Tim Aikin
@TheDynamicTim
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New Ventures @ForesiteLabs applying emerging technology to biotech and therapeutics. Former @NSFGRFP fellow studying signaling dynamics @RegotLab @JohnsHopkins
Baltimore, MD
Joined March 2015
RT @jeffruffolo: What does pushing the boundaries of model capacity and data scale do for generative protein language models? I’m super exc….
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RT @HansClevers: Astonishing breakthrough in #organoid engineering, as reported in @Nature by T Recaldin,M Harter,L Steinacher,B Gjeta, and….
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RT @ElliotHershberg: Protein design for . checks notes. growing semiconductors (!!). Biology is nanotechnology.
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RT @GreenLabJHMI: We’re excited to share our study in @CellCellPress on the role of the MAP3 kinase ZAK in UV-induced apoptosis led by @2pr….
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RT @CantleyLab: We are delighted to share our work, now available in .@Nature:. Our scoring system can be accessed….
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I remember the first time I heard about this effort from @RegotLab . Very excited to dive into this for two reasons - identification of orphan kinase substrates (new pathways) and development of new synbio tools for kinase signaling. Great work!.
We are delighted to share the #tyrosine @KinaseLibrary, now in @Nature: Tyrosine predictions and enrichment analysis are now available: #TheKinaseLibrary #KL #part2. 🧵. 1/9.
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RT @CantleyLab: We are delighted to share the #tyrosine @KinaseLibrary, now in @Nature: Tyrosine predictions and e….
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RT @RegotLab: Connor's paper is out in Science! Thanks to all the present and former lab members for making this possible. If you are inter….
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RT @ForesiteLabs: We joined forces with ARCH Venture Partners /.@rtnarch to incubate @xaira_thera, a biotech company using AI to re-enginee….
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LLMs have proven useful for increasing sequence diversity while maintaining properties and structure, such as binding of antibodies and peptides. Here @jeffruffolo and @ProfluentBio team demonstrate enzyme sequence diversification while maintaining editing functions. Nice work!.
One of the first projects we took on at @ProfluentBio was designing novel gene editing proteins with language models. This grew into an initiative called OpenCRISPR, and today I’m excited to share that work (including the sequences we designed)!.
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RT @h4rrymcnamara: new results! We describe an optogenetic method to 'paint' patterns of morphogen signals in zebrafish embryos to guide th….
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RT @Merlin_Lange: Capturing the axial elongation of a zebrafish embryo (back and forth) using our single objective LSM DaXi #FluorescenceFr….
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RT @Ali__Shariati__: In our new preprint, we show that CRISPR activation of of just two endogenous regulatory elements is sufficient to sel….
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RT @Eric_Betzig: 2/ #FluorescenceFriday #cellbiology #bioart.Dictyostelia start out as unicellular amoeba, but eventually many amoebae come….
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RT @RegotLab: @TheDynamicTim and @AdlerGuerrero work is out in Developmental Cell! You guys are amazing. If you are interested in how onco….
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Fascinating work, has been awesome to see this story develop. Congrats @ithinkichan and team!.
This also builds on our prior work identifying "corrupt" or tumor-reprogrammed NK cells that promote tumor growth (similar to how macrophages have functional polarity). We show patients with these corrupt NK cells have worse outcomes - suggesting their translational potential.
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RT @LabWaggoner: A comprehensive single-cell breast tumor atlas defines epithelial and immune heterogeneity and interactions predicting ant….
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RT @ElliotHershberg: It's really hard to build brand new discovery technologies *and* a world-class therapeutics pipeline at the same time.….
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RT @lhinderling: Stem cell colonies from @PertzL 🤝 interactive data visualisation in @napari_imaging. Segmentation, tracking, single cell s….
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RT @Eric_Betzig: Nuclei of wild type (Htt-25Q) and mutant (Htt-94Q) live mouse ES cells. The mutation associated with Huntington’s disease….
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