Ndhlovu Lab
@ndhlovulab
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Lish Ndhlovu's Lab @WeillCornell focuses on transformative precision research | to eradicate HIV | and advance healthy aging l Tweets by lab members
New York, NY
Joined January 2021
Honored to receive NIH MERIT AWARD @WCM_ID in collaboration with Dr. Jonah Sacha @OHSUNews to study how stem cell transplantation can clear HIV; This research may lead to new immunotherapies for a broad cure for HIV @WCMResearch
https://t.co/ggpwT8tblQ
https://t.co/FHEx5FsrTH
news.ohsu.edu
Only a handful of people in history have been cured of the virus; three have agreed to kick off landmark research project led by OHSU.
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Delighted to share our collaborative work of a randomized clinical trial in @JIDJournal of a combined HIV reservoir-targeting drugs-NAD, auranofin, DC therapy-leading to cases of prolonged post-ART viral control #HIVCure w/ @unifesp @WCM_ID @WCMResearch
https://t.co/SA72XSeQRI
academic.oup.com
This proof-of-concept clinical trial using a combination of therapeutic interventions randomized among antiretrovirally suppressed individuals with HIV was
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Excited to share our work in @NatureComms showing how scRNA-seq in acute infection identified the relationship between HIV reservoirs and monocyte IL-1B expression. Thanks to the study participants for all their contributions. @WCM_ID @WCMresearch @MHRP
https://t.co/EvaFsEnsGD
nature.com
Nature Communications - Utilizing single-cell RNA sequencing, the authors here find that IL1B gene expression in peripheral blood monocytes associates with smaller HIV-1 reservoir size in people...
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Excited to share our review in Current Opinion in HIV and AIDS outlining the changing landscape of post-stem cell transplantation and HIV remission @OHSUNews @VGTI_OHSU @WCM_ID
https://t.co/bkyL8H5HzK
journals.lww.com
rapy (ART) were not initially known, subsequent findings from clinical cases and preclinical nonhuman primate studies have implicated mechanisms of clearance. Here, we review the six currently...
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Honored to be part of the 16th edition of "HOT TOPICS in HIV” symposium 2024. Terrific discussion on HIV vaccines, immune recovery, and remission! Thanks to Javier Martínez-Picado and @IrsiCaixa AIDS Research Institute for an amazing day!
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Sessions currently on-going https://t.co/nG0UDH7KR1
academicmedicaleducation.com
Virtual event focusing on HIV, HIV, RSV, COVID-19. 2024-09-26 to 2024-09-27
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Sharing our new commentary @NatureMicrobiol detailing how the transcriptionally active HIV reservoir contributes to immune activation/inflammation & targeting options beyond ART; in collab/w @feinsteinpc @UFScripps @WCM_ID @HOPEforHIVCure @GladstoneInst
https://t.co/zHnMEwb0O3
nature.com
Nature Microbiology - Persistence of the transcriptionally active HIV reservoir has important implications for people living with HIV, including chronic immune activation and inflammation....
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Delighted to share our new study revealing Novel Epigenetic Connections Between Retroelements and Aging in @Aging_Cell a collaboration with @TruDiagnostic @TheNixonLab @WCM_ID
https://t.co/a8CXqo0DBR
news.weill.cornell.edu
Researchers at Weill Cornell Medicine and the epigenetics company TruDiagnostic have uncovered DNA markers associated with retroelements, remnants of ancient viral genetic material, in our genes that...
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Excited to share our report in @JNeuroVirology reinforcing exhausted T cell phenotypes and pro-inflammatory monocytes associate with neurocognitive impairment and brain atrophy in people with HIV in collab with @uhmedjabsom & @umsl
https://t.co/KdfEKa2zhJ
link.springer.com
Journal of NeuroVirology - HIV-associated neurocognitive disorders (HAND) is hypothesized to be a result of myeloid cell-induced neuro-inflammation in the central nervous system that may be...
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The Next Berlin Patient: Another Man Cured of HIV After Stem Cell Transplant https://t.co/VcSCFmCior via @pozmagazine
poz.com
This man received stem cells from a donor with just one copy of a mutation that makes T cells resistant to HIV.
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Happy to share our @JVirology release on the effects of TIGIT blockade on anti-SIV T and NK cell cytotoxicity in the NHP w/ implications for combination immunotherapy; a proud collab w/ the Sacha Lab @NPRCnews @VGTI_OHSU @WCM_ID
https://t.co/sifhZfv6RS
journals.asm.org
Upregulation of the immune checkpoint receptor TIGIT is associated with HIV-mediated T cell dysfunction and correlates with HIV disease progression. Compelling evidence exists for targeting immune...
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This event will be an opportunity to learn about new biological findings from aging-related research studies and how that information can be translated into new interventions that can help older adults living with HIV. Register today! https://t.co/MWILphn0Gi
iasociety.org
All registrations for AIDS 2024 must be submitted through the online registration form. Media registration is free for accredited journalists. If you would still like to register as a group, please...
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We invite members of the HIV/aging research communities and beyond to join us July 21 for Exploring the Intersection of HIV and Aging — A Geroscience Perspective, an exciting pre-conference workshop being held in conjunction with the AIDS 2024 meeting. https://t.co/STGrlLFRfw
iasociety.org
Don’t miss out on the AIDS 2024 pre-conferences! The AIDS 2024 pre-conferences will take place on Saturday and Sunday, 20-21 July, offering the option to join in person at Messe München, Munich, or...
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🌐 Join leading experts, including IAS President @ProfSharonLewin & IAS Governing Council member @jnabukenya88, on Thursday, 30 May from 12:00-13:30 CEST for a #webinar exploring “Analytical treatment interruptions in #HIV cure research”. ☑️ Register now: https://t.co/MBB3HNcVOV
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Read our new report in @MucosalImmunol3 showing how CD89 NK cell surveillance of mucosal sites regulates cytotoxic function and the dependency on IgA/IgG class in human and NHP. In collab/w the amazing @ReevesLabNK @WCM_ID
https://t.co/3PCiZdGvho
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Proud to share our latest collab demonstrating the inflammatory response in microglia-based brain organoid models following HIV-infection perturbs bystander cells leading to neuronal dysfunction and death. With @GladstoneInst @UCSF @WCM_BMRI @WCM_ID
https://t.co/qC83Kmr2eG
academic.oup.com
Abstract. Despite the success of combination antiretroviral therapy (ART) for individuals living with HIV, mild forms of HIV-associated neurocognitive diso
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🚨Sharing our collab w the Norris Lab @vitalant & HICFA @uhmedjabsom, reporting how EVs enriched with bone and kidney markers osteocalcin, sclerostin, & nephrin associate with cognitive deficit in people with HIV on ART. @WCM_ID
https://t.co/7HppdxPzlz
frontiersin.org
Background: Although effective antiretroviral therapy (ART) has improved the life expectancy of people with HIV (PWH), the prevalence of milder forms of HIV-...
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Save the date: Join NIA on July 21 for a Pre-conference Workshop at AIDS 2024! https://t.co/u1EogWr7fM
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Thrilled to share our new report by @Preeti_Moar @KyawLinn_51 @ravi_tandon et al. in @AIDS_Journal highlighting a mammalian lectin, #Galectin9 and its link w/ inflammation in adolescents w/ perinatally acquired HIV and cognitive health. @WCM_ID @MIMHEDU
https://t.co/NNrr2Mu1aa
journals.lww.com
viral therapy (ART); however, the relationship between Gal-9 in AWH and cognition remain unexplored. Design: A cross-sectional study of two independent age-matched cohorts from India [AWH on ART...
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