Tricky to manage brain mets, here’s some added complexity from my colleagues ⁦⁦@DanaFarber⁩: Association of Neurosurgical Resection With Development of Pachymeningeal Seeding in Patients With Brain Metastases. | JAMA Oncology Tweet added by Geoff Oxnard MD @geoff_oxnard

Geoff Oxnard MD

5 years

Tricky to manage brain mets, here’s some added complexity from my colleagues ⁦⁦ @DanaFarber ⁩: Association of Neurosurgical Resection With Development of Pachymeningeal Seeding in Patients With Brain Metastases. | JAMA Oncology

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Stephen V Liu, MD

@StephenVLiu

5 years

@geoff_oxnard @DanaFarber Fascinating downstream consequences of SBRT advances; authors suggest some role for WBRT post-resection. Need to account for biology though, with highly CNS active agents available for EGFR, ALK, ROS1, etc. Also wonder what impact immunotherapy has here. Great work. #LCSM

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Daniel Cagney

@DanielCagney

5 years

@geoff_oxnard @DanaFarber Thanks Geoff. Although representing a small proportion of total patients who undergo resection the worrying aspect is that pachymeningeal failure is more common in patients with controlled or absent extracranial disease.

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