Esben Agerbo
@eagerbo
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Statistician – professor at Aarhus University
Joined January 2010
🙌 And to @NCRRCBP, Marianne Pedersen, @sussieantonsen, Emil Pedersen, @HorsdalThisted, Jean-Christophe Debost, @BoPreben, Liselotte Petersen, @bvilhjal, Jørgen Feldbæk Nielsen, Jeppe Klok Due, Anders Søgaard, @christian_igel, Wes Thompson, Chun Fan, @WrayNaomi, @John_J_McGrath
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Using Danish data on >3M people, we estimate absolute and relative risks, heritability & non-familial cases
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💡Why it matters: • Family history alone can’t identify most cases • We need both population-level and personalized strategies
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Highly heritable: 45% (depression) to 77% (cannabis use disorder)
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People with affected 1st/2nd-degree relatives have higher risk • Yet most cases are non-familial: ▫ 89% schizophrenia ▫ 60% depression ▫ 96% schizoaffective
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🔗“Absolute and relative risks of mental disorders in families: a Danish register-based study” 👉 https://t.co/SNFgypJMhC 📌Key findings: • Mental disorders are highly heritable – but most cases have no family history
thelancet.com
Individuals with family members with a mental disorder face increased risks of the same disorder. From a population perspective, most mental disorders occur in individuals without affected close...
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5 hurtige tips til ansøgninger om Sundhedsdatavidenskabelige (SDV) projekter hos #NVK Læs mere på https://t.co/B0SwZo5fBz
#dkforsk
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The Danish Civil Registration System versus the lite Danish Multi-Generation Register. New paper by @NCRRCBP and folks
1/n Familial aggregation studies of diseases rely on familial information linked with health records. We investigated the completeness of familial links in the Danish Civil Registration System and described the future Danish Multi-Generation Register https://t.co/605MiK1O2c
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Congratulations, Emil – beautiful presentation, impressive work! @EmilP94637497 did an excellent job defending his PhD entitled: ”Leveraging family history and age-of-onset to boost GWAS power and disorder prediction”. Great discussion by the opponents @zkutalik, @michelnivard
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Intriguing new statistical approach to distinguish between polygenic, de novo and Mendelian tail architecture via sibling gwas data
Landmark new genetics manuscript just dropped. https://t.co/65lqFAnhIW
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GWAS of ADHD by @DemontisDitte, @AndersBorglum and team identified 27 genome-wide significant loci, show that 84–98% of ADHD-influencing variants are shared with other psychiatric disorders, and much more. https://t.co/5XsXonYtHR
nature.com
Nature Genetics - Genome-wide analyses identify 27 loci associated with attention-deficit hyperactivity disorder and provide insights into its genetic architecture in relation to other psychiatric...
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Great to see this splendid, interesting and rich paper by tweetorial virtuoso @doctorveera. Well worth a read!
Better late than never. Happy and relieved to share a final published version of one of my PhD projects in which we uncovered a fascinating genetic link between language ability, psychiatric risk and creativity. 🧵 https://t.co/n8lsZmhIw9
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Who’s ready for an exposé of statistical reviews over Christmas? Sneak preview of our stocking filler coming out in a few days in BMJ …
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Individuals with mental disorders lose 10·5 years of working life. Those with schizophrenia, mood, neurotic, eating disorders lose 18.9, 10.3 and 6.7 yrs
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We would like to share with you our recently published article “Identification of shared and differentiating genetic risk for autism spectrum disorder, attention deficit hyperactivity disorder, and case subgroups.” https://t.co/bJL9oze8FO… Details below.
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