Dr. Strickler with long term updates from CodeBreaK 101, sotorasib + panitumumab and FOLFIRI 2L KRAS G12C mutated mCRC. OS was 15.6 months. CodeBreaK 301 (Phase III) study ongoing. #ASCO25

Overall Survival Analysis of CodeBreaK 300 Study of Sotorasib + Panitumumab vs Investigator’s Choice in Chemorefractory KRAS G12C CRC.@JCO_ASCO .👉not OS benefit, but PFS & ORR improved.🧐A bit disappointing, but overall supportive. CodeBreaK 301 awaited

Long-term safety & efficacy of sotorasib plus panitumumab + FOLFIRI for previously treated KRAS G12C mCRC:.#ASCO25.🔎CodeBreaK 101 phase 1b.👉ORR 57%, DCR 92%.👉mPFS 8.2 mo.👉mOS 15.6 mo.👉TRAE>3° 50%.🧐 Looks effective, manageable AEs, looking forward to 1st line data.@myESMO

//Reactivate= ["Cipher_Sequence"]."Target: Hackers"; Mission.Scope {"codebreak"}

Project 863: CODEBREAK's Title Screen (W.I.P). #project863 @OnlyOverkill

Codebreak Fiat Keynes; Reap Bitcoin Gains. —this is a good book btw; I think its a classic

🚨Highlights from #ESMO2024! Dr Francesco Sclafani shares key results from four important trials in metastatic colorectal cancer, including updates on the SOLARIS, POCHY, and CodeBreak 101 studies.

"I Am The Absolute" (Project 863: CODEBREAK Teaser). #project863 #teaser

Project 863: CODEBREAK (Reveal Teaser). #Project863 #Teaser @OnlyOverkill

Two new Maverick Hunters;. Codebreak "Cody" Croc & Veloci "Velo" Rapier, The Walking Talking Computer Room & The Bishonen Robo Dino Anime Swordsman Ever. #megamanx #megamanoc #megaman_oc #maverickhunter #ロックマンX #オリジナルキャラクター

"March 5th" (Project 863: CODEBREAK). #project863 @OnlyOverkill

The calculated way John D. Rockefeller eliminated his first business partner reveals everything about strategic patience:

FDA approves sotorasib with panitumumab for KRAS G12C-mutated colorectal cancer.👉Based on CodeBreaK 300.👉mPFS 5.6 vs 2 mo, ORR 26% vs 0, no OS benefit most likely due to crossover.🧐Looking forward to see data in earlier lines. @myESMO

Sometimes I look at my boss and just wanna codebreak his shit followed by the walls of Jericho. 😭😭

Molecular Determinants of Sotorasib Efficacy in KRAS G12C-Mutated NSCLC (CodeBreaK 100&200). TTF1 Low vs. High❗️.ORR➡️4% vs. 42%.PFS➡️2.76 vs. 8.11 mo.OS➡️4.47 vs. 16 mo. Other: KEAP1 mutations, ATM status, transcriptional subtypes, and ctDNA clearance.

Dr. Strickler PhIb CodeBreak101 in 2L+ #KRASG12C MT #mCRC ➡️ n=40 at Soto 960 mg QD + standard dose FOLFIRI + pmab (50% had PD w/irino before) ORR 55% w/prior irino PD, PFS 8.2 mos, OS 15.6 mos. No new safety signals. PhIII underway CodeBreaK 301 #ASCO25 . @OncoAlert

Excellent news that Bill Tutte is being commemorated on a VE-80 stamp. What a pity that the Post Office doesn't seem to know that 'codebreak' isn't a verb and that codes and ciphers are different. If only there was a national agency that they could have approached for advice .

How a teenage bookkeeper learned to turn data into dominance (and why your spreadsheets are your secret weapon).

My personal reflection on purpose, passion, skill & value as a developer . Ikigai (生き甲斐) is the reason you wake up feeling aligned. Check it out #wekigaii_tribe #buildinpublic #frontenddev #wekigaii_tribe.#wekigaii_community.