Lars Longwitz
@Longlarf
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PhD @likat_rostock, Postdoc @Maes_Group & @RoelfesGroup Now (substitute) professor in organic chemistry @unihh
Hamburg, Germany
Joined May 2017
For updates of the lab and a small sneak peak of "Longwitz Lab" science, you can now visit the group's website, all about Evolvable Catalysis.
www.chemie.uni-hamburg.de
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After my first week at @unihh, I am even more excited than before. Lots of interesting chemistry, motivated students, welcoming colleagues and a super-team of supporters, especially in the IT. I can't wait to give my first lectures in "Hörsaal A" next week. 🦥.
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A good start to the new year: I was awarded the Postdoc Prize 2024 of the Faculty of Science and Engineering in Groningen! Very happy to receive this award to recognize my achievements in the @RoelfesGroup ! Now, I am looking for a new adventure!
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RT @RoelfesGroup: Fantastic start of 2025 for the group. Our own @Longlarf won the @univgroningen FSE Postdoc prize for 2024. This prize ce….
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Another boron enzyme from my postdoc, this time with a new protein scaffold. Getting closer and closer to natural enzymes design with our own catalytic dyad! Thanks to all who contributed!.
We are delighted to introduce our new Boron Designer Enzyme for the kinetic resolution of α-hydroxythioesters. For this activity, the noncanonical amino acid and a natural lysine residue have to work together to form a Hybrid Catalytic Dyad!
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What would a reaction like this be called? Not really a deracemization, not really a desymmetrization, a double kinetic resolution?
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RT @RoelfesGroup: Lars @Longlarf presented his work on Boron catalysis in designer enzymes at #biocat2024 in Hamburg. Check out his poster….
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Cool paper using LmrR Boron Enzymes!.
Design and Evolution of an Artificial Friedel–Crafts Alkylation Enzyme Featuring an Organoboronic Acid Residue | Journal of the American Chemical Society @TotalSyntheses #FriedelCrafts #Alkylation #Biocatalysis #Organoboronic
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RT @J_A_C_S: Design and Evolution of an Artificial Friedel–Crafts Alkylation Enzyme Featuring an Organoboronic Acid Residue | Journal of th….
pubs.acs.org
Creating artificial enzymes by the genetic incorporation of noncanonical amino acids with catalytic side chains would expand the enzyme chemistries that have not been discovered in nature. Here, we...
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Hanging out at my poster P4-2 at #biocat2024. Come talk to me about not boring, but boron enzymes.
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Presenting my results from the @RoelfesGroup at #nordbioII in Stockholm. A great event so far, lots of interesting biocatalysis.
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RT @effe_zeta: This month, an exciting paper has been published in @Nature from @RoelfesGroup, reporting the design of a boronic acid-integ….
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RT @esrfsynchrotron: A newly designed enzyme containing boron shows promising catalytic properties currently not found in nature. It could….
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RT @Boron_Chemistry: Boron catalysis in a designer enzyme (@Nature): (@RoelfesGroup, @LongLarf, @reubenlg). https:/….
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RT @Nature: Nature research paper: Boron catalysis in a designer enzyme
www.nature.com
Nature - A completely genetically encoded boronic-acid-containing designer enzyme was created and characterized using X-ray crystallography, high-resolution mass spectrometry and 11B NMR...
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Turning Boron proteins into functional enzymes was the most challenging but rewarding project of my career (so far)! I learned so much during this project and want to thank all collaborators and members of the Roelfes and Mayer group @narf42 for their support!.
We are excited to present a new element as the star of biocatalysis - BORON!.In this story, a boronic acid-based amino acid unlocks an abiological activation mode in our artificial enzymes, whose improved variants gave phenomenal selectivity in a new-to-nature kinetic resolution.
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RT @RoelfesGroup: It's time to mark the end of an era in our old labs with a new group photo!.As we say goodbye to our old building at #Nij….
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RT @narf42: 🚨🚨🚨 We are hiring! We are looking for 2⃣ PhD students who want to join us @StratinghInst for awesome research in the field of c….
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