicyclo[1.1.0]butanes with alkenes, imines, nitrones, or aziridines have served as an efficient platform to create conformationally restricted saturated bicyclic...
0
0
14