Taeyoung Hwang
@TaeyoungHw
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Joined November 2017
Lewandowski, @Gabrijela_D, Watson, @TaeyoungHw, @hopihoekstra, @sauvagem1, @Noncodarnia and co examine the effects of the lncRNA Tug1. KO male mice are sterile. The locus has a cis-DNA repressor as well as encoding the RNA with trans effects, and an ORF https://t.co/iDWAC3q9V4
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Delighted to share our new preprint. TUG1 lncRNA and TERT mRNA are nuclear localized. Using single-cell RNA imaging, splicing analysis and ASOs we show that intron retention is the driving event for their nuclear localization. For more, check https://t.co/gs9vaBLPzL
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1/n We are excited to share our preprint: Polycomb-mediated Genome Architecture Enables Long-range Spreading of H3K27 methylation https://t.co/kdeZhGAA4n
#bioRxiv Fantastic collaboration with cool PhD students and postdocs from great research groups:
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Johns Hopkins files federal lawsuit in support of international students.
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Excited to share our recent work about PRC2-RNA interaction: RNA is necessary for proper PRC2 localization in human pluripotent stem cells. A collaboration with @YichengLong with full support from @Noncodarnia and Thomas Cech labs. https://t.co/cPORJmaJ0p
nature.com
Nature Genetics - Perturbation of RNA–PRC2 interaction in human pluripotent stem cells disrupts PRC2 chromatin occupancy and localization genome wide. PRC2–RNA interactions contribute...
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What a nice summary of our recent publication about PRC2-RNA interaction in @NatureGenet A fun collaboration with @YichengLong
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The work by Rinn and co-workers reveals that the Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis @Noncodarnia
https://t.co/ulslzPfzVt
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I just published "Constructing A Graph for Genome Comparison Swiftly" https://t.co/Wrv83kmbNP A bit more than a short tweet to explain how we can use graphs to compare genomes.
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In a new paper out this week in @GenomeBiology, researchers at LIBD show the human genome is most sensitive during the first five years of life, more than any other time in a person's life. These findings highlight the potential biological impact of early childhood adversity.
Work from @ajprice20, @fellgernon, @andrewejaffe and co, measuring DNA methylation in human cortical neurons over the first 23 years of life. Huge changes seen in first 5 years, Regions of dynamic methylation would not be seen in cortical homogenate. https://t.co/qFGdq3bZEN
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Excited to share our work @pnas! @ATStemCell @Noncodarnia @EvanHass108 TERT activation is heterogeneous among cancer cells and contrary to expectations, TERT mRNA is mostly retained in the nucleus. https://t.co/0LERqNKx4a
#RNA #cancer #telomeraseRNA
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Breaking the transcriptome barrier with seqFISH+(base20x3). Evolved from temporal barcoding with seqFISH(2014,base4), tissue(2016,base5), 2017-in vitro SPOTs & 2018-intron (base12). KeyPoints: in situ discovery tool,faster in imaging,neighbors-specific GE
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Interesting
I always wondered why should a lncRNA that’s translated to peptides be called a lncRNA. Now, it turns out there is a highly abundant mRNA that isn’t translated to protein and acts like a lncRNA! What should we call that? Very interesting work!
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Finally !! I remember how hard you worked for this quite a long time. Congratulations @ajprice20
Good news for people doing cell type-specific or single cell #RNAseq in human postmortem brain tissue (protocols typically are limited to nuclear RNA): At the gene level, the nuclear transcriptome is representative of the whole transcriptome https://t.co/0vhbvWN5OV 🧬🧠 (1/4)
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Proud to see our work @Noncodarnia @lewandoj @Gabrijela_D @taeyounghw and @hopihoekstra now out in BioRxiv! Tug1 locus essential for male fertility. Tug1 has RNA, DNA function and encodes peptide regulating mitochondrion.
biorxiv.org
Background Several long noncoding RNAs (lncRNAs) have been shown to function as central components of molecular machines that play fundamental roles in biology. While the number of annotated lncRNAs...
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