Samay Pande
@iamsamayp
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Microbial ecology and evolution. Faculty at IISc Bangalore. @[email protected]
Bengaluru, India
Joined October 2010
New paper out in @ACSPublications Analytical Chemistry @an_chem ! We show that Raman spectroscopy can identify biochemical signatures of spores in Myxococcus xanthus, and that these signatures can predict germination efficiency across natural isolates. https://t.co/9PSmlLVJh4
pubs.acs.org
Due to the prevalence and importance of dormant microbial forms in regulating microbial ecosystems, the generation of dormant structures, like spores, has been extensively studied. However, several...
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@spp2389 A PhD position is available in my lab to work on: Emergence and self-organisation of bacterial metabolism in consortia of cross-feeding bacteria. Please RT Deadline: 12.11.25 More infos 👇 https://t.co/20vyiJIZbN
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Thrilled to be on the cover of @embojournal Odin rises from the Odinarchaeota yellowstonii genome, holding FtsZ1 and FtsZ2 the ancestral twins of tubulin highlighting their evolutionary divergence in Asgard archaea. 👉 https://t.co/kJZwSt8YA1
#archaea #evolution #cytoskeleton
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Only 3 day left to apply 👇
Only 10 days left to apply: We are searching for a senior postdoc (3 +3 years) in the field of theoretical ecology and evolution. You will have the opportunity to interact with experimentalists and develop own research projects. Please RT. Details: https://t.co/eABgl919XO
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Big thanks to Rekha (lead), an absolute rockstar who drove the project, and @JyoKalathera for pushing this work forward! Also grateful to our collaborator Prof. Siva Umapathy for the Raman spectroscopy expertise.
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This is one of the first demonstrations linking biochemical markers of spores to their germination efficiency, using a non-invasive, label-free approach.
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Most excitingly, these Raman spectral features of mature spores correlated strongly with germination efficiency across natural soil isolates of M. xanthus. Meaning: Raman spectra can serve as predictive markers of germination success.
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We found that: 1. Lipid and protein signatures shift dynamically during sporulation 2. Carotenoids accumulate in spores (stress protection!) 3. Nucleic acid signatures become compacted
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Using single-cell Raman spectroscopy, we tracked key biochemical changes (lipids, proteins, nucleic acids, carotenoids) as M. xanthus transitioned from vegetative cells into spores.
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Dormancy is one of the most widespread microbial survival strategies — from spores to persisters to VBNCs. But how do we predict which spores will successfully germinate and “wake up” again?
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Not many positions offer this rare combination: exciting research questions, a highly supportive work atmosphere, and an exceptional mentor @KostChristian. If you’re in theoretical biology and want to collaborate closely with experimentalists, this is it!
The position of a senior postdoc (3 +3 years) in the field of theoretical biology is available in my group. The post provides the opportunity to closely interact with experimentalists and develop own research projects. Please RT. Details 👇: https://t.co/P9M1AOL0zv
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Thrilled to have contributed to this exciting study on dual FtsZ proteins in Odinarchaeon from @syncellbiolab & Gayatri labs, with fantastic collaborations across groups!
🎉🍾Excited to share our #Asgardarchaea #odin #cytoskeleton study published in @embojournal Dual FtsZ proteins in Odinarchaeon form distinct filaments—shedding light on tubulin/FtsZ evolution. Brilliantly led by @Jayantikri23
https://t.co/nhj4xfNM1A
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Big kudos to @SaheliS95 , Sneha, and @Sharma__V ! Stay tuned for more stories on how microbial predation affects the evolution of resistance in pristine environments.
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Thus, microbial interactions in pristine environments can influence the evolvability of pathogens long before clinical antibiotic exposure.
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These findings are important because: Resistance traits arising under biotic stress may be less constrained, and potentially more evolutionarily potent, than those shaped in antibiotic-only settings.
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Our work demonstrates that coevolutionary history with a predator influences not only present-day survival but also the trajectory, speed, and cost of future adaptations, such as antibiotic resistance.
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While abiotic influences on evolvability have been widely studied, the historical contingencies of antagonisms, such as microbial predation, remain underexplored.
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Anti-predatory adaptations in E. coli were retained even after propagation in predator-free environments. These historical imprints persist and affect future evolutionary responses.
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And yet, if resistance does evolve in predator-adapted prey, it comes at a lower fitness cost than in other backgrounds. This means such resistance may spread faster in microbial populations.
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Key finding: Predation history restricts the evolution of high-level antibiotic resistance in prey bacteria, compared to those evolved only under abiotic conditions or wild-type controls.
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