DEEPTHI RAMESH
@deepthiramesh92
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Postdoc Scholar @UCSF Medicinal chemistry, Oncology, Virology, Infectious diseases, NTDs, Biopolymers, Small molecule drug discovery, Organic synthesis
University of California
Joined September 2021
Workflow for E3 Ligase Ligand Validation for PROTAC Development | ACS Chemical Biology
pubs.acs.org
Proteolysis targeting chimeras (PROTACs) have gained considerable attention as a new modality in drug discovery. The development of PROTACs has been mainly focused on using CRBN (Cereblon) and VHL...
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Here are the ten approved HIV protease medicines. The first nine all used the same design strategy to address the flap water. The last took the alternate approach and replaced it. https://t.co/r5hpB7GbpK
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Celebrating new publication. We demonstrate novel #imidamide based linkage for attaching #smallmolecules based on #drugdesign principles to #chitosan. https://t.co/nGk0oqkLWg
#polymer #biomaterial #Researchpaper #postdoc #Chemistry #biopolymer
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DEL-Dock: Molecular Docking-Enabled Modeling of DNA-Encoded Libraries #MolecularDynamics
https://t.co/B0McyTMMTR
@KShmilovich @Tkaraletsos Vol63 Issue9 #JCIM #compchem
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Seeking postdoc position #polymer #medicinal #biomaterial #postdoc Please feel free to reach out if you have any inquiries or potential opportunities to discuss. https://t.co/rvqYSnv88i
https://t.co/0qgSIpBNwU
https://t.co/H6KgrbGLTo
https://t.co/gCRxw29eZs
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Incredibly useful "cheatsheet" on cancer chemotherapy classes. From Cell Press https://t.co/A19G0Weag5
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Discovery of an Oral, Beyond-Rule-of-Five #Mcl-1 Protein–Protein Interaction Modulator with the Potential of Treating Hematological Malignancies
pubs.acs.org
Avoidance of apoptosis is critical for the development and sustained growth of tumors. The pro-survival protein myeloid cell leukemia 1 (Mcl-1) is an anti-apoptotic member of the Bcl-2 family of...
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First woman possibly cured of HIV by transplanting HIV-resistant stem cells from umbilical cord blood. @persaud_deborah @UCLA Read more in @CellCellPress
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Over the last 10 years, the #CRISPR toolbox and its applications have profoundly changed biological research, enabling advances through applications in plants, animals, and humans. A recent #ScienceReview highlights a decade of the technology: https://t.co/AptQ1SwlXW
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Lipinski’s Rule of 5 has been highly influential in guiding Med Chem in the past 25 years. What does it offer for the next 25 years of drug discovery? @HartungIngo and colleagues provide answers here:
nature.com
Nature Reviews Chemistry - Twenty five years ago, Christopher Lipinski and colleagues published arguably the most influential sentence in small-molecule drug discovery. Their cleverly crafted...
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Researchers have discovered the first known "virovore," an organism that feeds on viruses. Probably there are many others like it -- an entire, previously unknown food chain. One day into 2023, and already things are going topsy turvy. https://t.co/OvYfKM45Fm
#ecology #life
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Here's the slide that took me 6 months to make. The six classes of molecular interactions for drug design. Clearly H-bonds are the first thing to master as a drug designer followed by pi-pi and sigma-sigma interactions.
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This is in my eyes the most important annual paper for students preparing for a job interview in medicinal chemistry (or process chemistry): provides a great overview about representative drug structures, their targets & synthetic routes used. @ACSBioMed
https://t.co/DtjIBLEPXZ
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PERSPECTIVE in Journal of Medicinal Chemistry- Mechanistic Insights for Drug Repurposing and the Design of Hybrid Drugs for Alzheimer’s Disease https://t.co/jYiK9eGYeJ
@Drug Repurposing @Repurposing @drug development @Alzheimer's disease @demnetia @ACSPublications
pubs.acs.org
The heterogeneity and complex nature of Alzheimer’s disease (AD) is attributed to several genetic risk factors and molecular culprits. The slow pace and increasing failure rate of conventional drug...
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🔥 New advance article for RSC Chemical Biology! 🔥 Nathan W. Luedtke et al @mcgillu exploring [4 + 2] and [2 + 4] #cycloaddition reactions on single- and double-stranded DNA! #chembio #bioorthogonal 🧐Read the #OpenAccess article 👉 https://t.co/iz7YXHXvjy
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Latest article: Chitosan with pendant (E)-5-((4-acetylphenyl) diazenyl)-6-aminouracil groups as synergetic antimicrobial agents https://t.co/DVIv7hNHGd
@JMaterChem @RoySocChem @deepthiramesh92
pubs.rsc.org
Conventional antimicrobial agents are losing the war against drug resistance day-by-day. Chitosan biopolymer is one of the alternative materials that lends itself well to this application by fine-t...
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