Ever wondered what signals drive the activation of primordial follicles into the growing pool of follicles? We use scRNAseq to ask this question in the mouse ovary, described in this preprint summarising my two years at @TheCrick 🎉🎉

NEW CNE PAPER! Investigating GABA Neuron–Specific Androgen Receptor Knockout in two Hyperandrogenic Models of PCOS @IreneSucquart @CuriousCoyle @valentinarp979 Melanie Prescott @dr_kellyg Kyoko Potapov @DPBegg @RG_EggLab @KirstyWalters7 @RECampbell_inNZ https://t.co/wPPaTxQHzm

Our February issue is online! Read about oocytes from stem cells (@RG_EggLab @_emilyrfrost), Ganoderma lucidum as a next-generation cell factory, precision fermentation for non-alcoholic beer (@s_kampranis) and more: https://t.co/bDZ4L81L24

Contraception is a blunt tool. It's high time that we explore its effects on fertility, as well as its interrelationship with biological sex. Tap below to watch @GunesTaylor dismantle how we regulate fertility in the modern world.

Congrats to @RG_EggLab and collaborators in Vietnam and Brussels for the success of CAPA-IVM. It’s incredible to be witnessing the translation of a career in biomed to outcomes for patients - what a day!! 🤩

Nevertheless, we are in a very exciting time in women’s health research! Here's the link to our article: https://t.co/JT94BOZsNE Huge thanks to @RG_EggLab for all your efforts @UNSWMedicine. Please reach out and let us know what you think 😊

There’s lots of open questions surrounding IVG. Even if IVG can be achieved, will it ever be safe? Assessment of mutational load, risk to future generations and the testing of eggs without generating a pregnancy are all factors considered in our Outstanding Questions.

We think that the growth of human follicles in vitro remains the biggest roadblock standing in the way of human IVG. If this hurdle can be toppled, evaluating the health and quality of IVG-derived oocytes will require a lot of time, effort and caution.

However, IVG consists of 8 steps, and only 4 of those steps (embryo transfer, IVF, IVM and pre-IVM) are currently used in the ART clinic. The remaining 4 steps need to be mastered in humans and coupled with existing procedures if IVG is to become a clinical reality.

Assisted reproductive technologies are fundamentally limited by the number and quality of eggs retrieved from the ovary. IVG promises a solution – making new eggs in a dish from stem cells without the need for ovaries.

One BIGGGGGG question (with a million different answers): How long until we can make human gametes entirely in a dish? Our new opinion article is out in @TrendsinBiotech, where we discuss why we think in vitro gametogenesis (IVG) in women will be incredibly challenging🧵.

Check out our new review in @NatRevUrol where we discuss the genes driving sex development and genes involved in many types of DSD. Huge thanks to Ale, Nayla and Vince for all their hard work putting this together! @Hudson_Research https://t.co/2qhM6wMYm4

The 13th Congress of the Pacific Society for Reproductive Medicine is coming up soon, March 2023, in #sydney . Great chance to learn from global experts speaking on a wide variety of Reproductive Medicine topics. Don't miss the focused workshops especially the IVM Workshop!

What a brilliant time at @ReproductionSRB, coming home feeling very inspired by all the repro research. Incredible researchers and even better people, I’m already looking forward to next year 🤩

✨📣preprint announcement! We used combinatorial transcriptomics to probe for signals driving primordial follicle activation in the mouse ovary 🐭have a read & let us know what you think! 🔥@_emilyrfrost - it has been a pleasure seeing this through with you #dreamteam

So thankful for the opportunity to work with @GunesTaylor @BadgeRobin @scientistjessie to get this out into the world, DM if you have any thoughts/questions 🥳

A new understanding, guided by single-cell sequencing, of the establishment and maintenance of the #OvarianReserve in mammals. https://t.co/xGS5e4tJaL @EmmaOolemma @eileenamcl @scientistjessie @_emilyrfrost @AlexEPeters @GunesTaylor @BadgeRobin @TheCrick @Uni_Newcastle

Huge thanks to @EmmaOolemma @AlexEPeters @GunesTaylor @eileenamcl @scientistjessie and Robin for all your contributions, such a great collaboration to be a part of 🤩

🎉 Curious how scRNAseq has improved our knowledge of ovarian follicle development? See below: our take of the exciting papers in this space

Excited to be joining my first #ESASRBANZBMS conference today! Such a great lineup of presenters and I can't wait to meet everyone 😃