Matt Nelson
@mnelsonxy
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Husband. Father. Triathlete. Scientist devoted to improving drug discovery and development through human genetics.
Wilton, CT
Joined December 2009
Published today, our reasons for optimism that success rates in drug discovery can be improved by picking the right targets using human genetics: https://t.co/kgh9q05buE I break the key findings down panel by panel in this thread: https://t.co/5h6q4EYYrw
Is having even more gene-disease associations still useful for picking drug targets? For which types of programs does it matter? Has pharma shifted focus towards genetically validated targets? New paper by me, @mnelsonxy, @DongCoco90417, & @jivecast
https://t.co/KNUV1MNq3H👇
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Lightning summary: - Drug programs supported by human genetics are more successful, almost regardless of the nature of the genetic evidence - Increase in success rate may be especially large for disease-modifying therapies - Genetics still underutilized in picking targets
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Today @mnelsonxy and I have posted to @medrxivpreprint an analysis showing that labeled side effects of approved drugs are enriched for genetic evidence https://t.co/GJ8AbFWtdK
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#DYK #genomics is helping us predict disease? Can our genes help find new #medicines too? We’re hosting a #hackathon w/ @targetvalidate @biodataworld to see what the data will show 🔍
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Now I can tweet from my Blackberry app. Of course, nobody gives a rip. If you tweet and nobody reads it, do you make a sound?
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