Happy to announce that the joint symposium on lysosomes and autophagy by the ESGLD and the DFG research unit FOR2625 will be held in Berlin, Germany this year in June. Please share and re-tweet😊 Registration and abstract submission opens June 31st, save the date! #lysosomes

Registration is open NOW for our joint symposium on lysosomes and autophagy by the DFG research unit FOR2625 and the ESGLD in Berlin, Germany in June. Don't wait too long as the number of participants is limited... Please share and re-tweet! See you in Berlin 🥳 #lysosomes

And here a glimpse of what you can expect, the list of currently confirmed speakers...

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Registration for the ESGLD 2022 workshop and graduate course on #lysosomes and related disorders is open now, check it out: https://t.co/njKh4hTG0T

There are still some days left to sign up for the back to back symposia of the ESGLD and FOR2625 on #lysosomes and #autophagy in 2 months in Berlin! Registration closes on the 15th of April at midnight, so dont wait if you want to join us! Looking forward to see you there!😀

🤔 Now it's time for a drug repositioning study: Nicolina Cristina Sorrentino is showing us her team's promising results on the use of a well-known antidepressant to ameliorate the systemic pathology in a mouse model of MSD. 🐁🔍

🧐Time to have yet another look over Fluoxetine's potential for drug repositioning in #lysosomalstoragediseases. 🤔 Who would have thought this long-known antidepressant would have a role to play on the search of a treatment for MPS IIIA❔❕ 💊🐁🔍

🧐 Time to go technical, now, and get an insight on the fine-tuned, super strict process behind the manufacture of a stem cell gene therapy in house. 🧬🔬

Yet another promising therapeutic approach: ex-vivo expanded muscle regenerative cells for transplantation in Pompe disease 🧐 Stay tuned for Gerben Schaaf's talk on this exciting work❕

And now Fabio Dell'Aquila brings us an exciting proof of concept on CRISPR/Cas9-triggered homology-independent targeted integration in vivo, in a mouse model og MPS VI. 💠🧬➡️💉🐁 Great results, Fabio! Keep on the good work ❕👏🏻

Inês and Elizeth, are in Berlin for the 25th ESGLD Workshop and FOR2625 Lysosomes & Autophagy Symposium! Inês gave an oral presentation at the ESGLD, and both presented posters at the FOR2625. Grateful to the organizers for granting us a travel grant. #ESGLD2024 #FOR2625

Happy to announce the first speaker of our new webinar series of the @ESGLD_tweets: Andrea Ballabio. This series of webinars will feature prominent scientists in lysosome research, so if you are interested in lysosomes and their roles in human disease, don't miss it!

Time to close this morning's excellent session, with a talk on disease modeling. Let's listen to Silvija Tokic telling us all about her novel cell model for Fabry disease: primary endothelial colony forming cells 🧫🔍

🧐 Yet another worth-watching technical set-up, this time focused on the development of an appropriate method for AAV delivery in vivo. The whole thing relies on a real-time monitoring system for targeted catheter placement & optimization of flow rate and pressure. 💉🧠➡️🖥️📌

Now moving into the clinic, guided by the hand of Charlotte Aries, who's showing us some nice & moving results on the use of Ambroxol both as a monotherapy and as a combination one in real-life Gaucher disease type2 patients 👏🏻 💊👶🏻➡️👩🏻‍⚕️🩺 Unbelievable results, congratulations❕

Starting day 3 of this exciting #ESGDLWorkshop with a story of success ❕ ⬇️ Time to hear the amazing Volkmar Gieselmann telling us how his team managed to design & test an improved version of arylsulfatase A for ERT. 🧫🔬➡️💉🩺

We're back from our coffee break and ready to learn more on yet another attempt to ameliorate brain pathology in #lysosomalstoragediseases: the development of an IGF2-tagged enzyme for Pompe disease 💉🐁 Great set of data, Fabio Catalano❕

Tomorrow is our first ESGLD webinar with the awesome lysosome man himself, Andrea Ballabio! Don't miss it! For the login details please email us via secretary@esgld.org...