Nicolò Tampellini
@ntampellini_
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PhD student @MillerGroupYale 🇺🇸 B. Sc. @LabSynthesis 🇮🇹 Asymmetric catalysis with flasks and computers ⚗️💻
New Haven, CT
Joined October 2021
It's finally time to share this: my long time obsession with inherently chiral medium-sized rings now has a catalytic, enantioselective method. After a number of attempts, we developed a strategy based on choosing the maximally preorganized disconnection, which. [1/3]
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RT @KmorisakiC: Simple yet Efficient New Method for Direct Site-selective Deoxygenation of Benzylalcohol Derivatives is now out in @ChemRxi….
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RT @BaranLabReads: 🚨RADICAL RETHINK: STEREORETENTIVE CROSS COUPLING UNLOCKED🚨 Today in @ChemRxiv ( the first method….
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RT @angew_chem: Cationic, Iodine(III)-Mediated and Directed Diastereoselective Oxidation of Inert C-H Bonds in Cyclic Hydrocarbons (Nuno Ma….
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RT @MatthewHorwitz1: Join us today as @ntampellini_ from @MillerGroupYale shares his work on enantiocontrolled cyclization reactions!! Than….
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The final version of this work is now out in @J_A_C_S.
It's finally time to share this: my long time obsession with inherently chiral medium-sized rings now has a catalytic, enantioselective method. After a number of attempts, we developed a strategy based on choosing the maximally preorganized disconnection, which. [1/3]
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RT @KmorisakiC: Conceptually new asymmetric transformation—Reflexive Chirality Transfer (RCT)— appeared in @ChemRxiv (.
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RT @YaleChem: Congrats to Brandon Mercado @Fullerene , our X-ray crystallographer! He received the Lorimer Award for helping to bring Micro….
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RT @fcalcagno_: Interested in #QuantumComputing and #HPC? Join the new Master’s program at @Unibo!. Apply now:
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When you have one of the very best hammers, anything can be a nail 🤘🏻 Congratulations to the team for this awesome work!.
A final frontier of asymmetric #organocatalysis : Catalytic asymmetric fragmentation of cyclopropanes @ScienceMagazine . @ICReDDconnect @NobuyaTsuji @ravindraraut19.
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RT @ListLaboratory: A final frontier of asymmetric #organocatalysis : Catalytic asymmetric fragmentation of cyclopropanes @ScienceMagazine….
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One, two, or three? When trying to get a computational estimate of equilibrium data, which approach do you take? Why? I have the feeling there is not as much consensus on this as I thought in the past, and we have a learning opportunity :)
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Ken Wiberg is an absolute physical organic pioneer that left us many concepts and achievements - from a physical organic description of KIEs, to molecular tortures leading to [1.1.1]propellane, to applying computational tools to molecular modeling. Needless to say, so honored!🙏.
Big congrats to Nicolò, a 4th-year graduate student in the Miller Lab, for winning the Kenneth Wiberg Graduate Research Fellowship Award! Your enthusiasm and groundbreaking research motivates us all.
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Modeling serving synthesis - really beautiful work!.
Congrats to Dylan and Stephen for their method to glycosylate cotylenol and access 14-3-3 protein-client molecular glues! Donor linker design was aided by Stephen’s “autoDFT” and solved a common problem in terpenoid synthesis: contrasteric glycosylation.
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Take a look at our latest in case you don't want to resolve your modafinil analogs😉Led by @se_huth and together with Maria. Computational modeling revealed why the apparently floppy (but broadly successful!) class of Asp-derived catalysts achieve high levels of selectivity.
We are excited to share our latest study of asymmetric S-oxidation, out now in @JOC_OL! Congratulations Susannah, Nicolò, and Maria on their work elucidating the dual points of contact between the peptidic catalyst and functionalized thioether substrates.
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Find more details on ChemRXiv: Feeling very grateful to Scott and my colleagues in the @MillerGroupYale for their support on this adventure, and to our crystallographer Brandon to help us confirm the enantiodivergence!.
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What we did not expect was to find a single catalyst that proved general across two ring sizes and two different mechanistic paradigms. Also - quite the surprise - was that both DFT and X-Ray indicated that we were making the opposite enantiomer of the two ring sizes! [3/3].
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. proved effective to synthesize various strained medium-sized rings with perfect intramolecular selectivity. To the best of our knowledge, this is the first method to synthesize strained, congested seven-membered rings under mild conditions. [2/3]
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