Carlos F Lopez
@ceelox4
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Systems biology, biochemistry, biophysics, modeling, simulation, high performance computing. What we need more of is science. Opinions are all mine.
Nashville, TN
Joined July 2016
Republican women: your vote is a secret. Your husband doesn’t have to know.
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Tackling network dynamics problem w/ hybrid ultradiscretization and Bayesian inference. Generalizable to any dynamic network! Signal execution modes emerge in biochemical reaction networks calibrated to experimental data: iScience
cell.com
Biochemistry; Biological sciences; Computational chemistry; Mathematical biosciences
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The final speaker of #Math4CancerBio is former @NCIsysbio PI now at @altos_labs, Carlos Lopez @ceelox4 presents some of his work on model inference.
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An interesting way to find important nodes in biochemical reaction networks... Thanks to Mustafa Ozen and @CancerSysBio
https://t.co/TGOMIVIgCD
nature.com
npj Systems Biology and Applications - Data-driven structural analysis of small cell lung cancer transcription factor network suggests potential subtype regulators and transition pathways
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Everything we know about fundamental physics may be summarized by the statement: "Nature doesn't care about coordinate systems." Indeed, rather remarkably, all of our most foundational theories of physics appear to have (essentially) no content *apart* from this statement. (1/9)
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A method to automatically explore mechanistic hypotheses from data using logic models, with @bryan_glazer #NIHfunded #NSFFunded
https://t.co/qtPUnK7Yl8
frontiersin.org
Many important processes in biology, such as signaling and gene regulation, can be described using logic models. These logic models are typically built to be...
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What if publishing houses (e.g. Elsevier, Springer, etc) paid authors a residual fee for each download / paper purchase just like authors in other fields? They are publications after all and someone is making money off them... just not the authors.
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Very proud of this work with MaFe Senosain and team! In honor of the late and great Pierre Massion. @VeraPancaldi Integrated Multi-omics Analysis of Early Lung Adenocarcinoma Links Tumor Biological Features with Predicted Indolence or Aggressiveness
aacrjournals.org
Lung adenocarcinoma (LUAD) is a heterogeneous group of tumors associated with different survival rates, even when detected at an early stage. Here, we aim to investigate the biological determinants...
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Did you know that I share my entire super-accessible, university #MachineLearning course online? Recorded lectures, with 100s of #Python code walk-throughs, interactive dashboards to explore concepts & models, and well-documented, best-practice demonstrations. Join me on
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It has always bugged me when people talk about "the model" for a biological process when there could be many hypotheses to formulate a mechanism. Here we employ Bayesian methods for multimodel inference and hypotheses exploration. PLZ RT!
journals.plos.org
Author summary Mechanisms of biological processes that explain and predict biological behaviors continue to be challenging to attain. In this context, logic-based models with few parameters can be...
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Introducing "data-to-paper": autonomous AI research! We've let it play with the large CDC Health Survey Dataset. Went to lunch. When back, it had already chosen several research topics, wrote data analysis codes, interpreted results and wrote 5 transparent, reproducible papers.
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The fact that there are multiple candidates for what this linear regression is blows my mind 🤯 (Original, of course: https://t.co/N87MPaNh3g)
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Scientific colour maps 8.0 https://t.co/ePG4rAY1tK
#useBatlow
#ScientificVisualisation #visualisation #Science #ColourPalette #DataVis #GraphicDesign
#OpenSource #Accessibility #Colour #AcademicCommunityContribution #ACC 1/n
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Every government & university science administrator should get a framed copy of these words of max perutz on the first day on the job.
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Super excited to share our new paper: "A dynamical low-rank approach to solve the chemical master equation for biological reaction networks", with Martina Prugger and Lukas Einkemmer. Using an old trick on a new dog (?). Check it out and RT, plz! https://t.co/zU0AyAxh2x
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Clinton got a weak economy from Bush & built a surplus Obama got a recession from W & built the longest job creation stretch in history Biden got a reckless budget from Trump & cut the deficit $1.4T in 2022 35 years proof that GOP destroys the economy & Dems build the economy
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Why are states loosening child labor laws? @roywoodjr hears from NYT journalist Hannah Dreier and @nfloresy of Justice for Migrant Women in the latest Beyond the Scenes
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Beef emits 31 times more CO₂ per calorie of food than tofu does. By cooking so many cows, we are cooking ourselves, too. Forgoing steaks may be one of the most efficient ways to reduce our carbon footprint
economist.com
Cattle are a surprisingly large producer of greenhouse gases
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