Moriarity & Webber Lab
@mw_umn_labs
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Base Editing | Stem Cell Biology | Gene Therapy | Cell Therapy | Cancer Immunotherapy | @beau_webber & twitterless Branden | tweets by grad students
Minneapolis, MN
Joined March 2021
Excited for #Deaminet! Registration is open join leaders in RNA editing & deamination research,Secure your spot before we hit capacity: https://t.co/ciGX3U0qZ1 ( https://t.co/YSIqigg5JS). Top sponsors, amazing sessions, & a collaborative community. Don’t miss out bring your lab!
labs.uthscsa.edu
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Excited for #Deaminet! Registration is open join leaders in RNA editing & deamination research,Secure your spot before we hit capacity: https://t.co/ciGX3U0qZ1 ( https://t.co/YSIqigg5JS). Top sponsors, amazing sessions, & a collaborative community. Don’t miss out bring your lab!
labs.uthscsa.edu
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New paper dropped! Led by @ThosVarley and Pai Vaibhav, we show that flows of information within a #xenobot resemble flows of information observed in adult human brains. Thomas provides caveats and context below. w/ @drmichaellevin, Caitlin Grasso, & Jeantine Lunshof.
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Another crazy breakthrough Scientists at Monash University have created a tiny fluid based chip that behaves like neural pathways of the brain, potentially opening the door to a new generation of computers. A coin sized chip made from a metal organic framework (MOF) can channel
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Huge thanks to the Minneapolis City Soccer Club! This year’s Gene Party raised $7,500 for the UMN Center for Genome Engineering! 🧬⚽️ @mplscitysc @umncge
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Targets of protective immunity and opportunities in hepatitis C virus vaccine development
nature.com
Nature Reviews Immunology - Despite the advances in hepatitis C treatment, a prophylactic vaccine is still not available and will be needed to control and eliminate hepatitis C virus (HCV)...
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This protein could be used to sense magnetic fields and temperatures inside individual cells. https://t.co/NR2QZMyJ1r
sciencenews.org
Researchers could use quantum effects to develop new types of medical imaging inside cells themselves.
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Now online! IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity
cell.com
IL-25 treatment induces persistent adaptation of the small intestine, which is maintained by ILC2s with functional and epigenetic qualities of immune memory. Effector-memory ILC2s arise in multiple...
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Following injury from a heart attack, immune cells called neutrophils release a peptide that punctures stressed heart cells and destabilizes their electrical activity. This triggers life-threatening arrhythmias. These findings in Science offer a novel explanation—and potential
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SCGE researchers demonstrate proof-of-concept of multiorgan mutation correction in cystic fibrosis using peptide nucleic acids encapsulated in polymeric nanoparticles and delivered systemically in utero. #PublicationFriday
https://t.co/c4JO8jRAxU
pnas.org
In utero gene editing has the potential to modify disease-causing genes in multiple developing tissues before birth, possibly allowing for normal o...
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Even as we approach 3 years without Chris, we often find ourselves reminiscing on memories with him. His family asked us to share an invitation to his upcoming memorial on October 12. If you would like to attend, please RSVP using this form: https://t.co/r1Ob9VPpv4
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Longevity gene therapy paper retracted. First retraction for George Church. Situation involved BioViva, co. headed by unlikely longevity figure Liz Parrish. Best quote from co-author: “I have retired and I am in Greenland. I do not have to talk to you.” https://t.co/aAizHc5X6G
retractionwatch.com
George Church A paper coauthored by geneticist George Church has been retracted following an internal review at a university where several coauthors are based. The article appeared in the Proceedin…
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Huge 3D Printing Breakthrough! Caltech is printing metal atom by atom. A hydrogel scaffold soaked in metal salts becomes the blueprint, the gel burns away, and oxygen is stripped in a hydrogen-rich chamber, leaving alloys crafted with surgical precision. They can change metal
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Un-TIL It’s Cured: The MN TIL Alliance is set for Friday, July 25th from 4:00–7:00 PM. @2231 6th Street SE Minneapolis, MN 55455 Building Abbreviation: CCRB Building ID: 01-153
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Now, we’re building a Minnesota based TIL alliance—Un-TIL It’s Cured—uniting researchers, nonprofits, and industry leaders to accelerate TIL therapy together. We’re excited to share that the kick-off event for Un-TIL It’s Cured: The MN TIL Alliance
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Minnesota based TIL alliance—Un-TIL It’s Cured : We are working to advance Tumor Infiltrating Lymphocyte (TIL) therapy, a powerful approach showing real promise, for advanced solid tumor cancers. https://t.co/jHIGy3oXK1
today.com
Emma Dimery joined the clinical trial after running out of treatment options. For two years, she's been cancer free.
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SCGE researchers develop a base editing approach exploiting a naturally occurring CD33 single nucleotide polymorphism leading to removal of full-length CD33 surface expression on edited cells. #PublicationFriday
https://t.co/UkMvuu5BYT
nature.com
Nature Communications - Here, the authors show that base editing of CD33 and gamma globin genes in HSPCs results in the long-term engraftment of dual edited cells along with HbF reactivation and GO...
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📰New paper from the lab! Using our transgenic TCR model we reveal that T cell beta-selection can be bypassed via a γδ TCR alternative path that allows T cell maturation to continue. This path appears highly dependent on IL-7 signaling. Read here! https://t.co/uZVFAO6uJY
academic.oup.com
Abstract. Thymocyte maturation is a tightly controlled and sequential process of T cell receptor (TCR) gene rearrangement that generates a broad repertoire
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Stronger legs are associated with larger brain volume & slower cognitive decline. 🧵1/7
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