Joe Curran
@joe_curran1
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PhD student in the Nurse Lab @TheCrick. Interested in information processing in biology. Currently chasing a tiny protein around the cell cycle.
London, England
Joined August 2012
New preprint from our lab! 🎉 A phosphoproteomic adventure into how different phosphatases counteract CDK activity and how this can help to order substrate phosphorylation during the cell cycle. Find out more from first author, and my PhD lab partner in crime @TheresaZeisner
🚨New preprint🚨 How do phosphatases affect CDK substrate phosphorylation timing during the cell cycle? We showed that substrates dephosphorylated by different Ppases are phosphorylated at different times. 📖Read here: https://t.co/lx3MU8Wlf2 🧵Thread below
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Want to explore how your protein of interest interacts with loads of other proteins using AlphaFold3 but don't have time to analyse hundreds of predictions? I wrote a Python script that might help streamline the process! Check it out here:
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Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium! https://t.co/Mrz7Yrx1eU Check out the thread for an overview of the 9 #flywire papers published today
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We’re hiring! We have Wellcome-funded postdoc positions to join my group. The project will build on recent work on transcriptional cell size scaling (Swaffer et al. Cell 2023) to ask how gene expression, RNA metabolism and cell signalling are all coordinated with cell size (1/3)
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Great collaboration with the @DaveyLab on defining short linear motifs required for cell fitness using base editor screens. Hundreds of novel functional SLiMs to explore! A proteome-wide dependency map of protein interaction motifs
biorxiv.org
Short linear motifs (SLiMs) are the most ubiquitous protein interaction modules in the unstructured regions of the human proteome. Despite their central role in protein function, our understanding of...
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We’re presenting AlphaProteo: an AI system for designing novel proteins that bind more successfully to target molecules. 🧬 It could help scientists better understand how biological systems function, save time in research, advance drug design and more. 🧵 https://t.co/lx35RvplFr
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#Cellsize is important for many cellular processes, including biosynthesis, organelle homeostasis and development. If you need an overview of how cell size is controlled, and how it affects cell function, we have you covered: https://t.co/oSmHKzWzMv
@YagyaChadha @arohikhurana1
journals.physiology.org
Depending on cell type, environmental inputs, and disease, the cells in the human body can have widely different sizes. In recent years, it has become clear that cell size is a major regulator of...
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There's been amazing coverage of our new paper @Nature
https://t.co/qkrUksBYVW but I wanted to put together a walk-through (and make this accessible as possible). It's a bit long so get a cup of tea! The full version is open access so pls do have a read if you are interested...
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We thought there wasn't much new to learn about the cell cycle. Turns out we were wrong! Our paper (out today @Nature) identifies a novel alternative cell cycle that regulates differentiation, not cell division. https://t.co/ayDhJtKK6U. 1/10
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The latest pre-print from the lab is out, from the amazing @NitinKapadia27! Check out how he developed a new CDK activity sensor, uncovered the spatial dynamics of CDK activation at mitosis and probed the impact of this on the bistability of CDK activity in vivo!
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New paper out from my group https://t.co/Nd2wf2mQPn. CryoEM structure of the triplet polymerase ribozyme apoenzyme, with improved resolution from https://t.co/KsivdCigd5. Great collaboration with @mcrae_ewan and @esandersen
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Excited to co-feature in @MolecularCell with 4 studies @GabrielNeurohr @AdeSaurin @Alexis_Barr @_tonyly and @simakali1 labs on CDK inhibitor sensitivity – for anti-cancer efficacy bigger is better! Excellent preview on all 4 studies by @SchmollerLab
https://t.co/bX4DmCTSbO
cell.com
In this issue of Molecular Cell, Crozier et al.,1 Foy et al.,2 Manohar et al.,3 and Wilson et al.4 show how excessive cell growth caused by a temporary G1 arrest leads to permanent cell cycle exit at...
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Looking for an outstanding PhD? Check out our PhD program @TheCrick Many great labs and projects available. Excellent training including transferable, out of the lab skills. If you are interested in the interplay between cell division and differentiation,we are the lab for you!
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New paper from my group out in https://t.co/exum8zdZ0f. Outstanding work by Ben Porebski and great collaboration with https://t.co/xTxToaSswv. We describe a new high-throughput strategy for biomolecular discovery, which we call deep screening.
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Excited to see our work on how #mitochondrialDNA copy number is coupled to #cellsize finally out. Thanks to Anika, @frank_pado and the whole team @AlissaFinster @felix_thoma @osman !
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UK association with #HorizonEurope is finally confirmed! 🎉This agreement is thanks to the hard work of many people working to show the value of international collaboration during negotiations 🇬🇧🇪🇺
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PDRA opportunity in our group @UCLChemistry to develop & characterise ribozymes that harness primordial chemistries. 28 months, funded by BBSRC & Royal Society; org chem or mol bio background. Apply by 7th August: https://t.co/kXz8mIWXt5
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The Salk Cell Cycle Meeting will start in just 10 days (July 24th) and the list of all speakers, including short talks, is now available. https://t.co/5MvZIMT0pw If you can't be there, registration for virtual attendance is still possible! #CellCycle2023
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“Evolution of a minimal cell” in @Nature: https://t.co/LxEyxhaZfo Led by @RoyBoy432 with Brent Lehmkuhl at @IUBiology
@JCVenterInst collaborators: Lijie Sun, Daniela Bittencourt, Kim Wise, John Glass Along with @dschoolmaster, and Mike Lynch @ASUBiodesign
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