Mariela Cortés López
@alt_spliced
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Alternative splicing on alternative music. RNA, R, single cells and long reads. | Postdoc at @landau_lab (NYGC | WCM) Previously: PhD - @Koenig_lab (IMB Mainz)
New York City, NY
Joined February 2012
First postdoc paper is now alive! Single-cell multiomics meets full-length #RNA . Check our work exploring the role of #splicing alterations in MDS and clonal hematopoiesis.
Online Now! Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths #stemcells
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Today, postdoc leaders from across campus met to determine next steps for winning a fair contract. We voiced our support for countering @WeillCornell's arbitrary deadline with OUR OWN strike deadline to ensure they make real progress by the end of the month. Stay tuned!
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#OnlineFirst In the Spotlight: RNA Splicing as a Therapeutic Vulnerability in Therapy-Refractory #MultipleMyeloma
https://t.co/4SMH4MymQm A commentary to Therapy-Resistant Subpopulation in Myeloma https://t.co/ZhQvbNlcA6
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Interested in learning how to be a good speaker and give effective talks? Season 2 of the NYC Postdoc Night Science Club begins October 15th. Join us NYC Postdocs for a 2hr workshop and maybe also a drink at a bar! Free registration (usually ~100 come): https://t.co/8dNh2KGXl2
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Today hundreds of us came out to our Picket to Protect Science to show @WeillCornell that they must agree to a fair contract now!
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Hi, we've made a new R package for APA analysis of long read RNA-Seq data. Works best on Oxford Nanopore direct RNA-Seq data. We call it APALORD. https://t.co/Y0IhGgtc8o
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Delighted to have our preprint led by @lvchosen1 up: Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells https://t.co/nMP5Xd7aEY 🧵 below ...
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The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to disease? These and other questions we will tackle within the SMaHT Network, now described in @Nature
https://t.co/5c1mfZOrOR
nature.com
Nature - The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.
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Sharing this op-ed we co-authored with other international postdocs, highlighting the struggle of doing science under an increasingly hostile political climate, while also fighting for fairer working conditions.
“We moved across the world to do life-saving research. We deserve stability, not uncertainty. We will strike if necessary for protection and a fair contract” https://t.co/TWna5WcLQg
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Very excited to share our new paper out now in @MolecularCell. We show how U1 snRNP -a well-known splicing factor- regulates the activity of alternative promoters in human cells
cell.com
Kim et al. uncover a role for U1 snRNP in regulating internal promoter activity. Beyond its canonical role in splicing, U1 snRNP suppresses premature polyadenylation, enabling upstream transcription...
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[1/n]📢How is your spatial analysis *transcript*-omic if transcripts are only aggregated to gene counts? Introducing SPLISOSM, our new computational method for learning the isoform landscape and its regulation from spatial transcriptomics data https://t.co/eBwnwA8Twx
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"Single-molecule multimodal timing of in vivo mRNA synthesis" a collaboration with Rippei Hayashi's lab, work led by AJ Sethi @_AJSethi #RNA #premRNA #splicing #RNAprocessing #m6A #polyadenylation
biorxiv.org
mRNA synthesis requires extensive pre-mRNA maturation, the organisation of which remains unclear. Here, we directly sequence pre-mRNA without metabolic labelling or amplification to resolve transcr...
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🚨Today in @CellCellPress, we show that RNA splicing factor mutations in myeloid cancers generate splicing-derived public neoantigens targetable by #TCR tx. Amazing collaboration co-led by @AbdelWahablab, @bradleybio, and @KlebanoffLab. #Tcellpower
https://t.co/5fycZiLEWg
cell.com
Common oncogenic RNA splicing factor mutations in myeloid malignancies generate recurrent splicing-derived neoantigens, which can be selectively targeted using a T cell receptor-based approach.
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Strike Authorization Vote is open!!! One year and not fair contract!!! Enough is enough!!
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What happens when sequencing costs go ⏬ ? Imagination and new opportunities go ⏫ @landau_lab Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the @UltimaGenomics platform 🧵👇 Lets goooo!! https://t.co/ZMaJqUKNDK
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We are excited to share our new preprint on LeafCutter2! Our new method clusters, quantifies, and classifies splice junctions and intron clusters according to their molecular functionality (e.g., protein-coding or NMD-splicing). @yang_i_li
https://t.co/xBChgMbnEH
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What protects individuals from developing blood cancers? Thrilled to share my work in @bloodgenes lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇(1/n) https://t.co/PNaCHa4D4k
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99% voted to unionize. 1 year later — still no fair contract. We’ve had enough! Strike Authorization Vote starts Monday, April 14, 2025.
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our work on the molecular differences between transcription factor isoforms is out now in @MolecularCell! key point: 2/3rds of TF isos differ in important properties like DNA binding & transcriptional activity many are "negative regulators" that are misexpressed in cancer
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See our new paper on discovering extensive conservation of human introns across hundreds of other mammals, with Ilia Minkin
academic.oup.com
Abstract. Despite many improvements over the years, the annotation of the human genome remains imperfect. The use of evolutionarily conserved sequences pro
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