Shuhua (Steve) Zheng
@zheng_shuhua
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DO, PhD. | Radiation Oncology Resident, PGY-5 #NorthwesternMed | A.I.| https://t.co/FEV1krQAJj | 100 Ways to Kill Cancer
Joined December 2019
RT all the way
🧬 Cribriform architecture changes the story in localized prostate cancer. 🔥 ProtecT 15-year biopsy re-review shows who really needs treatment vs surveillance. 🎯 n = 712 with available slides (13 % cribriform+) 💊 Arms: ▫️ Active monitoring ▫️ Radical prostatectomy ▫️
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💡In glioblastoma, restricted diffusion outside the enhancing tumor (IRD) often heralds future enhancement. 📰Prospective cohort n=52: IRD in 21%; 64% enhanced on follow-up at ~110 days; IRD linked to higher mortality risk (HR≈3.2). https://t.co/0q4bDwQQy0
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Great pleasure meeting the giant in the field, winner of the world famous #WindyCityAnchorAward. Paul L. Nguyen MD, MBA. #radonc
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Inhibiting XIAP / cIAP can make HNSCC chemoRT resistant. Those IAPs are easier to target, but maybe not the major IAPs that mediate the resistance. Will present the FIC #PROTAC anti-BIRC5 as RT sensitiver in #ASTRO2025 #radonc #Glioblastoma #Neurosurgery
ascopubs.org
PURPOSETrilynX was a randomized, double-blind, phase III study evaluating the addition of xevinapant (an inhibitor of apoptosis proteins inhibitor) or placebo to chemoradiotherapy (CRT) in patients...
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ADCs are not just “guided missiles” — new biology is reshaping how we view them 🌊 Continuous payload exposure in circulation sustains cytotoxic thresholds 🔀 Antigen level ≠ response: extracellular cleavage enables efficacy in “HER2-null” tumors 🛡️ Fc functions &
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https://t.co/PR50c3sYJn Interesting study. Any pharma sponsored drugs with objective response (82%) for bulky solid tumor will be a big news.
redjournal.org
Spatially fractionated radiation therapy, specifically grid radiation therapy (grid-RT), is a treatment option for bulky tumors (≥6 cm). However, its modern use for locally advanced or metastatic...
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Chemo or Not? RT Alone Holds Strong After Hysterectomy 🚨 @OncoAlert 🎯 316 pts, stage IB–IIA, randomized RT vs CRT (NRG/GOG-263) 📊 3y RFS: 88.5% (CRT) vs 85.4% (RT) → NS 📊 OS trend favoring CRT, but no significance ⚠️ Toxicity: 43% vs 15% (CRT ↑) ✅ RT alone highly
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This cohort study suggests that chromosomal alterations should be included in the WHO grading criteria for meningiomas, as they are associated with worse outcomes and can refine the current classification system. https://t.co/E2OURavMVY
@DrAMansouri @afgao
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Perspective by Kerstin N. Vokinger, MD, JD, PhD, Guanqiao Li, MD, and Olivier J. Wouters, PhD (@ojwouters): The Rise of Drug Innovation in China — Implications for Patient Access in the United States and Globally https://t.co/73rVI3DpRU
#GlobalHealth #HealthPolicy
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Metastasis-directed radiotherapy without systemic therapy for oligometastatic clear-cell renal-cell carcinoma https://t.co/mi7LOzQWZR This single-arm, phase 2 trial evaluated metastasis-directed therapy (MDT) without systemic treatment in patients with oligometastatic
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Amazing 👏
🔥 PCS-9: SBRT + ENZA Doubles Disease Control in Oligometastatic CRPC @OncoAlert @dr_cury 🎯 Objective • Evaluate whether adding SBRT to ADT + enzalutamide ⬆️ outcomes in oligometastatic CRPC (≤5 mets) 🏥 Methods • Ph 2, randomized, 13 Canadian centers. • 100 men with
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Os 3 vs 1.7 months. Sad 😔
⚡️New study: Proton vs Photon CSI for leptomeningeal disease (@MayoClinic, n=36) ▶️No difference in serious CSI-related cytopenias ▶️OS ~3.0 mo (proton) vs 1.7 mo (photon), NS ▶️Photon VMAT-based CSI → a viable alternative when protons aren’t available or can’t be started
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Academic medicine is 51 pages of "we regret to inform you" emails
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Memantine may negatively related to RT associated neurocog function preservation ...
@gerryhanna @Eric73363938 @finn_corinne @aislingbarryro @JolyneOHare @DrJNaidoo @FordePatrick @MP_MacManus @_ShankarSiva @HegiFiona Curious that memantine appeared to have a negative association with neurocog function...
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Thank you! @ConquerCancerFd @RSNA for the funding support of the project.
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This will be the first public dislosure of FIC CNS penetrent #PROTAC for #radonc sensitization of CNS cancers at #ASTRO2025. Thank you @ASTRO_org for the travel award and mentor @maciejlesniakmd for all the support & guidance. Also, this resident is open for 2026 job market 🙌
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Here is a video on management of 4 common lower GI radiotherapy toxicities: 1. Radiation dermatitis 2. Diarrhea 3. Acute RT proctitis 4. Late/chronic RT proctitis Hope it is helpful! Full video (16 min) & slides 🧵 thread below. 1/X
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ESTRON Randomized Trial fSRS vs WBRT Resected Brain Met · Excellent LC w/fSRS · ↑↑ LMD w/fSRS compared to WBRT · Better cognitive outcomes w/fSRS https://t.co/sF9EeFxaxe
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