Delighted to share our paper ➡️Increased somatic mutation burdens in normal human cells due to defective DNA polymerases https://t.co/uDo1cEz39n Implications for our understanding of cancer risk and the somatic mutation theory of #ageing 🧵⬇️

Stem cell transplants are amazing. A patient's diseased blood is replaced by a relative or stranger's. But what does putting a blood system into a new body do to the cells? How many survive? Does it matter? Out in @Nature today, we asked some basic Qs 👇 https://t.co/anRQGeo2qq

Looking for PhD students/postdocs for my newly opened lab at the Institute of Human Biology of #Roche in Basel. We work on human lung, liver and gut #organoids. Send email + CV + motivation letter to hans.clevers@roche.com with header #IHB https://t.co/5Ki03fy4NH

Gareth Southgate’s greatest achievement was not on the pitch, but in the standard that he has set for how a role-model and representative of our country should conduct themselves. In a job which has subjected him to a degree of national scrutiny and criticism that most people

We did an internal experiment using LLMs to parse and visualise ORRs from AACR clinical trial abstracts. Worked pretty well; check out the results in the link (click the bubbles to open the relevant abstract) https://t.co/EsahwLAHsH

This super paper examines the ways in which gene therapy and stem cell transplant change this delicate balance of cellular competition and explains why blood cancers arise in these patients. Big hurrah, great job @doctor_msc and colleagues !! 2/2

In the perpetual struggle for dominance, populations of cells in normal healthy tissues seek out ways to outcompete their neighbours. We know that medical treatments can alter this dynamic. 1/2

Gene therapy is big news! https://t.co/XhEOegAjCs and a major advance for patients with sickle cell disease (SCD) & thalassemia. But in some recent trials, a small number of patients developed blood cancer. Our study (out in @NatureMedicine ) asked why... https://t.co/pos7Eqiurn

🚨For the 4th day in a row, the @IDF opened an evacuation corridor for civilians in northern Gaza to move southwards. Since 10:00 am today, thousands of Gazans passed through. The corridor will be open until 14:00 so that Gazans in the north can evacuate for their safety.

The IDF is facilitating the delivery of humanitarian aid to Gazan civilians through @cogatonline COGAT’s Spokeswoman Shani Sasson shares more details:

An Al Jazeera broadcast documented the moment that the Islamic Jihad launched a rocket which misfired and hit a hospital in Gaza, killing hundreds.

If anyone at #AACR23 wants to catch up, I'm presenting my project in one of the minisymposiums :) Mutational processes in normal kidneys from multiple countries with varying kidney cancer incidence rates Tangerine Ballroom 1 Sunday Apr 16, 4:06 - 4:21PM @CancerGrand #Mutographs

Many Congrats, so excited to see these great projects funded and can't wait to see the results!

What drives clonal expansion (CE) in humans? How do they relate to the developmental process of cancer? What sets their growth limits? Happy to share our review. @Sanne and I set out to delve deeper into these questions. Warning: long read. https://t.co/Jgl5RcE51U

The FT not the BMA published this. How can this salary assault on NHS and Education staff be justified. And how long do the professionals endure, in sacrifice for their guardianship of patients and children. Think how manipulative & morally horrific this regime is.

❓Ever wondered why small bowel cancer is so rare...so do we... 🔬here we investigate whether somatic mutation rates might explain it... 🧬along the way we came across a fascinating diversity of mutation processes occurring in HEALTHY bowel ⬇️ @sangerinstitute @Cambridge_Uni

The rumors are true: I will teach Bayes & causal inf again starting in Jan 2023. Online, flipped format. Sign-ups end of this month. Mammals at @MPI_EVA_Leipzig and @idiv will get first pass. Then I'll open up to all. Last year's course:

Today, we’re introducing a new model that eliminates accept/reject decisions. By publishing every paper with eLife reviews as a Reviewed Preprint, we plan to restore autonomy to authors, ensuring that they will be judged by what, not where, they publish. https://t.co/OAsiOVFStI

Many Congrats Mia! Really great paper with v. important discovery!

Our new study about somatic mutagenesis in #MUTYH, would be really glad if you might consider sharing it! @StMarksHospital @CGAIGC @insightmeeting @HHampel1 @EHTG_Tweets