KerosuoLab
@KerosuoLab
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Developmental biology lab focused on neural crest development and disease. Tweets are our own. #NeuralCrest #ChickEmbryology #organoids
Joined September 2018
Our paper on how the whole #ectoderm maintains #pluripotency and enables the exceptional #NeuralCrest stem cell potential is published! Very proud of the whole team and a shout out for the first author @pajanoja for pure excellence😘! #devbio 🐣
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Tune in on Thursday!.
Enjoyed yesterday’s ‘From preprint to publication’ webinar featuring @RogerPocockMelb. Next week, @EstermannMartin will talk to Laura Kerosuo about her work on neural crest stem cell potential - work that was preLighted by Andrew Montequin. Register here:
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RT @adameykolab: Adameyko lab is hiring! We search for an experimentalist postdoc (preferably with a bit of computational skills) to work w….
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Our paper that challenges #gastrulation by showing #pluripotency signature in the entire #ectoderm as bases for #neuralcrest stem cell potential formation was chosen to the editor's highlights at @NatureComms / stem cells. Very proud of the whole team!.
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New information on pigment formation! #neuralcrest.
The latest results from our ongoing collaboration with @MasahikoHibi and @HisashiHashimoto.A gene regulatory network combining Pax3/7, Sox10 and Mitf generates diverse pigment cell types in medaka and zebrafish
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RT @werner_achim: New preprint identifying shared and distinct mechanisms of inactivation of the #ubiquitin E1 enzyme #UBA1 across differen….
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A nice summary of our new paper @NatureComms explaining a paradigm shifting finding about #gastrulation: the #ectoderm does not lose the pluripotency signature, which enables maintenance of the exceptionally high stemness of #neuralcrest @NIDCR
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Hieno tiivistelmä uudesta työstämme @NatureComms: osoitamne miten hermostopiena saavuttaa poikkeuksellisen kantasolumaisuutensa. Alkio ei menetäkään monikykyisyyttään gastrulaatiossa, mikä mahdollistaa kasvojen, lisämunuisen ja monien kehon kudosten kehityksen. Kiitos @pajanoja.
Tutkijat ovat saaneet uutta tietoa alkionkehityksen tärkeimmästä varhaisvaiheesta. Tutkimustulokset auttavat ymmärtämään monia synnynnäisiä kehityshäiriöitä paremmin. @KerosuoLab @helsinkiuni @NIH .
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Introducing the lab! Thank you @the_Node! Check out who we are and how we study #neuralcrest. Let me know if you’re interested in joining us @NIDCR @NIH Bethesda campus in Washington DC.
Lab meeting with the Kerosuo Lab . Meet the members of the @KerosuoLab @NIDCR. The lab studies early neural crest development and the pathology behind neural crest derived diseases:. ➡
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Interesting!! Check out the new paper from the Theneveau lab!.
#EMT is an early event in cell dissemination from epithelial tissues. @EricTheveneau &co show that in frog embryos the #metalloproteinase MMP28 is produced by placodes & acts inside the nucleus of neighboring neural crest cells to trigger EMT #PLOSBiology
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Check out our work @NatureComms! A result of an enjoyable and fruitful multidisciplinary @NIDCR collaboration with the Werner lab @werner_achim revealing how a @ubiquitin based post- translational mechanism orchestrates early cranial ectodermal patterning. 🐣#devbio #NeuralCrest.
When #ubiquitin meets🐣 @NIDCR: check out our inspiring collaboration with @kerosuoLab, revealing how early brain, craniofacial and skin development are coordinated by a monoubiquitylation-based switch. Now out @NatureComms at Thank you to the team!
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Very proud of my student @jennhsin at her first conference and also happy for seeing her fully enjoy it!! #anr2023. We received a lot to digest and got to enjoy Amsterdam #neuroblastoma #neuralcrest.
Learned so much at #anr2023 last week, it was really an amazing conference. Also got to present a poster at my first big scientific conference- got great feedback/ideas so thank you to everyone who stopped by!
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Introducing the world of research to the next generation on #BringYourKidsToWorkDay was a success! Who has a faster heartbeat, you or the #ChickEmbryo? @NIDCR
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Check out the new preLights featuring Ceren’s @pajanoja work! Thank you Andrew @RefriedEctoderm for highlighting our research 🙏🙏 #NeuralCrest #pluripotency.
When does the embryo finally lose #pluripotency?. @pajanoja and team at the @KerosuoLab identify a transcriptional signature of pluripotency that is maintained throughout #neurulation in the #ectoderm. #preLight by Andrew Montequin @RefriedEctoderm. 👉
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RT @ChrisToseland: I don’t usually post personal news but Clinicians have told us to pull every lever. Our daughter has with #dipg Brain c….
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Pluripotency genes are co-expressed in the developing neural crest at all axial levels independent of the future neural crest lineage they will commit to. We also show broad ectodermal pluripotency in mouse embryos, suggesting a conserved mechanism across vertebrates. 7/7 🐥🐭
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Morpholino-mediated knockdown of individual pluripotency genes shows defects in “common stem cell regulation” whereas no signs of the pluripotency genes promoting a specific neural crest future lineage were detected, suggesting a lineage-independent role in neural crest formation
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scRNAseq data recapitulates the finding of maintenance of pluripotency signature from gastrula to end of neurulation, as well as the existence of pan-ectodermal stem cells. 5/7
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