Nan Yan
@nanyanlab
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Immunologist at UT Southwestern Medical Center. My lab studies innate immunity, autoimmunity, neuroimmunology, cancer immunology.
Dallas, TX
Joined March 2019
Our latest review out in @NeuroCellPress. STING Signaling in The Brain: Molecular Threats, Signaling Activities, and Therapeutic Challenges. Lots of exciting advance of STING biology in neuroscience.
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Did not get to see the actual door until today. This is even more impressive. We should probably keep this up for historical records of the lab!
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Another Halloween, another immunology door decoration contest. This year, I had to google Taylor Swift to appreciate the genius in the posters…
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#viruses are the best cell biologists! We discover a new viral mimic of a host cell death protein required for #norovirus egress! @wang_guoxun @HancksLab @OrchardLab_Rob @utswimmuno @utswnews 🧵 1/ https://t.co/Lh6j1d2Oqc
nature.com
Nature - The murine norovirus NTPase NS3 induces mitochondrial disruption, resulting in cell death, which is required for viral egress.
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A lot of neurological diseases are associated with abnormal STING trafficking. Including #Parkinsons, #ALS, #FTD, #NPC, and more. Check out the Tables and Figures in the review.
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It’s amazing how many cofactors are involved in moving STING along the vesicular trafficking pathway. All 3 types of coated vesicles, COPI, COPII and Clathrin, are involved. Blocking them could either promote or inhibit STING signaling.
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New review article on STING trafficking to start 2023! We discuss how STING trafficking influences signaling, propose a model of tonic STING signaling, and discuss an emerging link between dysregulated STING trafficking and neurodegenerative disease. https://t.co/5z4h6HB0u9
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🚨Texas Immunologists! Please consider attending the Texas Symposium on Critical Topics in Immunology February 17-18 at TAMU. Highlights include a great lineup of national and local speakers, mentoring/networking lunches, and a poster session for trainees. https://t.co/Es1qZTnM2i
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Here is an artistic rendering of the model. We call: Hidden (immune) powers of the vesicle trafficking pathway.
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Key findings: - STING continuously moves from ER to Lysosomes at the resting-state. - Interruption of Golgi-to-Lysosome trafficking activates STING and tonic IFN signaling. - Implication on neurodeg diseases with endolysosomal defects. - New way to activate STING for cancer.
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New paper from the lab on STING trafficking and signaling biology. Congratulations to graduate student Xintao Tu (now at Merck)! @UTSWNews @utswimmuno
https://t.co/2wUkwMIAA2
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Halloween Door Decoration 2022! IMMUNOPOLY edition. The CHANCE and COMMUNITY CHEST cards are hilarious. My favorites are: ‘Key lab materials are back-ordered. STOP 1 round’, ‘Paper published open access. PAY $6000 fee’. Congrats to students Cong and Zhen who designed this!
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Congratulations to our Immunology Department Chair @LHooperLab for election to National Academy of Medicine! @theNAMedicine @UTSWNews @utswimmuno 🎉🎊🍾🥂
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We are looking for Postdoctoral Fellows and Research Associates in the Yan lab at Department of Immunology, UT Southwestern Medical Center. If you are interested in innate immunity, inborn error rare disease mechanism, neuroimmunology, please apply! #RareDisease #Immunology
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Thanks for highlighting our study! @NatRevImmunol
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