Yogesh M. Gangarde
@m_gangarde
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Postdoctoral researcher at OSU, Oregon, USA. Student of chemical biology, Genetic code expansion, and synthetic organic chemistry.
Maharashtra, India
Joined October 2020
#ChemAsianJ Harnessing RNA-Protein Interactions for Therapeutic Interventions (Ishu Saraogi and co-workers) @SaraogiIshu @iiserbhopal @chm_iiserb •
aces.onlinelibrary.wiley.com
RNA binding proteins (RBPs) interact with RNA via RNA binding domains (RBDs) and regulate fundamental cellular processes. Exploiting these interactions offers significant opportunities for drug...
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We are happy to inform that, Dr. Ishu Saraogi, Associate Professor, Department of Chemistry, IISER Bhopal has been awarded the Thieme Chemistry Journals Award 2024. Please join us in congratulating Dr. Saraogi for this recognition and wishing her many more laurels in the future.
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Excited to share our recent efforts in developing tRNA-based therapeutics. This was a rather large effort…..“Optimization of Anticodon Edited Transfer RNAs (ACE-tRNAs) Function in Translation for Suppression of Nonsense Mutations”
biorxiv.org
Nonsense suppressor tRNAs or AntiCodon-Edited tRNAs (ACE-tRNAs) have long been envisioned as a therapeutic approach to overcome genetic diseases resulting from the introduction of premature stop...
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Peptidyl-tRNA hydrolase is the nascent chain release factor in bacterial ribosome-associated quality control: Molecular Cell
cell.com
Svetlov et al. show that, following ribosome splitting, peptidyl-tRNA that remains stuck inside the large ribosomal subunit is released by peptidyl-tRNA hydrolase (Pth). This release requires the...
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