Paul Jenkins
@jenkins_paul
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Assistant Professor @umichmedicine , Pharmacology, Psychiatry, Neuroscience, Sports, Occasional trouble-making. He/him. Views are my own.
Ann Arbor, MI
Joined June 2011
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Pinned Tweet
Excited to finally have this published! Check out this work led by
@NeuroBender
postdoc extraordinaire and Jenkins lab alum, Dr. Andrew Nelson (who will likely be hitting the job market soon, hint hint).
Free until 3/19 here thanks to
@NeuroCellPress
:
New preprint just dropped from our group and
@NeuroBender
lab! Interested in how a pair of high-confidence autism spectrum disorder risk genes converge to cause similar synaptic deficits? Read below. A 🧵 1/
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I have been very open with my grant struggles on here. Many of you have been so supportive. Today, it came home to roost! On the first day of my 7th year on the 7th R01 submission. Thanks so much to all of my colleagues, collaborators, my chair, everyone. <sighs in whiskey>
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Man, reviewing PhD applications and the pandemic has just gutted undergraduate exposure to research experiences. We're going to need to adjust our expectations, accordingly.
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I am gutted. RIP to our first greyhound Kay Owens aka Owen. 2/20/2011-2/14/2024. He was the best dog I've ever had and the reason we've had 4 greys. I hate this part. I hope you're catching a rabbit with your brother, buddy. 💔😪
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Do not pet the fifth year PhD students
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I find that ranking students top 5%, 10%, etc. is not super useful and potentially ripe for bias, in general. But Stanford's ranking system is RIDICULOUS. Once in a generation talent??!, top 1-2%, top 3-5%??? Give. Me. A. Break. That is absurd.
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Man, the tables have really turned when you are sending figures to your former PhD student and they're like, "It's ok, but can you make it better?"🤣😓
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No one:
Literally no one:
NCBI: HERE'S THE NEW PUBMED YOU DIDN'T ASK FOR. IT'S GOING TO MAKE YOUR EYES BLEED AND KILL YOUR SOUL.
#bringbackoldpubmed
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I like how NIH isn't allowed to buy coffee for people, but this is apparently ok.
For decades, Justice Clarence Thomas has secretly accepted luxury trips from a major Republican donor, newly obtained documents and interviews show.
The extent and frequency of these apparent gifts to Thomas has no known precedent in modern SCOTUS history... 🧵👇
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Had a wild mouse loose in my office today. They really put C57BL/6J to shame in escapability and resourcefulness.
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Michigan Pharmacology and the science world in general has lost a titan. Ed Domino, a pioneer of psychopharmacology, active faculty member since 1953, first to introduce ketamine in humans has passed away.
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I don't know who needs to hear this, but fire the love of all things holy I would love to visit your department and speak in-person. I just want a fun lunch with trainees and crappy catered food and a nice dinner. And something that isn't Zoom.
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These two weeks in lab have reminded me of two things:
1) I love science. I had so much fun doing actual experiments.
2) I would be so much more useful for my lab if I could science with them instead of spending most of my time writing unsuccessful R01s.
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Come check out my poster today "Effects of 4 day high dose ethanol exposure on poster attendance"
#SfN19
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"The University of Michigan and the NIH will jointly invest $79 million to support and recruit 30 new faculty members to the Ann Arbor campus as part of a nationwide effort to enhance inclusion and equity across the biomedical and health sciences community." 🔥🔥🔥
University of Michigan and the NIH will jointly invest $79M to support and recruit 30 new faculty members to the Ann Arbor campus in the biomedical and health sciences fields.
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How it started vs how it's going: Jenkins lab lemon edition. Planted this tree in my office with the goal of getting the R01 before the tree bore fruit. Phew, that was close!
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My wife's transition to crazy plant lady is nearly complete.
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My girls with great-grandma. Plus our 16th anniversary. Heart is full today.
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I think our R21 just got a fundable score?! I'm not sure what to do right now. 12th percentile at NINDS.
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Me, as a postdoc: I don't understand why faculty never update their websites!
Me, now: Oh.
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@jayblackisfunny
@ddale8
I highly doubt that admiration would extend to women, in this case, given every indication he has ever shown.
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Heads up to those in Ann Arbor. We just received this horrific and cowardly threat. I'm encouraging our lab to stay home tomorrow. Stay safe, everyone.
