Gamaleldin osman
@jamaleldin
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Neurologist, Epileptologist @Mayo Clinic, Rochester, MN. Tweets are my own.
Rochester, MN
Joined September 2009
Professor Matsumoto the world CCEP pioneer leading the discussion on use of CCEPs in IONM @ISIN course in Kyoto, Japan
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Check out this new collab w @MarcusVPinto @gabifpucci —> how 2 interpret Nerve Conduction Studies (NCS) For 1) neurology trainees & fellows 2) non-neuromuscular 💪neurologists 3) neurology APPs Bookmark for future and share with other 🧠s! https://t.co/hA1gkEETQ2
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Will temporal interference step into the spotlight in 2026 for Parkinson’s and beyond? Temporal interference refers to using two high-frequency electrical currents to create a lower-frequency stimulation that can non-invasively reach deeper brain regions. Demchenko and colleagues
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Could dentate nucleus DBS be applied to treat spinocerebellar ataxia (SCA)? Dentate nucleus is one of the key cerebellar output stations that helps shape coordinated movement by sending refined motor signals upstream in the brain. Zhao and colleagues describe in a new paper in
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GBA1 mutations and DBS: Folks, there’s more to the story. GBA1 refers to a gene that makes a product to help cells break down certain fats. Mutations in GBA1 are the most common genetic risk factor for Parkinson’s and can influence both motor and cognitive outcomes. Avenali and
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A new spark for steadier hands? An AI-Driven nerve stimulation eased essential tremor in a randomized study. Transcutaneous peripheral nerve stimulation (TPNS) is a technique that uses mild electrical impulses delivered through the skin to activate nerves in the arm and influence
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Are we ready to bring closed-loop neuromodulation into psychiatric disorders? Closed-loop neuromodulation refers to brain stimulation that automatically adjusts its output based on real-time neural feedback thus allowing therapy to be personalized to the brain’s state, rather
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Congratulations Omar Yagi- what an amazing journey indeed - inspiring! #science
“My parents could barely read or write. It’s been quite a journey, science allows you to do it.” New laureate Omar Yaghi was in the middle of changing flights when we reached him, just after he heard that he had been awarded the 2025 #NobelPrize in Chemistry. In this interview
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This is really cool. We don't really get "margins" in brain cancer surgery because you don't want to be resecting healthy brain (for obvious reasons), and because the nature of brain cancer is that it infiltrates healthy brain. This technology should allow surgeons to safetly
UCSF neurosurgeon Shawn Hervey-Jumper, MD, & his colleagues at @umichneuro have developed an intraoperative tool called FastGlioma that uses AI to help neurosurgeons see in real-time where tumor cells have infiltrated brain tissue. https://t.co/VZAfGhvQDq
https://t.co/Kd5rxQ3VHO
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new observations that further support the role of beta interactions within discrete limbic pathways in depression. some important similarities ( and clear differences) to our SCC DBS TRD cohort. looking forward to exploring further. great job andy !
Can we objectively distinguish between depressed vs. non-depressed temporal lobe #epilepsy patients? Seems like we can with #sEEG based Delta–beta inter-regional phase amplitude coupling. Amazing work by Ho Wing Chan and team including @HelenMaybergMD
https://t.co/PGX0z5Ades
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Can we objectively distinguish between depressed vs. non-depressed temporal lobe #epilepsy patients? Seems like we can with #sEEG based Delta–beta inter-regional phase amplitude coupling. Amazing work by Ho Wing Chan and team including @HelenMaybergMD
https://t.co/PGX0z5Ades
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Amazing stuff about #BCI and #Parkinson: "Invasive neurophysiology and whole #brain connectomics for neural decoding in patients with brain implants" https://t.co/HDRy7MyeR6
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A gene therapy buzz: Did AMT-130 really slow Huntington's disease by 75% at 36 months? A press release say YES. The data not yet been subjected to peer review and publication, however there has been so much buzz about this therapy, I wanted to summarize for folks what we know.
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A phenomenal team indeed !
The best team!
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I wonder now what neurologists who believe NPH is not a thing are thinking 🧐
To shunt or not to shunt, that is the (NPH) question? The first large randomized trial of shunting for normal pressure hydrocephalus (NPH) just dropped in NEJM, and there was clear benefit for walking, and it favored the group receiving shunts. Spoiler alert: Walking improved,
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Can connectomic DBS go beyond where to stimulate to inform who and when? Great presentation and discussion @DBSThinkTank with John Rolston and Julian Neumann suggests the answer is yes! @Brain_Circuits
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Out now - a roadmap to develop precision focused ultrasound in psychiatry, with a great team brought together by the @FUSFoundation. Interested in where the field is going? Check this out 👇👇
brainstimjrnl.com
Transcranial focused ultrasound (FUS) is an emerging neuromodulation modality that enables incisionless, spatially precise targeting of deep brain structures implicated in neuropsychiatric conditio...
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Can we fuse adaptive and connectomic DBS? @neumann_wj & I say yes. Out in @NatRevNeurol: https://t.co/FfMPh7Bykr Thread here: https://t.co/sMCFIMNufN
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Great read for enthusiasts of brains networks and/ or science fiction A fascinating review in Nature Review Neurology on the combination of adaptive DBS and connectomic DBS for optimal targeting and symptomatic improvement of specific symptoms. https://t.co/GUnNQ9nMEZ
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Mayo Clinic experts, with partners, developed an individualized ALS therapy for Dr. Rakesh Parekh — the first person in the world to receive a treatment targeting a CHCHD10 mutation. A bold step in precision medicine — halting disease progression and offering new hope.
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