Jimmy Hu
@jimmy_k_hu
Followers
329
Following
453
Media
19
Statuses
284
Our group at UCLA studies the regulation of morphogenesis and regeneration by various signaling and mechanical cues.
Los Angeles, CA
Joined March 2014
Excited to share our new paper @PLOSGenetics that reveals how Shh signaling promotes myosin II activity to regulate tooth morphogenesis in mice!
journals.plos.org
Author summary During embryonic development, teeth, hair follicles, and glands are examples of ectodermally-derived organs that are formed from slightly thickened epithelial layers, called placodes....
5
8
35
🦷How do teeth grow? #NIDCR-supported research @UCSF showed that cell clusters in the developing jaw are literally squeezed into becoming tooth development centers in mice. The findings highlight how physical forces can sculpt organs & tissues. https://t.co/FjbnjMwDYi
0
5
10
Great to catch up with the best mentor @OphirKlein and dear friend @SharirAmnon This is What we do in the sushi-adows!
Great to have a chance to catch up with 2 terrific lab alumni @jimmy_k_hu and @SharirAmnon, and to hear about the work they are doing together studying rodent dentition! Also thanks to @TaikaWaititi for excellent help with the photography
0
0
11
Looking forward to reading this!!
Out today in @NatureMaterials, the updated version of our work on nuclear jamming in organogenesis 👁️🧠 Thanks to the reviewers (yes, thanks 😊), we have added a lot of new data. Check below for the new results... 🧵 ➡️ https://t.co/iLAdn8x2q2
1
0
1
Can't wait to read this! Congrats @JuliaHorsfield and team!!!
Happy to share @AnastasiaLabud1 PhD paper now out in @Dev_journal 🐟🧬 Cohesin composition and dosage independently affect early development in zebrafish https://t.co/nZFIRQQWIN - we show that cohesin 'amount' vs 'flavour' matters differently to zebrafish embryos!
0
0
2
Amazing effort and a lot of hard work from all the co-authors, especially @WeiDu322 , Adya Verma, and @LeahQianlinYe ! And thank you to the world's best mentor @OphirKlein ! Also thank you to @NIDCR for your support!
1
0
1
Myosin II mutants develop tooth phenotypes akin to those caused by Shh inhibition: a wide dental cord and a shallow epithelium. Together, these experiments unveiled how Shh promotes myosin II function to enable cell convergence and epithelial invagination.
1
0
2
We thus hypothesized that myosin II is responsible for mediating Shh's effect to promote tooth invagination. By deleting myosin IIA/IIB, we found that myosin II is required for the persistent convergent cell movement, as mutant cells reciprocate.
1
0
2
To drive invagination, dental epithelial cells undergo convergent movement to narrow the dental cord and push the epithelium downwards. But inhibition of Shh signaling disrupts this process.
1
0
2
When Shh is inhibited, the dental epithelium clearly can not invaginate effectively. There is also a reduction in AKT and myosin II activity. In fact, we found Shh signals through AKT to promote myosin II activation!
1
0
2
During early tooth development, Shh is secreted from a signaling center and it plays an important role in shaping the tooth epithelium, as previous studies have shown. But how?
1
0
5
Congrats Tyler!! I'll think about the gut next time my windshield is wet!
🚨🫧💧Online now in @CellCellPress, we define a mechanism that generates patterned curvature at tissue interfaces to begin building mammalian intestinal villi. @ZevGartner @OphirKlein Full text available here: https://t.co/RHYXOU3M3R Previous🧵👇with some splashy videos💧🫧
0
1
3
Congratulations Julia @californiajulia ! So glad to see this beautiful work out!
Very excited and proud to see our research @DOM_UCLA online @jclinicalinvest Check out the flow polarized signaling domains in endothelial cells captured by @SoongookHong
0
0
1
Thrilled to have this piece on the wonder, mystery, and very long history of #devbiol out in @aeonmag. https://t.co/iDGmoLPJtP
aeon.co
For 3,000 years, humans have struggled to understand the embryo. Now there is a revolution underway
25
91
305
Alexa is an amazing PI - if you are interested in developmental biology or evo/devo, look no further!!
Still time to apply to join my @ERC_Research NOVELTEETH @isemevol @CNRS I am looking for a postdoc in comparative genomics to implement spatial transcriptomics in bats. You'll have the opportunity to develop your own projects and will have up to 4 years of funding 👇
0
0
1
Excited to share this story from @OphirKlein & @CampasLab. I'm pre(tty)ssure this is what fun collaborations look like! It was great to work with everyone and Jeremy Green @jjbaglondon! Looking forward to our next!
Really excited to present the results of a great collaboration with the lab of @OphirKlein! 😃 A truly interdisciplinary effort, led by Neha and Pengfei, that reveals how tissue pressure sets the main tooth signaling center. Out today in @NatureCellBio ➡️ https://t.co/DsvPmFls6Y
1
1
11
Our Review on multiscale curvature is out in @NatRevPhys with @LucianoMarine1, @CaterinaTomba and @RouxLab : How multiscale curvature couples forces to cellular functions ? https://t.co/D2tIuO9zn9
6
40
140
#Cellpose 3! Not all images are perfect. Restore your images with Cellpose3 to get better segmentations, w/ @marius10p
https://t.co/7UGlkyaqRO
9
106
406