Nature Metabolism
@NatMetabolism
Followers
83K
Following
2K
Media
940
Statuses
6K
Nature Metabolism publishes studies that advance our understanding of metabolic and homeostatic processes in physiology and disease.
Berlin, Germany
Joined December 2017
✨New issue✨ Check out the latest in #Metabolism research from across all disciplines. Read about #AMPK, #Cachexia, #ImmuneSignalling, #Microbiome, #NAD, #Nutrition, #TissueCrosstalk and many more topics! https://t.co/sitgPFZ96t
1
5
33
RESEARCH | Z Liu, H Chen et al. (Sichuan Univ) Elevated adipocyte-derived AFABP in obesity disrupts iron homeostasis in intestinal stem cells, which impairs PPARα signalling and blocks ISC differentiation after injury. https://t.co/4B5Bu9VqIn
nature.com
Nature Metabolism - Elevated adipocyte-derived AFABP in obesity disrupts iron homeostasis in intestinal stem cells (ISCs), which impairs PPARα signalling and blocks ISC differentiation after...
0
1
7
#Throwback REVIEW | C Dibble et al. Coenzyme A biosynthesis: mechanisms of regulation, function and disease https://t.co/GdbblpjYrU
nature.com
Nature Metabolism - This Review summarizes the fundamental aspects related to coenzyme A synthesis and its implications as a central molecule in metabolism.
1
0
7
Spatial protein gradients pattern liver metabolism
nature.com
Nature Metabolism - By modelling protein abundance as continuous spatial gradients, the study by Weiss et al., published in this issue of Nature Metabolism, reframes liver zonation as a...
0
4
11
Single-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture
nature.com
Nature Metabolism - Using the single-cell Deep Visual Proteomics technique, the authors develop a resource providing spatially resolved proteomic analysis of individual cells in human liver tissue.
0
7
26
RESEARCH | @AnneloftSdu, J Madsen, S Mandrup et al. (U of Southern Denmark) This resource highlights the remodelling of abdominal subcutaneous adipose tissue in humans undergoing lifestyle-induced weight loss followed by bariatric surgery. https://t.co/s3j9IOjo48
nature.com
Nature Metabolism - This resource highlights the compositional and transcriptional remodelling of abdominal subcutaneous adipose tissue (SAT) in humans undergoing initial lifestyle-induced weight...
0
3
19
#Throwback PERSPECTIVE | F Rao & T Xue Circadian-independent light regulation of mammalian metabolism https://t.co/tHOiR0AYI5
nature.com
Nature Metabolism - Rao and Xue discuss emerging evidence in mice and humans of circadian-independent regulation of metabolic responses by light.
0
1
9
#Throwback REVIEW | @WolfrumLab et al. Futile lipid cycling: from biochemistry to physiology https://t.co/jCD9YWyrw4
nature.com
Nature Metabolism - Sharma et al. review the regulation and biological functions of apparently ‘futile’ dynamic lipid cycle in regulating whole-body metabolic homeostasis.
1
28
78
Adipocyte NADH dehydrogenase reverses circadian and diet-induced metabolic syndrome
nature.com
Nature Metabolism - Circadian clock in adipocytes maintains metabolic health by regulating mitochondrial complex I respiration.
0
15
53
The story of amylin: from physiology to therapy
nature.com
Nature Metabolism - This Review provides an overview of the biology of amylin and highlights opportunities, as well as challenges, in the development of amylin-based drugs for the treatment of...
0
18
73
RESEARCH | R Gao, @QuanZhang11 et al. (U of Oxford) Prior hypoglycemia alters the paracrine interaction between islet cells, leading to impaired counter-regulatory glucagon secretion and increasing the risk of recurrent hypoglycemia. https://t.co/oLFs5ZdMPo
nature.com
Nature Metabolism - Prior hypoglycemia alters the paracrine interaction between islet α and δ cells, leading to impaired counter-regulatory glucagon secretion through somatostatin...
0
1
7
#Throwback REVIEW | T Nguyen & @CorveraLab Adipose tissue as a linchpin of organismal ageing https://t.co/94HH4cjxbd
nature.com
Nature Metabolism - Nguyen and Corvera review distinct changes that occur in adipose tissue during ageing, discuss potential mechanisms by which these changes impact whole-body metabolism, immunity...
0
10
24
DHODH turns cytosolic, yet cells keep growing
nature.com
Nature Metabolism - Dihydroorotate dehydrogenase (DHODH) is the only core de novo pyrimidine enzyme in the mitochondrial inner membrane, coupling nucleotide production to electron transport....
0
8
27
Ectopic expression of cytosolic DHODH uncouples de novo pyrimidine biosynthesis from mitochondrial electron transport
nature.com
Nature Metabolism - Cytosolic ScURA uncouples de novo pyrimidine synthesis from mitochondrial electron transport, and rescues pyrimidine production and cell proliferation under pharmacological or...
0
8
29
#Throwback COMMENT | J Van den Bossche et al. A call for accessible tools to unlock single-cell immunometabolism research https://t.co/TKlPbEWI3J
nature.com
Nature Metabolism - Recent technological advances permit the profiling of metabolic changes in single cells, which sheds light on how metabolism regulates immune responses. We advocate for...
0
1
9
A metabolic safety valve for reductive stress
nature.com
Nature Metabolism - The glycerol-3-phosphate shuttle links redox balance to lipid synthesis, making the relief of reductive stress costly. Pan et al. rewire this circuit with a bifunctional enzyme...
0
17
65
A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity
nature.com
Nature Metabolism - The authors present a genetically encoded tool based on a bifunctional enzyme that can regenerate NAD+ while executing an engineered glycerol shunt. The tool successfully...
1
20
75
RESEARCH | P Gu, S Zang, W Jiang, Z Huang et al. (Nanjing U) Hepatocyte-specific GPR110 mediates MASH progression by regulating hepatic oestrogen sensitivity specifically in female mice. https://t.co/Vl4SJED78D
nature.com
Nature Metabolism - Hepatocyte-specific GPR110 mediates metabolic dysfunction-associated steatohepatitis progression by regulating hepatic oestrogen sensitivity in a sex-specific manner,...
1
7
27
#Throwback REVIEW | A Yurdagul et al. Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities https://t.co/l8irGmKL0g
nature.com
Nature Metabolism - Yurdagul and colleagues offer an integrated picture of metabolic changes at the cellular and at the lesion level in atherosclerosis.
0
5
22
#Throwback METABOLIC MESSENGER | R Sinha & PM Yen Thyroid Hormones https://t.co/70axCCysfQ
nature.com
Nature Metabolism - Sinha and Yen provide a comprehensive overview of thyroid hormones and their role in development and in regulation of whole-body metabolic homeostasis
1
2
8
RESEARCH | S Christen, B Cuenoud et al. (Nestlé Health Science): This clinical study compares the efficacy of the NAD+ boosters NR, NMN and Nam in increasing circulating NAD+ levels and analyses their effects on gut microbial metabolism. https://t.co/2lbdRZ2q33
nature.com
Nature Metabolism - A comparison of the effects of different NAD+ boosters is lacking. This clinical study compares the efficacy of the NAD+ boosters NR, NMN and Nam in increasing circulating NAD+...
8
8
33