Explore tweets tagged as #IBAD
A 22-year-old engineering student. And the dangerous lie of “curable” autoimmune disease. Last week, I met a patient I can’t stop thinking about. He is 22. Brilliant. Studying engineering at one of the best institutes in the country. He came with pain. Severe pain. Multiple
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Do you know about Type 2 SLE? 👉 Before understanding Type 2 SLE, you must first understand Type 1 SLE. 1️⃣ Type 1 SLE = the lupus we all know This is classic inflammatory lupus: High disease activity (↑ SLEDAI) Interferon-driven immune activation Monocytes, neutrophils, T
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How do we actually MEASURE lupus? SLE is not one disease, so one score can never be enough. This slide summarizes how we assess: • Disease activity • Flares • Treatment response • Treat-to-target states • Emerging trial endpoints If you treat lupus, you must know
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How many of us actually did BILAG for lupus activity? Be honest.Easy - BILAG is for you 👇 Not because it’s bad but because it’s hard to use. BILAG has the best science. Easy-BILAG fixed the interface. Common things first. Rare things only when needed. Final score visible
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It was my first year as a DM trainee in rheumatology. The OPD was busy, as it usually is. In the evening, I stepped out briefly for tea. Outside, I noticed a boy,around sixteen, sitting in a wheelchair. His posture suggested pain more than his expression did. His mother stood
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Some people like to compare different privacy projects For me, without any debate, the best privacy project today is Seismic Why Seismic is different, next 👇
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The Story of Courage That Leads to Hope for Many: Emily, the Angel Girl Leukemia begins silently, inside the bone marrow, where blood is meant to be born. In Emily, it was a B lymphocyte that forgot its purpose. A cell designed to defend life began multiplying without meaning,
Did anyone think lupus could be curable? CART-cell therapy in refractory SLE: • 10 studies | 47 patients • 81% achieved LLDAS • Marked improvement in disease activity & serology • Consistent B-cell depletion → gradual immune reconstitution • CRS common but mostly
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“Have you seen Raynaud’s phenomenon in the thumb?” If you have -stop. Look again. Think deeper.👇 Let’s start with the rule 👉 In classic Raynaud’s, the thumb is usually spared. That’s not folklore, it’s consistently described in reviews and imaging studies. Now the WHY
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A concept shift in post-MI care (read carefully) 👇 β-blockers don’t work because “MI happened.” They work because the ventricle is vulnerable. 📊 JAMA Cardiology 2026 meta-analysis (≈20,000 patients): • Acute MI • Preserved LVEF ≥50% • PCI + modern GDMT 🔍 Result? No
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Grateful. Spoke on translational science in lupus at Rheumatology Updates 2026 (VRA), Tadoba, Maharashtra Key ideas shared: • Monogenic lupus is real • IFN biology goes beyond Type I • Cytokines ≠ just interferons • Omics (esp. transcriptomics) will redefine SLE •
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“Is IL-6 inflammatory or anti-inflammatory?” That question sounds basic. But if you don’t understand it, tocilizumab side effects will always feel like paradoxes. Let me tell you the IL-6 story the way biology actually works. IL-6 was not designed to cause disease. It evolved
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What happens when we stop adalimumab in JIA-associated uveitis? The ADJUST trial gives a clear answer. • 68% relapsed within 48 weeks • Most relapses occurred within 6 months • Relapse was driven by uveitis, not arthritis Longer prior remission did not reduce relapse
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The TLR7–TLR9 paradox in lupus 1-The mystery Both TLR7 and TLR9 sit in endosomes. Both sense nucleic acids. Yet in lupus: •TLR7 worsens disease •TLR9 protects Why? 2-The key experiment Researchers did something elegant: 🔄 They swapped only the TIR (signaling) domains
Pattern recognition receptors play a key role in innate immunity… aren’t always villains in autoimmune diseases. In lupus, one is the enemy… one is the friend. 🔴 TLR7 → fuels lupus nephritis 🔵 TLR9 → unexpectedly protective Same family. Opposite outcomes. Immunology is
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Recently in Nature review , they published an interesting study on a new monogenic lupus. What’s fascinating is how TLR7 goes out of control — and why this can look like routine SLE. 👇 1-Let’s start with TLR7. TLR7 is an innate immune sensor inside cells. Its job: 👉 detect
The TLR7–TLR9 paradox in lupus 1-The mystery Both TLR7 and TLR9 sit in endosomes. Both sense nucleic acids. Yet in lupus: •TLR7 worsens disease •TLR9 protects Why? 2-The key experiment Researchers did something elegant: 🔄 They swapped only the TIR (signaling) domains
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Ibn Al Qayyim رحمه الله said: "A woman who takes you away from Allah is a punishment, not a blessing, even if she pleases your eyes." [Zad al-Ma'ad fi Hadyi Khayr al-'Ibad] May Allah fill our hearts with contentment in His obedience, protect us from deceptive attachments, and
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