Natalia T Freund
@freund_lab
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Immunologist, Principal Investigator @ Tel Aviv University. Interested in the human antibody response towards diseases. #COVID19 #SARSCOV2 #HIV1 #Tuberculosis
Israel
Joined April 2018
Our #Tuberculosis story is finally out!🥳🍾 We isolated 2 #antibodies from an infected patient, solved their structures and showed they protect mice from a pathogenic Tb challenge. Such a long endeavor but I am thrilled with the result! @javid_lab
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The Israeli spirit of freedom will not be broken. We will keep creating, thinking, investigating, researching. We will eventually win these psychos Ayatollahs who has been aiming to destroy Israel and all free world for so long.
This is the most Israeli thing I’ve seen. Taken at the Weizmann Institute of Science, following the Iranian attack.
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RT @freund_lab: 1/3 Proud to share our work published in @JCI_insight focusing on antibodies to cancer. #MET is a long-known factor involv….
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Another study from our lab💥🎊🍾 led by the super talented #MDPhD student @ron_yefet. He found a new target for neutralizing antibodies that attack #Mpox virus, discovered the mechanism and tested them in mice. A collab with @institutpasteur @Guardado_Calvo @Virus_Immunity.
1/11 New preprint alert! Our latest @freund_lab study in which we dissect how the immune system fights #Mpox and identify potent human neutralizing monoclonal antibodies (#mAbs) that target a novel key viral protein, #MpoxA28. Now on biorxiv: �.
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3/3 This study was initiated by @MMordekovich then audaciously led by @navon_michal with amazing effort and help from @Noam_Ben_Shalom and alongside many other, and especially our wonderful team of collaborators in @HospitalSheba the brilliant @MayaDadiani and Einav Gal Yam.
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2/3 We analyzed a cohort of cancer patients and found that 10-13% or patient develop serum Abs to MET. We isolated anti-MET B cells and Abs, finding that these Abs are polyreactive and exhibit decreased stability. Nevertheless, they compete with HGF and inhibit cancer cells.
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1/3 Proud to share our work published in @JCI_insight focusing on antibodies to cancer. #MET is a long-known factor involved in cancer, and a target for #cancer therapy, but natural #Abs developed to this receptor during cancer were not described.
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My lab is recruiting! We are looking for an excellent graduate student (MSc or PhD) to work on single cell analysis project involving B cells in health and disease. If you are passionate about single cell genomics, vaccines and antibody development, please contact me.
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Today was @Noam_Ben_Shalom's last day in my lab. I'm so honored to have been his mentor. As @ZivShulman once told me, the biggest achievement is producing great students and scientists. Noam, I wish you all the best in your postdoc at @WashU! We will miss you! #proudPI #PhDone
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OMG 😱.
Exclusive: These universities have the most retracted scientific articles. A first-of-its-kind analysis reveals which institutions are retraction hotspots. Read the full story here:
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��It’s going to be a fantastic meeting, there are still some spots left. Sign in by the end of the month for earlybird rates #antibodies #complement #scientificconference #therapeuticantibodies @roumenina @ZivShulman @DahanLab @carovinuesa @MOUQUETHugo1 @javid_lab @NussenzweigL
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🤣🤣.
It costs $12,690.00 to publish open access at Nature. You could buy an entire car instead. Here is a thread of literally anything else you could spend that money on. 🧵1/10
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💥💥💥The 4th edition of the Antibodies & Complement will take place in Sicily May 26-30, 2025. Registration is open (and spots are filling up fast, last 2 editions were fully booked) SCHOLARSHIP POSSIBILITY for selected Students and Post-Docs✨💫.
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Happy Hannukah 🕎 and merry Christmas 🎄 from the @freund_lab the greatest team 💪🏽and thanks @leshem_amir for the wonderful photos taken during our lab fun day in beautiful Jerusalem
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Having cocktails for lunch with the B cell king 👑 @ZivShulman Talking about, antibodies, families, our past&future, and how science life is still the best 💫
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Congratulations Ronit and team, happy to see it out, and thank you for including us!.
Exciting breakthrough in vaccine technology! Our study published in collaboration with @FlorindoLab laboratory at the University of Lisbon, has made it to the cover of Advanced Science of @WileyGlobal!.Congrats to Rita Acúrcio, Ron Kleiner, Daniella Vaskovich-Koubi and team! 1/3
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My amazing friend @Yael_David__ I am always inspired reading your interviews and your perspective on things.
Thank you @ampepsoc for featuring us in the November issue of “Lab of the Month”! . Thank you @AnnaKnoer & @YangXiao_TPCB for putting it together, & the David lab for being the best group of people to work with 🙏🏻🫶🏻. @MSKCancerCenter @WeillCornell .
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Spent the last two days at the annual #ISM meeting organized by @DrDorSalomon @StructureRocks @MeitalGal. I met so many collaborators, colleagues and old friends. Our community generates great science, wonderful ideas and has such an important impact.
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Interesting story from @MOUQUETHugo1 about how antibodies produced by B regs in the neonate regulate early microbiome diversity. Cool stuff!.
nBregs & early-life microbiota.Newborn regulatory B cells (nBreg) autocrinally regulate IgM via IL-10. mAbs from intestinal nBregs react against diverse bacteria, highlighting role of nBreg Abs in microbial diversity & early-life microbiota communities.
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Inherited TNF deficiency is a new genetic aetiology of recurrent pulmonary TB in adults. What about induced (therapeutic) TNF blockade in LTBI individuals or those living in TB endemic regions?.
1/ Exactly one year after my PhD defense, I am very excited to share with you the last chapter of my thesis published today in @Nature about humans with inherited TNF deficiency:
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A new approach to single cell sort and sequence antigen-specific plasma cells.
@hollfelderlab @Thav_Lab @Cambridge_Uni @CamBiochem @MedCambridge @OPIGlets @BiolUW @NHSBT New technology enables faster response to disease outbreaks like COVID-19 #NBTintheNews via @CamBiochem
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