Bryan Bishop
@kanzure
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mad science | bitcoin developer | cursor+aider maximalist | board @ LedgerX (MIAXdx) | co-founded Custodia Bank
Austin, TX
Joined December 2007
15 years of molecular nanotech, brain emulation, DNA synthesis, longevity, cryonics and more. Join the #hplusroadmap gc now available on discord https://t.co/pxxp6Ckv1g - work on cutting-edge technology development projects. Read more here:
discord.com
Check out the hplusroadmap community on Discord - hang out with 369 other members and enjoy free voice and text chat.
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Another case of cross-architecture non-determinism. Running a Windows cross-compiler, on x86_64 and aarch64, produces this difference in assembly, from the following (minified) code. Running on riscv matches x86_64. Noticed while updating our release compiler from GCC 13 to 14.
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Download them while you can
Open source achievements in 2025 DeepSeek V3.2 - $5.57M training cost, beats GPT-5 on math (96% AIME) GLM 4.6 - 200K context, excellent coding model Mistral 3 - 675B params running on ONE GPU Kimi K2 - 71% SWE-Bench, 1T params, agentic king Qwen3 - 119 languages, 1M token
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Ovarian time travel should be considered more often. Hormonal intervention can also rescue menopause (somewhat). For fertility, store eggs early.
we should avoid menopause at all costs! there’s a high variance of outcomes in menopause ofc but I’ve known some women that never regain their full wellness after. there actually is a way to reverse menopause with ovarian cryopreservation and the surgery has been implemented
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BREAKING: Bioethicists have scored a divisive victory today as they have now announced a UNANIMOUS PERMANENT BAN on biology.
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Vertically integrated manufacturing and productization of brain implants is something I didn't know I wanted. But it do be like that.
Neuralink co-founder DJ Seo: "One thing we'll continue to invest tons and tons of money towards is vertically integrating. Pretty much all the things you saw we build in-house; We have our own construction team to build custom buildings for ourselves. That's in Austin, where we
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A molecular nanotechnology startup just went completely dark and pulled all their AI work from github. What do they know? What did they see?
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Sounds like customers will have to take their embryos elsewhere to IVF & genetics friendly clinics. Or are we okay with clinics dictating reproductive decisions on behalf of parents? Making a list, checking it twice. Which clinics were naughty and nice?
Polygenic embryo screening is being marketed commercially – but how do IVF clinicians view it? • General approval is low (12%) For specific uses: • 59% approved of health-related embryo selection • 6% approved of trait-based selection 🧵 Survey findings in NPJ Genomic Medicine
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Even with really, really good artificial wombs, these machines still won't be capable of eliminating women from the human species. There are so many different preferences throughout humanity & you can't dictate their preferences. Even with a really good artificial womb!
This isn't anti gay btw - I think u can easily have two fathers who don't feel hatred towards the concept of a mother - I'm directly responding to all the posts I see abt how happy some ppl are to eliminate women from the human species.
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🚀 Launching DeepSeek-V3.2 & DeepSeek-V3.2-Speciale — Reasoning-first models built for agents! 🔹 DeepSeek-V3.2: Official successor to V3.2-Exp. Now live on App, Web & API. 🔹 DeepSeek-V3.2-Speciale: Pushing the boundaries of reasoning capabilities. API-only for now. 📄 Tech
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From 2015-2018, everything was "blockchain". Why? I think the people want tech progress. They want to see their institutions reformed. Appealing to blockchain was a cultural attempt at appealing to those values. But what if we just decided to not have a stuck society instead?
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All great things must first wear terrifying and monstrous masks in order to inscribe themselves on the hearts of humanity.
Kimi/Moonshot is so extra, they quote Nietzsche in their app updates.
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Time to get really, really good at engineering (if you aren't already)
Chinese realize you don’t need 4 nm process nodes if you just design good ASIC… what I’ve been saying for like 2 years now.
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Here's a description of how biology can colonize the whole galaxy, quickly.
Day 3/30 Underrated Ideas in Biotechnology In 1948, John von Neumann gave a series of lectures about “self-replicating automata.” His idea was to send self-replicating machines out into the Cosmos to explore distant planets and spread through the galaxy. Von Neumann’s automata
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Let me tell you a story about the ethicist that cried "wolf".....
@nstroustrup1 “No” is a fine response. “Stupid grifters” is the language I used elsewhere. My point is that the “No” is getting weaker because it’s overused. People who want to innovate hear “No” from everywhere in biotech all the time. Eventually they’ll just ignore it.
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Why not simply trade on different infrastructure from another market provider that doesn't suffer from this architectural flaw?
Overheated futures market require cooling down as CME faces outage at data center
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LLM providers figured out how to charge $0.001 for what used to be a free stackoverflow answer.
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