David Perlmutter, MD
@DavidPerlmutter
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Neurology, Functional Medicine, Nutrition, Author, Lecturer
Naples, Florida, USA
Joined July 2009
There is no cure for Alzheimer’s. Prevention is essential. If we want a future with a lower risk of Alzheimer’s and cognitive decline, we must care for the brain long before symptoms begin. My new book Brain Defenders is a practical guide for doing exactly that. Pre-order now:
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Your genes are not your destiny. Epigenetics shows that food, sleep, stress, and environmental exposures influence how genes are expressed. One example: sulforaphane in broccoli sprouts, which activates antioxidant and detox pathways. Small choices can influence how your
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Barnes & Noble is offering 25% off on pre-orders for Brain Defenders to B&N Rewards members (and Premium Members get an additional 10% off)! Place your order at https://t.co/LY1WBvUGEZ between now and Thursday, March 26 and use code PREORDER25 at checkout.
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March is #NationalSleepMonth, which raises the question: How well are you sleeping? Sleep is when the brain repairs, detoxifies, and resets. Be honest… how has your sleep been lately?
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A recent meta-analysis published in Neurology offers encouraging news: women who closely follow a Mediterranean-style diet appear to have about a 12% lower risk of stroke. Read more on my blog:
drperlmutter.com
A recent meta-analysis published in Neurology offers encouraging news: women who closely follow a Mediterranean-style diet appear to have about a 12 percent lower risk of stroke. That finding is...
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What does the Nile River reveal about how far we’ve drifted from the biological principles that once protected human health? Realigning with them may be one of the most urgent challenges of our time. https://t.co/ELCzEry7wb
drperlmutter.com
I’m writing this blog while cruising south (upstream) on the Nile River, watching the shoreline drift by in its slow, ancient rhythm. It is impossible to be here and not …
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GLP-1 drugs like Ozempic may do more than support weight loss. Research on Exenatide suggests possible neuroprotective effects in Parkinson’s. I shared practical strategies to support mitochondrial health on @epochtimes’s @seevitalsigns: https://t.co/bLU0IYyUKD
theepochtimes.com
Protecting the brain may start with protecting its energy supply.
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Brain fog is often metabolic, not mental. If you are reaching for more caffeine, try: A 10 minute walk Water with electrolytes Protein or healthy fats Deep breathing
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If using a GLP-1, protect muscle with resistance training and adequate protein. Weight loss works best when strength is preserved.
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GLP-1 medications can support weight loss, but they don’t distinguish between fat and muscle. Muscle is essential for metabolism, insulin sensitivity, balance, and independence.
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What fuel strategy best supports long-term metabolic health, mitochondrial efficiency, and human performance? On the latest episode of The Empowering Neurologist, I speak with @AKoutnik to discuss why there are no true “erasers” when it comes to health and why the fundamentals
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The brain sees alcohol as a toxin every time. When alcohol enters the body, it triggers inflammation, oxidative stress, and disrupted signaling. This response doesn’t change by drink type or occasion. Understanding biology helps you make informed choices.
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Stop scrolling for a breath. Then continue a little more aware than you were 10 seconds ago.
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Berberine has earned a place in my daily supplement routine because the research shows it supports blood sugar regulation, lipid metabolism, and pathways tied to brain and metabolic health. I choose evidence-based tools that truly complement nutrition, movement, and sleep.
drperlmutter.com
When people ask me about supplements, I always come back to one foundational principle: if it doesn’t meaningfully improve metabolic health, it probably doesn’t belong in my routine. That’s exactly …
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Getting older doesn’t mean accepting less energy, less clarity, or less resilience. It means becoming more intentional about the daily choices that shape your brain and body.
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One small habit you repeat daily matters more than the occasional “perfect” week.
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