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3) the basic pathology of renal amyloidosis- Congo Red and Fibrils that are randomly arranged
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8) Proteins that cause familial forms of amyloidosis are transthyretin (TTR), apolipoprotein-AI, apolipoprotein-AII, gelsolin, fibrinogen Aα-chain, lysozyme, leukocyte chemotactic factor 2 (LECT2)
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9) TTR amyloidosis- Peripheral neuropathy and cardiomyopathy are broadly described, and insights into disease reveal that kidney impairment and proteinuria are also clinical features( but very rare)
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10) TTR amyloidosis treatment causes anca vasculitis
Inotersen, a 2′-O-methoxyethyl–modified antisense oligonucleotide, inhibits hepatic production of transthyretin
Not with Patisiran (IV or SQ) and Tafamidis( Oral)
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13) Remember the new Leukocyte chemotactic factor 2 (LECT2) amyloidosis:
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14) Most common renal genetic amyloidosis is Fibrinogen A alpha chain -- recurrent risk high post renal transplant- need liver-kidney
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15) Picture says thousands words- Not all amyloid in the kidney is AL or AH---
-end
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@ginaguerrerob
Yes.. it has been reported.. look at this study can't say cause and effect as it was an autopsy study
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