Ali Altıntaş
@_AliAltintas_
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Assistant Professor @Metabolcenter, University of Copenhagen 🇩🇰 | #Bioinformatician | #Molecular #Biologist | Forged in 🇹🇷
Copenhagen
Joined May 2012
🗨️ Just published in @NatureBiotech: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper link and annotated walkthrough in the thread below (1/11)
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And finally, huge congrats, @bahti_yil! 👏 Thanks for the opportunity and for leading such an impressive piece of work. Proud to be part of this global effort with you! 🌍🧬
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🚨 New paper out in Cell Host & Microbe! We built the first global atlas of mouse microbiome diversity across 51 vivaria and 12 wild colonies 🌍🐭 https://t.co/onoPv2OZsd
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🔍 Want to explore the data yourself? Check out the interactive resources: 🔗 https://t.co/etkZvqPJbD 🔗
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🌍 Excited to be part of this global effort! 🦠 Microbial and metabolic diversity was mapped across 51 vivaria & 12 wild colonies, revealing striking functional convergence despite taxonomic divergence. 🔗 https://t.co/8E8iBShkMk
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🚨 Dealing with sparse, noisy single-cell DNA methylation data (scBS-seq)? Check out #scDMV. It uses a zero-one inflated beta mixture model to tackle the excess of 0s/1s and low coverage, boosting accuracy in identifying differentially methylated regions (DMRs).
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Genotype-phenotype data from over 450,000 individuals was analysed to discover 205 genomic loci where an allele associated with increased adiposity was associated with a lower cardiometabolic disease risk to an individual
nature.com
Nature Medicine - Genotype-phenotype data from over 450,000 individuals was analyzed to discover 205 genomic loci where an allele associated with increase adiposity was associated with a lower...
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On the art of great article titles: this one’s dedicated to all the Reviewer 2s out there. 🔗 https://t.co/M6sX6Pd1YZ
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What a fantastic event! So great catching up with so many amazing colleagues ✨
The Zierath/Krook/Wallberg lab celebrated our current & former fellows and students at Nobel Forum sept 1 with a fantastic symposium on insulin action & metabolism. Grateful for all the trainees who traveled far & near to be with us to focus on science, inclusion, and innovation!
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❓ And what if your species is not present in this database? What do you do then? ❓ Isn't it enough to decide on an arbitrary cutoff (e.g. TPM < 1) for expression? 👉 Actually, you can do better than that. How? #BgeeCall #R package: https://t.co/A0RUrPPmL2
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❓ How do you know if a gene is expressed or not in a certain tissue/organ? 👉 If you are interested in animals, #Bgee database is the first place to go. 52 species, several tissues/organs... https://t.co/N4EpziKllp
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Before running your statistical test, double-check that its assumptions hold. Violations can lead to misleading results. Here's a handy tool to help: 🔗 https://t.co/IKNuvjeugd ℹ️ https://t.co/OzCzhI3aN4
#rstats #shiny #r
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"A drunk man will find his way home, but a drunk bird may get lost forever." -Shizuo Kakutani
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🚨Our latest: HIF1α mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise ⏰💪 📄
pnas.org
The regulation of metabolism in peripheral tissues is intricately linked to circadian rhythms, with hypoxia-inducible factor-1α (HIF1α) implicated ...
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13/ To every bioinformatician out there pulling all-nighters before someone else’s talk— I see you. You’re the ghostwriter of figures. The silent co-author. You deserve a first authorship and a nap.
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"(...) This is present for the pairs (body_mass_mm, bill_depth_mm) and (bill_depth_mm, bill_length_mm)."
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From the vignette after I fixed the typos: "Pairs of numeric variables exhibit Simpson's paradox if the ungrouped correlation is negative and the grouped correlations are positive (or vice-versa). (...)"
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