@organoidscience

Our first organoid study is in @EMBO reports! Controlling fluid dynamics produces organoids with uniform morphology and preserved transcriptional identity across batches and cell lines. Thanks to @G_Aiello91, Mohamed Nemir, @BarboraVidimova & @CelVivo3D! https://t.co/2YISmkRjBr

Check out our new work on organoids! Reducing fluid flow shear stress during neural induction, we obtained consistent morphology, cellular composition and metabolic profiles across batches and different cell lines. https://t.co/cIdAcWHz2Q @unil @DNF_neuro @BOrganoid

Today is International Fragile X Awareness Day, an opportunity to shed light on a genetic condition that significantly impacts individuals and families across the globe. Let's continue to spread knowledge, raise awareness, and work all towards a brighter future together.

We explored the impact of CYFIP1 gene variants on NDDs using flies and fibroblasts. Our research revealed disruptions in the wave regulatory complex, impacting processes such as actin polymerization and brain morphology. Published in @BiologicalPsyc1 🪰 https://t.co/gPNWJFyGDA

We are very happy to welcome Kyriaki to our lab! Kyriaki joins us to investigate mutations in ASD-linked genes using Drosophila melanogaster. Her expertise in genetics and molecular pathways makes her a great asset to take our research on #ASD a step further.🪰

Unique Opportunity at Claudia Bagni's Lab: Seeking a Passionate and Dedicated Laboratory Technician! 🌟 Join Our Team

Crafted from real-life experiences, 'Instants (x) Fragiles,' a poignant play by the Compagnie Essentiel Ephémère supported by the @FrenchFragileX association sheds light on the challenges of #FragileXSyndrome. Teaser here https://t.co/wQ9PYybhAU.

Exciting news! Our review on repurposing cancer drugs for #ASD treatment is out in @TrendsinPharma @CellPressNews . Discover new #TherapeuticStrategies in #neurodevelopment. Read for free   https://t.co/vxHA3BPi88 until 26/12/23. #Neuroscience #Innovation @DNF_neuro @FBM_UNIL .

Recently awarded CAVALIERE O.M.R.I. - Knight of the Order of Merit of the Italian Republic. Grateful to all my mentors, students and colleagues for contributing to my academic journey. Honored by President Mattarella for my work on #FragileXSyndrome and #Autism. Thank you all!

Very honored and grateful!! 🤩Merci à la @FBM_UNIL!! 🙏🏻 I couldn’t have achieved this without the support of my mentors and colleagues from @BagniLab, family and friends who have believed in me every step of the way! Felicitations à tous!! 🍾🎉

Two open postdoc positions at @BagniLab @DNF_neuro! We are seeking for motivated candidates to investigate the mechanisms underlying neurodevelopmental deficits using🪰and 🐭. #postdoc #neuroscience #DNF Send CV, Cover letter and 3 referees by August 1st, 2023 (see ad).

Interested in understanding what modulates striatal flexibility? Here is our paper in @NeuroCellPress on FXS! https://t.co/QDmYdy8hVR Congrats to @valemercaldo, all the coauthors and @BagniLab . @DNF_neuro @FBM_UNIL @unitorvergata @unil

Altered striatal actin dynamics drives behavioral inflexibility in a mouse model of fragile X syndrome - New article on @NeuroCellPres from the @BagniLab https://t.co/43W4NUleXv @FBM_UNIL @unil @unitorvergata @LndsNeuro @NeuroLeman

Agire sull'area cerebrale dello #striato per migliorare i #disturbi #comportamentali legati all’ autismo e alla sindrome dell'X fragile (FXS). Nuovi meccanismi molecolari e nuove speranze terapeutiche nello studio di @BagniLab su @NeuroCellPress @unil https://t.co/nIFVG4e5P1

Press release:

Finally, we demonstrated that modulation of SREBP or the Malic enzyme was sufficient to ameliorate sleep deficits in Cyfip heterozygous flies. The work suggests modulation of the SREBP metabolic axis as a new avenue worth exploring for its therapeutic potential in sleep disorders

3. Furthermore, we showed that the over-activity of SREBP and one of its targets, the Malic enzyme, cause sleep deficits in Cyfip mutant flies via dysregulation of the brain NADP+/NADPH ratio.

2. RNAseq data of Cyfip heterozygous flies revealed deficits in lipogenic and energy metabolism genes downstream the Sterol Regulatory Element Binding Protein (SREBP).

1. Using a fly model for the human CYFIP1 haploinsufficiency we identified a new mechanism modulating sleep behavior. Cyfip mutant flies have reduced sleep at night. In addition, NADP+/NADPH levels (regulating the wakefulness/sleep switch) are impaired at sleep onset.