Anuja Walimbe
@anuja_walimbe
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Integrated Ph.D student @SamratLabMohali @IiserMohali
Joined June 2020
Happy to share our community note published in Nature Communications. In this 14-page article (34 authors from 9 countries), we discuss current practices in biomolecular phase separation and hope it will be useful to the biomolecular condensate community. https://t.co/UgwnvPpOk2
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Fluorescence Lifetime-Based FRET Biosensors for Monitoring N Terminal Domain-Dependent Interactions of TDP-43 in Living Cells: A Novel Approach for ALS and FTD Drug Discovery | ACS Chemical Neuroscience
pubs.acs.org
Pathological aggregates of TDP-43 are implicated in Alzheimer’s disease, frontotemporal dementia, and amyotrophic lateral sclerosis. While therapeutic efforts have traditionally focused on mitigating...
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Happy to share our latest paper published in Science Advances @ScienceAdvances @AAAS. Congratulations to my incredible students, Sandeep @Sandeep61011718, Roopali @RoopsieK (joint-first author), Anusha @AnushaSarbahi & Ashish @AshishJ87810510 @IISERMohali. https://t.co/AVjuGxAVDM
science.org
A chaperone tasked with protein quality control tunes the phase behavior of tau and prevents its pathological phase transitions.
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Please Retweet! @MBU_IISc @iiscbangalore is organizing a 2-day national symposium (April 28-29) with "AI in biophysics" as its theme. You are cordially invited to attend this meeting!! Visit our (in progress) symposium portal for more details. https://t.co/nX3q6sFP9H
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TDP-43 seeding induces cytoplasmic aggregation heterogeneity and nuclear loss of function of TDP-43: Neuron
cell.com
Rummens et al. demonstrate that amyloid-like fibrils trigger TDP-43 aggregation and nuclear depletion, key hallmarks of neurodegenerative disorders. This provokes a unique transcriptomic signature...
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Happy to share our joint Indo-French @IFCPAR collaborative paper with Sonia Longhi @LonghiSonia & her colleagues published in Protein Science @ProteinSociety. It was great to be part of this work. Congratulations to @anuja_walimbe & @aroralisha20. https://t.co/xO2yI0tK7S
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Excited to share that my student Ashish Joshi @AshishJ87810510 has been selected for the Biophysical Society's Biological Fluorescence (BF) award (sponsored by PicoQuant) based on his PhD work @IISERMohali on which he'll speak at the BF Subgroup Symposium in Los Angeles on Feb 15
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Happy to share our latest paper published in the Journal of Molecular Biology. Congrats to @aroralisha20 (joint corresponding author), @Dipankar_11 (joint first author), @Snehasis_99 @AnushaSarbahi @Sandeep61011718 @DCS_IISERMOHALI @DBS_IISERM @IISERMohali
https://t.co/UTUn2EHfS5
What great news to wake up to—acceptance of our first 2025 paper—just accepted for publication in the Journal of Molecular Biology (our 4th JMB). Congratulations to @aroralisha20 (who will soon defend her PhD thesis) and other lab members. I'll post the paper once it's published.
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Deciphering the interactome of Ataxin-2 and TDP-43 in iPSC-derived neurons for potential ALS targets:
journals.plos.org
Ataxin-2 is a protein containing a polyQ extension and intermediate length of polyQ extensions increases the risk of Amyotrophic Lateral Sclerosis (ALS). Down-regulation of Ataxin-2 has been shown to...
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The role of specific phosphorylation patterns in the oligomerization of Tau-R4 https://t.co/gw2tS2bddU
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If you're attending the International Conference on Optics Within Life Sciences (OWLS) at the Indian Institute of Technology (IIT) Bombay, you can visit two posters from our lab: Poster # 15: Anuja Walimbe @anuja_walimbe (Nov 19) Poster # 66: Lisha Arora @aroralisha20 (Nov 20)
Looking forward to attending the International Conference on Optics Within Life Sciences (OWLS) at the Indian Institute of Technology Bombay @IITBombay (Nov 18-21). I'll speak on our work on studying biological condensates using single-molecule & homoFRET. https://t.co/wL99OQrwCa
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Want to be more involved with @BiophysicalSoc & support the Intrinsically Disordered Proteins community? Nominate yourself or a colleague who is willing to serve in that position if elected (deadline: Friday, Nov 15). See you in Los Angeles in Feb 2025! https://t.co/tIHoQ0wJV0
📢We are inviting nominations for the Biophysical Society's Intrinsically Disordered Proteins Subgroup (IDP Subgroup) officers @BPS_IDP @BiophysicalSoc. Nominate a colleague or yourself using the following link (deadline: November 15, 2024): https://t.co/tIHoQ0xhKy
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I arrived in Tokyo to reunite with my better half @SamratLabMohali after 1.5 months & excited to see our latest paper published in @JPhysChem in which we show protein aggregation/disaggregation by Hofmeister cations. Congrats, @Deepika_MBLab @TIETofficial. https://t.co/JasW2jFjxp
pubs.acs.org
Protein aggregation resulting in either ordered amyloids or amorphous aggregates is not only restricted to deadly human diseases but also associated with biotechnological challenges encountered in...
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Excited to share our recent work on the homoFRET imaging of phase-separated condensates of Fused in Sarcoma (FUS) formed in vitro and in situ. Grateful to the incredible team and collaborators! 😇😇
Happy to share our latest (4th) paper in Nature Communications @NatureComms on energy migration via homoFRET to study biomolecular condensates in vitro & in situ (in cells). Congratulations to peerless @AshishJ87810510 @anuja_walimbe, et al. @IISERMohali. https://t.co/uMrOozZu5C
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Ataxin-2 polyglutamine expansions aberrantly sequester TDP-43 ribonucleoprotein condensates disrupting mRNA transport and local translation in neurons: Developmental Cell
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The Martin lab an open postdoctoral position at the interface of #cytoskeleton and #condensate biology, in a fantastic research community @unige_en @Biologie_UNIGE @MoCel_Geneva @LifeSciencesPh1 If interested, do not hesitate to contact us: https://t.co/JaoepaaU0o Please RT!
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Happy to share our latest paper in @JPhysChem in the special issue celebrating 25 years of the Chemical Research Society of India @ChemResSocIndia. Congratulations to @aroralisha20 @Dipankar_11 @Harshita3110 @DCS_IISERMOHALI @DBS_IISERM @IISERMohali. https://t.co/R8FmHOIZEu
pubs.acs.org
Thioflavin T (ThT) is widely employed as a fluorogenic marker for amyloid formation. ThT fluorescence is utilized to detect amyloid fibrils as well as to follow aggregation kinetics. Here, we make a...
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Congratulations to Dr. Santosh Satbhai @santosh7bhai on being awarded the Scientific High Level Visiting Fellowship (SSHN) 2024 by the French Embassy in India. Best wishes to Dr. Satbhai for his upcoming visit to France!
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Out today in @MolecularCell Our review article highlights recent advances in ribonucleoprotein condensate biology, focusing on RNA-driven phase transitions. Efforts led by @gable_wadsworth and Sukanya Srinivasan. https://t.co/Gxys3YQJgl
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#Walk_in_interview for a #JRF position in our lab is on 8th Oct 2024. Please spread the word.
Walk-in interview for the post of JRF is scheduled on October 8, 2024 in @IiserMohali @DBS_IISERM @sbslab_IISERM Please visit following link for more details. https://t.co/tlQ5z3Aji3 Repost plz.
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