Wickens Group
@WickensGroup
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Leveraging the unique properties of light and electricity 💡⚡️ in synthetic methodology at UW-Madison Student-run account; opinions are our own
Joined March 2020
Finally, the mystery is solved 🕵️ We now know why allylic functionalization of alkenes via thianthrenation is Z-selective! In collaboration with the Gutierrez group, we uncovered a rare example of stereoselective deprotonation. Now at JACS!
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RT @J_A_C_S: Elucidating the Mechanism of Electrooxidative Allene Dioxygenation: Dual Role of Tetramethylpiperidine N-Oxyl (TEMPO) | JACS @….
pubs.acs.org
The cumulated π system of a nonsymmetric allene contains three distinct unsaturated carbons that imbue it with unique reactivity toward radicals as compared to its alkene and alkyne counterparts....
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RT @J_A_C_S: Alkene Carboxy-Alkylation via CO2•– | Journal of the American Chemical Society @ZachWickens @WickensGroup @UWMadisonChem @UWMa….
pubs.acs.org
Herein, we introduce a new platform for alkene carboxy-alkylation. This reaction is designed around CO2•– addition to alkenes followed by radical polar crossover, which enables alkylation through...
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RT @ZachWickens: As part of our ongoing collaboration with @Charles_chem at Merck, we found a new way to promote alkene carboxy-alkylation….
pubs.acs.org
Herein, we introduce a new platform for alkene carboxy-alkylation. This reaction is designed around CO2•– addition to alkenes followed by radical polar crossover, which enables alkylation through...
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The #WickensPOM for April is the Hu group’s azo-free Mitsunobu reaction! Check out their clever use of paired electrolysis to overcome the pKa limitation of nucleophiles in Mitsunobu!
onlinelibrary.wiley.com
A sustainable electrochemical Mitsunobu-type reaction, featuring azo-free alcohol activation and broad substrate scope, is reported. This practical method allows facial enantiospecific coupling of...
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The #WickensPOM for March is the Liu group’s aminative Suzuki-Miyaura reaction involving a formal nitrene insertion. We’re excited to see how this inspires other transition metal chemistry and for future work from the Liu group!
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🥁🥁🥁Wickens Paper of the Year drop 🥁🥁🥁.we loved this work from the @SongLinLab showing tunable frustrated radical pairs for regioselective C–H functionalization!
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RT @angew_chem: Alkene Thianthrenation Unlocks Diverse Cation Synthons: Recent Progress and New Opportunities (Zachary K. Wickens and co-wo….
onlinelibrary.wiley.com
The transformation of alkenes into thianthrene-derived cationic electrophiles unlocks a suite of net oxidative alkene transformations that have been elusive using conventional strategies. These...
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Check out our group’s first review article-- a minireview describing how you can get to diverse cation synthons using alkene thianthrenation electrophiles! It’s been amazing to see the progress in this area!
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In the latest #WickensPOM, the @MacMillan_Lab developed an undirected alkene dialkylation strategy with perfect regioselectivity by controlling the reactivity of three transient radicals!
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RT @PharmToTablePod: It’s here! It’s here! Check out the latest episode of the pod featuring @Charles_chem, @MyriaMikhael and @ZachWickens….
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In the latest #WickensPOM, the McCusker group and @MacMillan_Lab show Marcus inverted excited state lifetimes and novel photoreactivity for cobalt complexes. We’re excited to see where this paper takes the field of photoredox catalysis in the future!
science.org
An unexpectedly long excited-state lifetime makes an Earth-abundant cobalt complex an effective photoredox catalyst.
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In the latest #WickensPOM, the @GilmourLab use chiral Al salen complexes with light as a novel mode for deracemization of cyclopropyl ketones. Excited to see what else these systems may accomplish in the future!
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Check out our latest work @J_A_C_S leveraging electrophotocatalysis to access ketyl radicals! We found polycyclic aromatic hydrocarbons are a uniquely competent class of catalysts, which enabled our group's first non-fragmentation based reduction strategy
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In the latest #WickensPOM, the @GouverneurGroup developed a direct activation of fluorspar CaF2 via ball milling to access a safe and stable nucleophilic fluorinating reagent that bypasses HF-derived reagents in the synthesis of fluorinated compounds
science.org
A versatile inorganic fluorinating reagent is prepared by mechanochemical activation of fluorspar with a phosphate salt.
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RT @BarhamLab: Great talks by @HwangGroup , @jjoolab , @kwangminshin , Asst. Prof. Jang & Profs. Hong, Cho & You. Even if I heard their tal….
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