The nitrate transceptor NRT1.1 detects external nitrate levels to regulate nitrate-induced transcriptional responses, auxin transport, and phosphate starvation responses in plants. A study by Ma et...

Shen et al. demonstrate that the miRNA degradation-related proteins SDN1–3 degrade miRNAs targeting ECS in egg cells, thereby ensuring the normal expression of ECS1/2. This enables the fertilized egg...

To investigate gonadal somatic cell lineage specification in humans, Lardenois, Suglia, et al. combine single-cell transcriptomics, trajectory analyses, and organotypic cultures. They identify...

Huang et al. report that auxin drives the assembly of its cell-surface receptors, TMKs, with efflux carrier PIN1 at the plasma membrane, creating a self-organizing module. This receptor-transporter...

Zhu et al. uncover an evolutionarily conserved water transport pathway in the epidermis of plant shoot meristems that maintains water homeostasis and regulates stem cell activity. This epidermal...

Yang et al. generate hepatic stellate cells (HSCs) from hiPSCs that recapitulate key characteristics of human fetal HSCs. Using a Matrigel-free liver organoid system, they show that hiPSC-HSCs...

Patients with DICER1 cancer predisposition typically harbor a germline heterozygous inactivating mutation in DICER1. Whether DICER1 mutant non-cancerous cells contribute to tumor promotion was...

Through single-cell analysis of mouse small intestine development, Jiang et al. identify a population of mesenchymal progenitor cells as the developmental origin of intestinal telocytes. These cells...

Mammalian zygotes inherit asymmetric levels of CENP-A between parental centromeres, which are remodeled during the first cell cycle to equalize CENP-A levels prior to zygotic mitosis using maternally...

Herszterg et al. show that during morphogenesis of the Drosophila pupal wing, a wave of Notch signaling activity updates cell fates to ensure robust and precise patterning of wing veins.

Petry et al. demonstrate a defined migration route of microglia progenitors from the surrounding mesenchyme into the embryonic CNS. This process relies on integrin activation and interactions with...

Oberst and Xu et al. identify cholesterol imbalance as a shared driver of neuronal dysfunction across genetic and environmental risk factors for depression. Their findings suggest that diverse causes...

Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4...