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I am absolutely gutted. Came home tonight and our middle dog was acting odd. They think he had a brain tumor and he went downhill quickly. RIP Henry. We will miss you, buddy. You were the bestest boy.
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Made the decision to shutter the lab today. Finishing up last experiment with essential personnel and then closed completely Friday. It was the right call, but this is still agonizing. The next year is so critical for tenure. Ugh. Stay safe, all.
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15 years ago, we were just a couple of kids having fun in Michigan, getting married. Today we're still having fun! Happy Anniversary to my wife and partner in adventure!
#15years
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New lab photos! Sadly, our undergraduates were not available this day, but we'll get new ones with them soon too!
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I lost my grandfather last night (non-COVID). Even though it wasn't COVID, he wasn't able to see us or any family during the pandemic. He lived a long and happy life but his Parkinson's had gotten worse. I worry for my grandma who was with him for 70!! years. F#!* you, 2020.
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OMG how did I not know that my Amazon Prime membership gets me access to the Washington Post?
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Need some help troubleshooting this western blot. We keep getting this weird extra signal. Any thoughts?
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My mom, who has MS, got the first dose of BioNTECH/Pfizer today. HALLELUJAH.
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Friday Fireworks with the 2019 incoming Neuro PhD students! iGluSNFR in cultured rat hippocampal neurons.
#bootcamp
@rscjennie21
@mcwalicki
@_vegasnerve
@a_neurogenesis
@emmamaxtk
@Aheown
@BibiSulaman
@FurmanK8
@TheBigKat7
@M_Bassana
@ColdAssKatie
and others!
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I am crispy-fried burnt out. Extremely discouraged. Today is not a good day.
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New preprint just dropped from our group and
@NeuroBender
lab! Interested in how a pair of high-confidence autism spectrum disorder risk genes converge to cause similar synaptic deficits? Read below. A 🧵 1/
Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites
#bioRxiv
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What if the NIH ERA Commons has just been an extended, large-scale fear conditioning paradigm?
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Another R01 off into the ether. Suck less this time, score.
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My wife is sending me photos of the food in Greece and it is NOT OK.
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Is it possible for a grant to suck the soul out of you? Asking for a friend.
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Paper acceptance after two rounds of revisions is a pretty A-OK way to go into the holidays!
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There is just no way for a camera to fully capture the beauty of a Lake Michigan sunset. It's 63 degrees. In November.
#puremichigan
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Mice are an important model system as are worms, flies, human-derived cells, rats, marmosets, yeast, bacteria, computational systems, <insert model system here>. Each has their own advantages and caveats. All of them inform our understanding of basic biology.
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A heartfelt thanks to my friends, colleagues, mentors, and those who I have yet to meet IRL who reached out to me, sent supportive tweets, or shared their similar stories these last days. Your words meant more than you know. We will keep pushing and hopefully will get there.
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Officially on day 7 of having symptomatic COVID. 0/10, do not recommend. Nothing major, but feeling really run-down and foggy.
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It takes me 16 hours/year to get the figures in the right place on Microsoft Word.
How long does it take to write a grant? R01s are 13 pages of science: 3-4 are bespoke (say, 6-8 hours); the rest are aims that can be repurposed from content intended for a manuscript (another 6-8 hours). So ~16 hours dedicated time per grant.
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My favorite thing our grants office does is provide a 13-month status update to submitted grants so that we can relive the rejection one final fleeting time.
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Finding out that we were awarded a NARSAD Young(ish) Investigator grant from
@BBRFoundation
is a great way to wrap up vacation! Very grateful for foundation support, which has been critical for our lab. Especially this one and
@1mind4research
!
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I love my kids, but they generate more dishes in a day than the entirety of Denmark
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@djeowen
@jberkley17
@michaelianblack
@OhNoSheTwitnt
@TwitterSupport
The very rare double negative zero.
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We had the prettiest surprise snow last night. I love when it is so calm that it sticks to the trees! Winter is awesome.
#puremichigan
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Our first lab research paper is finally online at Molecular Psychiatry:
Ankyrin-G Regulates Forebrain Connectivity and Network Synchronization via Interaction with GABARAP
1/7
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Your model was a hamster and your funding smelt of elderberries.
