Josephine M. E. Tan
@TanJosephine_
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Postdoc @ University of Pennsylvania @LabSeale @PennIDOM | Lipids, Smooth Muscle, Food and Skincare
Philadelphia | Amsterdam
Joined January 2022
#PRDM16 identified as gatekeeper for #proatherogenic phenotype switching of #VascularSmoothMuscleCells (SMCs) with potential interest as #DrugTarget
https://t.co/84owfcPjm3
@PatrickSeale11 #SingleCell #AtheroscleroticPlaque #TranslationalScience
nature.com
Nature Cardiovascular Research - Tan et al. identify PRDM16 as a key repressor of fibrotic switching in smooth muscle cells and show that its downregulation in atherosclerosis drives smooth muscle...
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💡 Scientists including @TanJosephine_ at @LabSeale @Penn establish PRDM16 as a gatekeeper of smooth muscle cell fate and reveal its role in shaping atherosclerotic plaque composition. @NatureCVR | https://t.co/2esyQSQtSY
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De Nederlandse universiteiten hebben een gezamenlijk manifest gepubliceerd waarin ze het kabinet oproepen de bezuiniginen op universiteiten en wetenschap te stoppen.
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Excited to present my work on smooth muscle cell fate switching in atheroscleroris at #IVBM2024 !
Join us today at #IVBM2024 for an exciting session on #neuro-#immune modulation of #vascular function including speakers Daniela Carnevale, Ziad Mallat, Andrew Murphy, Josephine Tan & Bob Shih Liang-Lee 📌1pm CEST, Berlage Zaal 👉 https://t.co/uQtCJK9egs
#CardiovascularResearch
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For so many years, now we have a FACSable surface marker CD200 for 🐭(at least♂️) arterial #SmoothMuscleCells!😆🥳 #CITEseq Myh11-CreERT2:Rosa-ZsGreen:Ldlr-/-🐭 Are human SMCs also sortable?😌 @acbashore Muredach Reilly lab @CircAHA 2024 @RobertCBauer
https://t.co/3xVTO5tx9v
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Yes, our new paper by Aukie and @MiesvdStoel is now published at JCS! DLC1 provides negative feedback for YAP. https://t.co/2MpdDPiFMW
#mechanotransduction #angiogenesis #integrin #endothelial
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Our #HorizonEurope #MSCA network MIRACLE is recruiting 11 #PhD candidates in 7 partner labs to study the inflammatory regulation of cardiometabolic diseases. 🇳🇱🇫🇷🇩🇪🇫🇮🇨🇭🇮🇹 Apply now at https://t.co/viLXN4eetC Thanks for sharing this with your network!
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The Huveneers lab has a postdoc vacancy in Vascular Cell Biology !!! @amsterdamumc Apply here: https://t.co/FtKItai3Sk Please spread the word
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Excited that our most recent work was featured as the cover story in this recent @Dev_Cell issue! Congrats to @seoyoung_jun @AnthonyAngueira @EthanFein who spearheaded this work and special thanks to @TanJosephine_ for contributing her microscopy skills! https://t.co/YRhpiPhmvG
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We are hiring! We’re looking for a PhD student to work in collaboration within the TRR267 consortium across Germany, studying non-coding RNAs in vascular aging:
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Coming back from an inspiring #NAVBO2023, where I shared my work on SMCs in atherosclerosis. Very grateful for all the scientific exchanges and the two (?!) awards! See you next year! @vascularbiology
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Congratulations to my amazing lab mate and friend @seoyoung_jun @LabSeale on this beautiful paper recommended for everyone interested in #brownfat development. It was such a pleasure to work with you on this!
How does embryonic #brownfat develop? Very excited to share our recent findings in @Dev_Cell on GATA6, a crucial transcription factor required for Pparg expression and #brownfat development. Thanks so much to everyone involved! #adipocyte #obesity
https://t.co/uvnE25PG64
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Happy to share out latest review article on Vascular Mural Cells published in @Dev_journal ! https://t.co/hgmbRh7HfU
journals.biologists.com
Summary: This Review examines the signalling pathways controlling vascular mural cell biology during development and regeneration and analyses their role in proper vascular function in health and...
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I am absolutely delighted to share our peer-reviewed study now out in @ScienceMagazine that structurally definines how a biguanide related to #METFORMIN inhibits mitochondrial complex I! Thanks to the reviewers for their thoughtful suggestions :) https://t.co/uYcsV9uoBu
science.org
Biguanides inhibit complex I by binding in the quinone channel and exert a localized chaotropic effect.
🧵How do biguanides like #metformin inhibit mitochondrial complex I? In this new preprint, we use #cryoem and #enzymekinetics with a novel biguanide to answer this! @JNB_lab @injae_chung @MRC_MBU @mcgillu @Yin_zhan
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Looking for a fully funded PhD scholarship in cancer genetics & metabolism? Boy, do @owen_sansom & I have the thing for you! tl;dr mtDNA mutations are context-dependent drivers of cancer - but nobody knows how/why. Want to help find out? drop us a line 🙂
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The struggle is real #EqualPayDay. Ja, veel Nederlandse vrouwen werken parttime. Maar ook als fulltime werkende vrouw moet je vaak op je strepen staan. Hierbij een draadje van 4 ervaringen van vrouwen uit mijn omgeving die fulltime werken (en eentje ben ik zelf).
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It's official. I will be the next U.S. Senator from Pennsylvania. We bet on the people of Pennsylvania - and you didn’t let us down And I won’t let you down. Thank you.
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‘Allemaal een beetje armer’? Nee, niet allemaal. De economie groeit als kool, ook als je rekening houdt met inflatie. Waar blijft dat geld? Column, op veler verzoek een keer in pdf ;-). @DeGroene
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