Leo Speidel
@leo_speidel
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Statistical and Population Genetics | RIKEN, iTHEMS (Japan) | 🇯🇵🇩🇪🇬🇧 |
Tokyo, Japan
Joined January 2015
Happy New Year! Our Twigstats paper is now out!
nature.com
Nature - Twigstats, a method for ancestry reconstruction, provides high-resolution genetic histories and movement patterns of people living in Europe during the first millennium ce.
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New ad for an independent postdoc in mathematics/statistics/machine learning for Biology in my institute at RIKEN (not my lab), ranging from 3 to 7 years. Our institute is entirely English-run, and a good mix of expertise on maths/physics/stats/bio! https://t.co/CAss6QvGLr
riken.jp
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🚨New preprint out! 🧬Short reads can now decode centromeres. 🌍We reveal population-scale centromere haplogroups and their links to disease. https://t.co/81oLxkNoUj (1/n)
biorxiv.org
Centromeres are among the most diverse and dynamically evolving regions of the human genome and are commonly affected in various human cancers. However, organized into highly repetitive α-satellite...
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インタビュー【MEET a rising star at RIKEN】 理研で活躍する若手研究者が理研の魅力や研究環境、日々の暮らしを語ります。第1回はシュパイデル玲雄（@leo_speidel）理研ECLユニットリーダー。数学・統計学を用いてヒトの進化・歴史を追求しています。 📹 https://t.co/SjamhoFPGt
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Postdoc position in my group in Tokyo! Please get in touch if you are interested. And happy to discuss projects - ranging from developing new methods to analysis of new genomes that we are now sequencing in the lab. https://t.co/RurkIGI2TC Lab page:
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Our new paper is out in @ScienceMagazine! By exploring the rich genetic diversity of Brazil, we show how fine-scale genomic analyses reveal that this diversity, rooted in Indigenous ancestry and centuries of complex demographic history, plays a key role in population health.
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I have a 2 year postdoc position available on our 'COREX: from correlations to explanations' grant: https://t.co/9sYVaCJSDo. See: https://t.co/lmFme3GtJd... working at the intersection of archaeology, computational modelling and stats. Starts Nov 2025.
ucl.ac.uk
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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これまで統合生物考古学セミナーや進化学会夏の学校などで扱ってきました内容を中心に，「ゲノム多様性解析」として森北出版から出版予定です．多くの方のご協力を仰ぎました． 類似の日本語教科書はないと思いますので，ご興味のある方はぜひ手にお取りください． https://t.co/f12QzwYVIf
morikita.co.jp
森北出版で発行している書籍「ゲノム多様性解析」の詳細ページです。
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Applications are now open for the #EMBOpopgen course - deadline 24th Feb! All information here: https://t.co/2gOP1SQNf5
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Our papers, out today in @nature, show how ancient DNA from the Eneolithic and Bronze Age steppe points to a North Pontic origin of the Indo-European language family and a Caucasus-Lower Volga (CLV) origin of Indo-Anatolian (inclusive of the now extinct Anatolian languages). 1/
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Congratulations Sile! And really fascinating & clean result seeing conservation of effect sizes across human groups using local ancestry in admixed people!
Excited to see my project at @UniofOxford finally published at @NatureGenet ! Huge thanks to my co-authors @simon_r_myers @danjlawson @marchini @g_hellenthal @linoafferreira @ShiSinan , and the reviewers/editors. Read the publication here: https://t.co/BhiT6uR6AI 🚀🎉
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Excited to see my project at @UniofOxford finally published at @NatureGenet ! Huge thanks to my co-authors @simon_r_myers @danjlawson @marchini @g_hellenthal @linoafferreira @ShiSinan , and the reviewers/editors. Read the publication here: https://t.co/BhiT6uR6AI 🚀🎉
nature.com
Nature Genetics - This study introduces the concept of Ancestry Components and shows that they can offer improved population stratification correction for geographically correlated traits. By using...
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Excited to share our preprint "A putative ecocline in Klebsiella pneumoniae" and super-interested to get your feedback. Really want to use the hive mind to get to the bottom of this phenomenon ASAP.
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Modern GWAS can identify 1000s of hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm excited to present our new work combining associations + Perturb-seq to build interpretable causal graphs! A🧵
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One week to the abstract submission deadline for SMBE 2025, Beijing 20-24 July! https://t.co/g1MhJqWSSy
@ana_ignatieva and I are organising a symposium on popgen through time: using ARGs, aDNA, or otherwise to understand the evolutionary processes that shape genomes through time.
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A genealogy-based approach for revealing ancestry-specific structures in admixed populations https://t.co/37NyO1Flve
#biorxiv_genetic
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Delighted to see our new paper out in Nature https://t.co/4dOTqJT2vS
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Our new paper is out! Congrats to the whole team, especially the staff and students @bournemouthuni who have been excavating this incredible site for 15 years (with much more left to uncover!) Widespread matrilocality in Iron Age Britain - Up Na Mná :) https://t.co/OdQyQYR6nV
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(1/6) Excited to share our manuscript describing Quickdraws, a novel algorithm and software to perform GWAS that increases association power while keeping computational costs low. More details below (thread). Link to article:
nature.com
Nature Genetics - Quickdraws is a mixed-model association tool with a noninfinitesimal prior for analyzing binary and quantitative traits, using a scalable variational inference that allows...
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