Elliot Roth || SF
@ThatMrE
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those who do not make history are doomed to retweet it. founder @biopunklab prev. @spirainc @deepsciventures First Venusian astronaut. bio/acc
San Francisco, CA
Joined April 2009
If there are 30,000 centimillionaires worldwide and the global prevalence of rare diseases is about 5%, that means there are about 1500 rare diseases with a viable single-customer business model. Why aren't all of these active R&D projects?
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Today's most interesting Bay Area listing. A 57 bedroom former Seminary in Cupertino listed for $1. Yup, 1... dollar.
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👏🏻👏🏻👏🏻 good changes from good leadership. Take drugs off the streets and help people.
This new law enforcement sobering center marks a fundamental change in San Francisco: If you do drugs on our streets, we will arrest you. And with this new resource, we will give you a real chance to enter recovery.
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$10m to get to FIH and work your ass off to get there 🫡
lots of discourse on here recently on how to get FIH clinical data in US cheaper, faster, and more competitively with China Chinese biotechs, on average across modalities, generate FIH data with ~ $10M USD in funding total (R&D work, clinical ops, mfg, and pt recruitment) but
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Another day, another shitty bit of gatekeeping of important biotech info from AI companies. Do better @OpenAI @anthropic
trying to understand the biosecurity limits of ChatGPT and ..... my account was deleted for those that work on dangerous pathogens for their job, I wonder if there's a way around this...? I'm glad they're taking biosecurity seriously but wonder what the nuance is in their
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Really great listen to anyone who's curious about how pharma operates
Dave Ricks has been at @EliLillyandCo for 20% of its 150-year history. He came to the pub, poured his own Guinness, and gave us a 2-hour state of the pharma union: drug prices, clinical trials, patent clocks, the rise of generics, Chinese peptides, compounding pharmacies, the US
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Fascinating conversation where the biggest risks come at phase III. In my mind that seems to be a business model failure as the risk profile should decrease as the timeline increases. We need to do pharma differently.
pharma mgmt teams are the most understudied "pricers of risk" in existence. unlike prop trading, your counterparty here is discrete scientific truth 36-48 months out and you can't downsize your swings mid flight incredible lessons from watching this happen. great episode:
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I'm a simple man. If I see a field trial of genetically-engineered trees, I read it. A recent preprint reports the largest field trial to-date of American Chestnut trees engineered to resist a blight. And the results look promising. For context: The U.S. was once filled with
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This is an excellent thread and important to note if you're thinking about jumping ship from the US
Breast cancer has made me spicy🌶️so buckle up buttercup I have thoughts today 💅 On #VeteransDay, we say “thank you for your service” Today, I want to ask an uncomfortable Q for #biotech: Who did you build your company for, and who are you leaving behind when it gets hard? 🧵
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Was ambushed at a party tonight with a guy who fundamentally didn't understand this concept and kept asking me the same question as I tried to escape: Q: "If AI is magic, will drug companies want it?" A: "No, something new needs to be tested in humans"
You have heard of AI slop in the context of short video creation. But the same principle applies when it comes to improving drug discovery: we absolutely do not need a deluge of new hypotheses; we need better predictive validity (as per @JackScannell13). https://t.co/kdEEQ38qbP
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This is such a good visualization of median home prices in Texas through to the west coast.
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Brilliant company, wonderful immigrant founder. Let's have more businesses like this in biotech!
🎙️ @BillionToOneInc Co-Founder and CEO Oguzhan Atay reflects on the molecular diagnostics company’s journey to becoming #NasdaqListed
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This is the potential of American manufacturing
How it started (2018): - Bought a laser - Developed instant quoting system - Hired 3 people - We can cut metal with lasers! - We can ship it to your door! How it went for 7 years (from what I can remember): - Bought another laser - Hired 9 more people - Added 23k lines of code
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The best answer for a new greenfield city is Cairo Illinois: it sits at the intersection of the Mississippi, Tennessee, and Ohio rivers and is practically uninhabited. The best answer for an existing city is probably…
Is there any place geographically you could see the United States building a new major city/metro?
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What do you do when you're overstimulated and your nervous system isn't regulating properly?
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Loved having a ton of @MinervaUni students drop by @BiopunkLab to paint with bacteria this past week!
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My unpopular opinion is that science advances one funeral at a time and sometimes the best thing to do is get out of the way of others.
James Watson, who won the Nobel for "discovering the structure of DNA," has died. He wasn’t a particularly deep or productive scientist. Rosalind Franklin did the hard technical work. Francis Crick had the real theoretical brilliance. Watson mostly got lucky by standing near
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Woah weird what accessible public transit can do to an economy
San Francisco being the second most dense city here is a crazy narrative violation
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