PROPOSAL: Monty Python sketch about study section: The Knights Who Say NIH
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Getting a foundation NOA on the same day? Yes, this'll do. 😎
Paper acceptance after two rounds of revisions is a pretty A-OK way to go into the holidays!
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@boyntoncoaching
@ctmurphy1
@TheLancet
@markreidphysio
@AndyGovus
Condescending tone: check.
Leaving off female co-author in the tweet while citing all other authors: check.
Not a great start here...
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Are you even from the Midwest if you don't love watching thunderstorms?
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So I've lost 50 pounds since July. Set out to lose 20. 50 was a crazy pipe dream. Scored three goals last night. Might have something to do with it!
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Got to speak to my 6th grader's class today about the nervous system and our research. Showed them GFP, GCaMP, brainbow. Got great questions (all from girls
#girlpower
)! Really fun!
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I am especially disheartened that the three reviewers still had SIGNIFICANT concerns with this paper and yet it was still accepted, harmful conclusions and all.
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Well, he did it! Congrats to my very first PhD student, Dr. Andrew Nelson!! Great thesis defense. Can't wait to see what great things he does with
@NeuroBender
!
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Don't take acetaminophen to get over a hangover.
If students only retained one sentence from your lectures, what would you want it to be?
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I know this probably happens for every grant at Michigan, but I thought this was pretty cool! Not every day you get a letter from your US Representative. Thanks for the shout-out,
@RepDebDingell
! And thanks for being a strong supporter of basic science research!
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One year ago, I hit a number on the scale that I never thought I would hit. I was out of breath easily and just felt terrible, in general. Fast forward a year, and I am down 60 pounds. I have a neck again! Feel so much better.
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Today I met a lovely older couple at the supermarket. Upon reminding them they forgot their masks, I was greeted with "Fuck off".
#America
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@jenkins_paul
@MarinaP63
@marykaylobo
My dad is well known for keeping on top of all of the current neuroscience literature 😂
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The thing about science is sometimes you're the hammer, sometimes you're the assistant professor wondering what the hell you're going to do if this all doesn't work out.
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After this whole thing is over, I am going to start buying reagents from whatever company does NOT email me about webinars and COVID plans.
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See? There are repercussions for bad behavior in science!
<reads news>
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I will never tire of looking at this. Much better spatial resolution this year in
@NGPMichigan
Bootcamp with lower transduction levels of GCaMP7F from
@Addgene
. I love that you can easily see minis. So cool!! Image courtesy of
@CommanderPho
!
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Welp, off goes the R01 preliminary data supplement. Really excited about this project. This is definitely a "best foot forward" grant. All the fingers crossed for next month.
#goodvibes
#showmesomeones
#fortheloveofallthingsholy
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t-minus 2 days until summer lab BBQ. Brisket dry rub is in. I'll start the smoke with post oak tomorrow evening.
#nom
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My daughter soloed in choir tonight. Definitely cried a little. I hope she sticks with it because I think she has pipes.
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Big congrats to our lab's newest PhD CANDIDATES for passing their qualifying exams. Now the real fun begins! Congrats, Kendall and Carina!!
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I know some people say, "Don't send emails during non-work hours, use boomerang to send in the morning" but it stresses me out that my email inbox explodes right at 8am every day.
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It's NOA Friday! Smallish internal grant, but we'll take it!
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Tomorrow marks one year with our
@onepeloton
bike (and an off day). I've done 213 rides (just over 4/week on average). 108,853 calories burned. 2,381 miles in 125 hours. That's the distance from our house to Seattle. Thanks, terrified bike lady!
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Jenkins lab grad student, Julie Philippe, had her first-author review on protein palmitoylation and the control of substrate localization accepted today. Happy Friday!
#16carbons
#likeghrelinbuttwiceasnice
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Well this is certainly the best campsite I have ever had. We're alone out here!
#nosalt
#nosharks
#noworries
#puremichigan
#lakemichigan
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Congrats to Jenkins Lab 2nd year PhD student Kendall Dean on her wedding last weekend! Also, this is the most Jenkins lab wedding photo possible. 🤣🤣😍
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Good thread on some of the (many) problems with the recent
@naturecomms
paper on women mentors in science. The conclusion that increasing the proportion of female mentors is somehow HARMFUL to trainees is so insanely backwards I don't even know what to say.
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